KETOPROFEN IN THE TREATMENT OF SORE THROAT - EFFICACY AND SAFETY OF A NONSTEROIDAL ANTI-INFLAMMATORY DRUG
Abstract
Sore throat is one of the most common symptoms reported during visits to the primary care physician. In most cases, its cause is a viral infection (90 to 95% of acute pharyngitis in adults and 70-85% in children), but there are also cases of other etiologies of infection or pain resulting from surgical procedures (including dental) or mechanical injuries.
In most cases, symptomatic treatment in the form of antiseptic, analgesic or anesthetic preparations is used to treat sore throat, regardless of the cause. Among the preparations available on the market, those containing ketoprofen have begun to gain popularity, which may prove to be an interesting alternative to the drugs currently used, both in the practice of a general practitioner and in hospital care.
The results of the study indicate that ketoprofen is highly effective in treating sore throats caused by both infections and surgical procedures, including dental procedures. Studies comparing ketoprofen with benzidamine have shown better efficacy of ketoprofen, longer duration of action and fewer side effects. The efficacy of ketoprofen in the pediatric population has also been proven for both the treatment of sore throats of infectious origin and those arising from surgical procedures.
Ketoprofen lysine salt is also effective in relieving pain occurring after tooth extractions, and has a good safety profile. Its efficacy is significantly higher than placebo and comparable to that of paracetamol, with no significant side effects. Thanks to its neutral pH, it also does not irritate the mucous membrane of the gastrointestinal tract.
The findings presented here suggest that ketoprofen may become an effective and safe alternative for the treatment of sore throat and localized oral pain in both outpatient and inpatient care. However, potential side effects should be monitored and further studies should be conducted to clearly assess the safety profile and efficacy of ketoprofen.
References
Spinks A., Glasziou P.P., Del Mar C.B. Antibiotics for treatment of sore throat in children and adults; Cochrane Database Syst. Rev. 2021; 12(12): CD000023
Hryniewicz W, Albrecht P, Radzikowski A. Rekomendacje postępowania w pozaszpitalnych zakażeniach układu oddechowego. Wydawnictwo finansowane ze środków Narodowego Programu Ochrony Antybiotyków na lata 2011-2015. Warszawa 2016.
Fal AM, Babicki M, Brożek-Mądry E, Dobrzyński P, Jaźwińska- Tarnawska E, Karniej P, et al. Guidelines/recommendations. Diagnostyka i leczenie wybranych infekcji oraz stanów zapalnych dróg oddechowych. Wytyczne dla lekarzy POZ. Lekarz POZ 2021;5(7);324-354.
Szenborn L., Sawiec P., Mrukowicz J. Ostre zapalenie gardła i migdałków (angina); Podręcznik Interna, https:/www.mp.pl (dostęp: 30.03.2025r)
De Paor M., Boland F., Fahey T., Smith S., MacDonncha E., Vellinga A., Management of sore throat (with focus on GAS) in young adults, Clinical Infection in Practice, Volume 23, 2024, 100368, ISSN 2590-1702, https://doi.org/10.1016/j.clinpr.2024.100368.
Gładysz A., Sawiec P. Choroba przeziębieniowa (przeziębienie), Podręcznik Interna, https:/www.mp.pl (dostęp: 30.03.2025r)
Ribolsi M., Marchetti L., Olmi L. M., Cicala M., Savarino M. Esophageal chest pain resembles heartburn in reflux metrics and response to proton pump inhibitor therapy; 01 November 2024 https://doi.org/10.1111/nmo.14953
Zhou Z., Gao L., Lv Z., Chen L., Lu K., Cai J., Sun J., Chen X., Prediction of Postoperative Sore Throat in Patients After Day-case Surgery With General Anesthesia: A Retrospective Study, Journal of PeriAnesthesia Nursing, Volume 40, Issue 1.
Desai B. K., A. Desai, L. Ganti, S. Elbadri, Primary Care for Emergency Physicians; Springer Nature, 23 Nov 2024,
Davis S., Soothing a sore throat, Published Online:1 May 2024 https://hdl.handle.net/10520/ejc-mp_sapa_v24_n2_a3
Schreiber M. L. Strep Throat: More than Just a Sore Throat; Medsurg Nursing; Pitman Vol. 33, Iss. 6, (Nov/Dec 2024): 302-304.
Shin-Yu L., Oral Candidosis: Pathophysiology and Best Practice for Diagnosis, Classification, and Successful Management; J. Fungi 2021, 7(7), 555; https://doi.org/10.3390/jof7070555
Krüger K, Töpfner N, Berner R, Windfuhr J, Oltrogge JH; Guideline group. Clinical Practice Guideline: Sore Throat. Dtsch Arztebl Int. 2021 Mar 19;118(11):188-94. doi: 10.3238/arztebl.m2021.0121. PMID: 33602392; PMCID: PMC8245861.
Citko A. Zastosowanie oktenidyny w praktyce lekarza rodzinnego. Lek w Polsce 2023;383(4):34–28 DOI: 10.57591/LEK.202304.05.
Alvarez-Marin R, Aires-de-Sousa M, Nordmann P, Kieffer N, Poirel L. Antimicrobial activity of octenidine against multidrug-resistant Gram-negative pathogens. Eur J Clin Microbiol Infect Dis; 2017;36(12):2379-2383. doi: 10.1007/s10096-017-3070-0. PMID: 28825186.
Bukhary S, Balto H. Antibacterial Efficacy of Octenisept, Alexidine, Chlorhexidine, and Sodium Hypochlorite against Enterococcus faecalis Biofilms. J Endod. 2017Apr;43(4):643-647. doi: 10.1016/j.joen.2016.09.013. Epub 2017 Feb 28. PMID: 28258812.
Zumtobel M, Assadian O, Leonhard M, Stadler M, Schneider B. The antimicrobial effect of Octenidine-dihydrochloride coated polymer tracheotomy tubes on Staphylococcus aureus and Pseudomonas aeruginosa colonisation. BMC Microbiol 2009;9:150. doi: 10.1186/1471-2180-9-150. PMID: 19630994; PMCID: PMC2726150.
Dąbrowska M, Zielińska-Bliźniewska H, Kwiatkowski P, Guenther, S, Łopusiewicz Ł, Kochan E, et al. Improved efficacy of eugenol and trans-anethole in combination with octenidine dihydrochloride against Candida albicans and Candida parapsilosis. Ann Agric Environ Med 2023;30(1):204-210. doi: 10.26444/aaem/157995. PMID: 36999876.
Küng E, Pietrzak J, Klaus C, Walochnik J. In vitro effect of octenidine dihydrochloride against Trichomonas vaginalis. Int J Antimicrob Agents 2016;47(3):232-4. doi: 10.1016/j.ijantimicag.2015.12.010. PMID: 26899578
Lorenz K, Jockel-Schneider Y, Petersen N, Stölzel P, Petzold M, Vogel U, et al. Impact of different concentrations of an octenidine dihydrochloride mouthwash on salivary bacterial counts: a randomized, placebo-controlled cross-over trial. Clin Oral Investig. 2018;22(8):2
Kuchar E. Zastosowanie oktenidyny, substancji skutecznej przeciw biofilmowi, w infekcjach gardła. Medical Tribune 2023;5;1-5.
Baza leków: ketoprofen; https:/www.mp.pl; (dostęp 30.03.2025r)
Gębka-Adamczyk N., Mizgała-Izworska E., Gębka D. Ketoprofen w bólu gardła; Świat medycyni i farmacji; lipiec 2024
Passàli D, Volonté M, Passàli GC, Damiani V, Bellussi L; MISTRAL Italian Study Group. Efficacy and safety of ketoprofen lysine salt mouthwash versus benzydamine hydrochloride mouthwash in acute pharyngeal inflammation: a randomized, single-blind study. Clin Ther. 2001 Sep;23(9):1508-18. doi: 10.1016/s0149-2918(01)80123-5. PMID: 11589263.
Marseglia GL, Veraldi D, Ciprandi G; Study Group on Respiratory Infections in Adolescents. Ketoprofen lysine salt treatment in adolescents with acute upper respiratory infections: a primary-care experience. Minerva Pediatr (Torino). 2023 Dec;75(6):890-895. doi: 10.23736/S2724-5276.23.07367-6. Epub 2023 Sep 15. PMID: 37712897.
Ruperto N, Carozzino L, Jamone R, Freschi F, Picollo G, Zera M, Della Casa Alberighi O, Salvatori E, Del Vecchio A, Dionisio P, Martini A. A randomized, double-blind, placebo-controlled trial of paracetamol and ketoprofren lysine salt for pain control in children with pharyngotonsillitis cared by family pediatricians. Ital J Pediatr. 2011 Sep 29;37:48. doi: 10.1186/1824-7288-37-48. PMID: 21958958; PMCID: PMC3192740.
Karpova EP, Tulupov DA, Fedotov FA. Ispol'zovanie nesteroidnykh protivovospalitel'nykh sredstv dlia kupirovaniia bolevogo sindroma posle tonzillotomii u deteĭ [The application of different non-steroidal anti-inflammatory drugs for the elimination of pain syndrome during the early postoperative period in the children following the surgical interventions on palatine tonsils]. Vestn Otorinolaringol. 2017;82(5):48-51. Russian. doi: 10.17116/otorino201782548-51. PMID: 29072664.
Durnovo EA, Shashurina SV, Bespalova NA, Khomutinnikova NE, Gliavina IA, Marochkina MS, Iartseva AV. [The clinical estimation of ketoprofen lysine salt effect on the intensitivity of acute pain syndrome in the oral cavity during surgical procedures and postoperative period]. Stomatologiia (Mosk). 2013;92(1):59-62. Russian. PMID: 23528405.
Balzanelli B, de Lorenzi C. Efficacia e tollerabilità di ketoprofene sale di lisina 80 mg granulato in bustine nel dolore post-traumatico in odontostomalogia: studio in doppio cieco vs placebo [Efficacy and tolerability 80 mg granulated ketoprofen lysine salt in posttraumatic orodental pain: double blind vs placebo study]. Minerva Stomatol. 1996 Jan-Feb;45(1-2):53-9. Italian. PMID: 8741094.
Fatti F, Ghirardini M, Martini A, de' Lorenzi C. Valutazione endoscopica gastrica dopo trattamento con ketoprofene sale di lisina 80 mg granulato in bustine per uso orale. Studio controllato vs placebo [Gastric endoscopic assessment after treatment with orally administered ketoprofen lysine salt (80 mg granular sachet). Controlled study vs placebo]. Minerva Med. 1994 Oct;85(10):531-5. Italian. PMID: 7800195.
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