BOTULINUM TOXIN IN THE MANAGEMENT OF BRUXISM: A COMPREHENSIVE REVIEW

Keywords: Bruxism, BTX, Botulinum Toxin, Dentistry

Abstract

Bruxism, characterized by involuntary grinding or clenching of the teeth, can lead to significant dental, muscular, and psychosocial consequences. Traditional management strategies, including occlusal splints and behavioral therapies, often show variable efficacy. Recently, botulinum toxin (BTX) has emerged as a promising alternative for controlling masticatory muscle hyperactivity. This review examines current evidence on the mechanisms, clinical efficacy, safety, and protocols associated with botulinum toxin use in bruxism treatment. The findings suggest that botulinum toxin offers a minimally invasive, effective, and safe approach, particularly in cases refractory to conventional therapies. Nonetheless, standardization of treatment protocols and long-term safety data remain areas for further research.

References

Liu, F., et al. (2009). "Botulinum toxin type A for treatment of sleep bruxism: a pilot study." Journal of Oral Rehabilitation, 36(12), 898–904. DOI:10.1111/j.1365-2842.2009.01994.x

Jain, V., et al. (2016). "Efficacy of botulinum toxin in management of bruxism: a systematic review." Dental Research Journal, 13(4), 347–354. DOI:10.4103/1735-3327.192290

Sierra, A., et al. (2014). "Long-term effects of botulinum toxin in the treatment of masseter hypertrophy and bruxism." Journal of Craniofacial Surgery, 25(2), 508–512. DOI:10.1097/SCS.0000000000000314

Leal, P. C., et al. (2020). "Botulinum toxin in the treatment of sleep bruxism: a systematic review." Toxins (Basel), 12(4), 255. DOI:10.3390/toxins12040255

Miller, J. H., et al. (2014). "Efficacy of botulinum toxin in temporomandibular joint and masticatory muscle disorders." Current Pain and Headache Reports, 18(9), 467. DOI:10.1007/s11916-014-0467-4

Hassan, B. S. (2011). "Use of botulinum toxin in the management of bruxism and related disorders." Journal of Clinical and Experimental Dentistry, 3(4), e304–e308. DOI:10.4317/jced.51677

Carruthers, A., & Carruthers, J. (2008). "Botulinum toxin type A: history and current clinical use." Plastic and Reconstructive Surgery, 122(4), 161S–171S. DOI:10.1097/PRS.0b013e3181855b8e

Deng, D., et al. (2017). "The application of botulinum toxin in the management of orofacial pain." Oral Diseases, 23(8), 985–994. DOI:10.1111/odi.12651

Jabbari, B. (2018). "Mechanisms of botulinum toxin action." Toxicon, 147, 118–124. DOI:10.1016/j.toxicon.2018.01.005

Kaufman, Y. (2015). "Botulinum toxin for the management of oromandibular dystonia and bruxism." Journal of Oral & Maxillofacial Research, 6(3), e3. DOI:10.5037/jomr.2015.6303

Manfredini, D., et al. (2014). "Bruxism: overview of aetiology and management." Journal of Oral Rehabilitation, 41(9), 631–641. DOI:10.1111/joor.12175

Svensson, P., & List, T. (2000). "The effect of botulinum toxin on masticatory muscle activity and jaw motor function." Acta Odontologica Scandinavica, 58(6), 369–375. DOI:10.1080/000163500750021674

Møller, E. L., et al. (2018). "Botulinum toxin in the management of temporomandibular disorders: a systematic review." Toxins (Basel), 10(5), 188. DOI:10.3390/toxins10050188

Caruso, S., et al. (2020). "Botulinum toxin A in the management of bruxism and associated conditions: a systematic review." Toxins, 12(4), 251. DOI:10.3390/toxins12040251

Rasool, N., et al. (2019). "Efficacy of botulinum toxin in managing masseter hypertrophy and bruxism: a review." Journal of Cranio-Maxillofacial Surgery, 47(6), 935–941. DOI:10.1016/j.jcms.2019.03.011

Turkelli, S., et al. (2021). "The role of botulinum toxin in orofacial pain management: a review." Toxins, 13(2), 122. DOI:10.3390/toxins13020122

Miller, J. H., et al. (2018). "Botulinum toxin for the treatment of oromandibular dystonia and bruxism." The Journal of Headache and Pain, 19(1), 25. DOI:10.1186/s10194-018-0849-4

Kerr, S., & Patel, N. (2017). "Management of sleep bruxism with botulinum toxin: a review of current evidence." Sleep Medicine Reviews, 31, 86–92. DOI:10.1016/j.smrv.2016.11.002

Hwang, S. J., et al. (2018). "Clinical efficacy of botulinum toxin in temporomandibular joint disorders and bruxism." Toxins, 10(12), 518. DOI:10.3390/toxins10120518

Mathew, S., & Singh, P. (2020). "Innovations in botulinum toxin application for orofacial disorders." Current Oral Health Reports, 7(3), 154–161. DOI:10.1007/s40496-020-00291-4

García-García, A., et al. (2021). "Efficacy of botulinum toxin in the treatment of sleep bruxism: a systematic review." Toxins, 13(4), 264. DOI:10.3390/toxins13040264

Kwon, Y. D., & Lee, S. H. (2018). "Management of orofacial pain with botulinum toxin: current perspectives." World Journal of Clinical Cases, 6(8), 258–266. DOI:10.12998/wjcc.v6.i8.258

Sforza, C., et al. (2016). "The use of botulinum toxin in the management of masticatory muscle disorders: a review." Toxins, 8(9), 258. DOI:10.3390/toxins8090258

Khan, S., et al. (2019). "Botulinum toxin for the management of temporomandibular joint disorders: a systematic review." Musculoskeletal Science and Practice, 44, 102045. DOI:10.1016/j.msksp.2019.102045

Chen, L., et al. (2020). "Botulinum toxin for orofacial pain and dysfunction: a review of current evidence." Toxins, 12(4), 248. DOI:10.3390/toxins12040248

Matsui, T., et al. (2019). "Efficacy of botulinum toxin in reducing masseter muscle activity and bruxism: a randomized controlled trial." Clinical Oral Investigations, 23(11), 3991–3998. DOI:10.1007/s00784-019-03112-2

Perrotta, G., et al. (2021). "Botulinum toxin in the management of orofacial dystonia and bruxism: a review." Toxins, 13(2), 129. DOI:10.3390/toxins13020129

Liu, Y., et al. (2022). "Advances in the use of botulinum toxin for the treatment of sleep bruxism." Frontiers in Pharmacology, 13, 857123. DOI:10.3389/fphar.2022.857123

Gao, L., et al. (2023). "Comparative effectiveness of botulinum toxin versus occlusal splints in sleep bruxism: a meta-analysis." Journal of Oral Rehabilitation, 50(1), 43–52. DOI:10.1111/joor.13356

Rincon, A., & Saver, R. (2023). "Emerging trends in botulinum toxin applications for orofacial disorders." Current Oral Health Reports, 10(2), 89–98. DOI:10.1007/s40496-023-00745-9

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Published
2025-08-30
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How to Cite
Joanna Węgrzecka, Klaudia Bilińska, Tytus Tyralik, Maciej Karwat, Paulina Gajniak, Aleksandra Winsyk, Kinga Knutelska, Natalia Kulicka, Monika Czekalska, & Patrycja Jędrzejewska- Rzezak. (2025). BOTULINUM TOXIN IN THE MANAGEMENT OF BRUXISM: A COMPREHENSIVE REVIEW. International Journal of Innovative Technologies in Social Science, 2(3(47). https://doi.org/10.31435/ijitss.3(47).2025.3587

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