THE IMPACT OF OBESITY ON CARDIOVASCULAR RISK. REVIEW OF THE LITERATURE

Keywords: Obesity, Cardiovascular Risk, Cardiovascular Diseases, Physical Activity, Cardiovascular Health

Abstract

Background: Obesity is a global health problem due to its increasing prevalence over the past several decades. It is strongly associated with an elevated risk of cardiovascular diseases, both directly through metabolic mechanisms affecting the circulatory system and indirectly through traditional risk factors such as hypertension, dyslipidemia, and type 2 diabetes.

Aim: This review discusses the pathological changes occurring in the cardiovascular system under the influence of obesity. It presents the mechanisms linking obesity with selected cardiovascular diseases and outlines the role of physical activity in obesity.

Methods: The review was conducted using the PubMed, Web of Science and Google Scholar databases, limited to full-text, open-access publications from the years 2013–2025.

Results: As body weight increases, the risk of cardiovascular diseases such as heart failure, hypertension, and arrhythmias also rises. Weight reduction helps lower the risk of developing these disorders. Combined aerobic and resistance training (CART), as well as High-Intensity Interval Training (HIIT), has a beneficial effect on well-being and the condition of the cardiovascular system.

Conclusion: Obesity and the metabolic disturbances it causes are strongly associated with an increased risk of cardiovascular diseases. Obesity is not only a co-existing factor but also an independent risk factor for cardiovascular conditions. Effective intervention requires an individual approach.

References

Powell-Wiley TM et al. (2021), Obesity and Cardiovascular Disease, Circulation, 143(21): e984–e1010, https://doi.org/10.1161/CIR.0000000000000973

Phelps Nowell H et al. (2024) Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults, The Lancet 403 (10431), 1027 - 1050, https://doi.org/10.1016/S0140-6736(23)02750-2

Welsh A., Hammad M., Piña I.L. & Kulinski J. (2024), Obesity and cardiovascular health, European Journal of Preventive Cardiology; 31(8), 1026–1035, https://doi.org/10.1093/eurjpc/zwae025

Csige I, Ujvárosy D, Szabó Z, Lőrincz I, Paragh G, Harangi M and Somodi S (2018), The Impact of Obesity on the Cardiovascular System, Journal of Diabetes Research, 2018 (1) Article ID 3407306, 12 pages, https://doi.org/10.1155/2018/3407306

Sahakyan KR, Somers VK, Rodriguez-Escudero JP, Hodge DO, Carter RE, Sochor O, Coutinho T, Jensen MD, Roger VL, Singh P, et al. (2015) Normal-weight central obesity: implications for total and cardiovascular mortality, Annals of Internal Medicine 163(11): 827–835, https://doi.org/10.7326/M14-2525

Piché ME, Poirier P, Lemieux I, Després JP (2018) Overview of epidemiology and contribution of obesity and body fat distribution to cardiovascular disease: an update, Progress in Cardiovascular Diseases 61(2):103–111, https://doi.org/10.1016/j.pcad.2018.06.004

Coutinho T, Goel K, de Sa DC, Carter RE, Hodge DO, Kragelund C, Kanaya AM, Zeller M, Park JS, Kober L, et al. (2013) Combining body mass index with measures of central obesity in the assessment of mortality in subjects with coronary disease: role of “normal weight central obesity”, Journal of the American College of Cardiology 61 (5):553–560, https://doi.org/10.1016/j.jacc.2012.10.035

Elagizi A, Kachur S, Carbone S, Lavie CJ, Blair SN (2020), A Review of Obesity, Physical Activity, and Cardiovascular Disease, Current Obesity Reports 9, 571–581, https://doi.org/10.1007/s13679-020-00403-z

Carbone S, Lavie CJ, Arena R (2017) Obesity and heart failure: focus on the obesity paradox, Mayo Clinic Proceedings 92(2): 266–279, https://doi.org/10.1016/j.mayocp.2016.11.001

Oikonomou EK, Antoniades C. (2019) The role of adipose tissue in cardiovascular health and disease, Nature Reviews Cardiology 16(2): 83–99, https://doi.org/10.1038/s41569-018-0097-6.

Araiza-Garaygordobil D, García-Villarejo M, González-Arias M (2024), Obesity and cardiovascular risk: a primer for the clinician, Archivos de Cardiología de México, 95(1):69-80, https://doi.org/10.24875/acm.24000123

Landecho MF, Tuero C, Valentí V, Bilbao I, de la Higuera M, Frühbeck G. (2019) Relevance of leptin and other adipokines in obesity associated cardiovascular risk. Nutrients 11(11): 2664, https://doi.org/10.3390/nu11112664

Khanna D, Welch BS, Rehman A. (2022) Pathophysiology of obesity, StatPearls [Internet], https://www.ncbi.nlm.nih.gov/books/ NBK572076

Gallo G, Desideri G and Savoia C (2024) Update on Obesity and Cardiovascular Risk: From Pathophysiology to Clinical Management, Nutrients 16(16), 2781, https://doi.org/10.3390/nu16162781

Lavie CJ, McAuley PA, Church TS, Milani RV, Blair SN (2014) Obesity and cardiovascular diseases: implications regarding fitness, fatness and severity in the obesity paradox, The Journal of the American College of Cardiology 63(14):1345–1354, https://doi.org/10.1016/j.jacc.2014.01.022

Alpert MA., Omran J and Bostick BP (2016) Effects of Obesity on Cardiovascular Hemodynamics, Cardiac Morphology and Ventricular Function, Current Obesity Reports 5, 424–434, https://doi.org/10.1007/s13679-016-0235-6

Zhou Z, Macpherson J, Gray SR, Gill JMR, Welsh P, Celis-Morales C,et al. (2021) Are people with metabolically healthy obesity really healthy? Aprospective cohort study of 381,363 UK Biobank participants, Diabetologia, 64(9):1963-1972 https://doi.org/10.1007/s00125-021-05484-6

Oguntade AS, Islam N, Malouf R, Taylor H, Jin D, Lewington S, Lacey B (2023) Body Composition and Risk of Incident Heart Failure in 1 Million Adults: A Systematic Review and Dose–Response Meta‐Analysis of Prospective Cohort Studies, Journal of the American Heart Association 12(13):e029062, https://doi.org/10.1161/JAHA.122.029062

Wang X, Dong J, Du Z, Jiang J et al. (2022) Risk of Heart Failure between Different Metabolic States of Health and Weight: A Meta-Analysis of Cohort Studies, Nutrients, 14(24), 5223, https://doi.org/10.3390/nu14245223

Jones NR, Taylor KS, Taylor CJ, Aveyard P (2019) Weight change and the risk of incident atrial fibrillation: a systematic review and meta-analysis, Heart 105 (23) 1799–1805, https://doi.org/10.1136/heartjnl-2019-314931

Aune D, Sen A, Schlesinger S. et al. (2017) Body mass index, abdominal fatness, fat mass and the risk of atrial fibrillation: a systematic review and dose–response meta-analysis of prospective studies, European Journal of Epidemiology 32, 181–192, https://doi.org/10.1007/s10654-017-0232-4

Berkovitch A, Kivity S, Klempfner R, Segev S, Milwidsky A, Erez A, et al. (2016) Bodymass index and the risk of new-onset atrial fibrillation in middle-aged adults. American Heart Journal, 173: 41–48, https://doi.org/10.1016/j.ahj.2015.11.016

Zheng Y, Xie Z, Li J. et al. (2021) Meta-analysis of metabolic syndrome and its individual components with risk of atrial fibrillation in different populations, BMC Cardiovascular Disorders 21 (90), https://doi.org/10.1186/s12872-021-01858-1

Hall JE, Do Carmo JM, Da Silva AA, Wang Z, Hall ME (2015) Obesity induced hypertension: interaction of neurohumoral and renal mechanisms, Circulation Research 116 (6): 991–1006, https://doi.org/10.1161/CIRCRESAHA.116.305697

Cunha CLP (2023) Obesity-Induced Hypertension, Arquivos Brasileiros de Cardiologia, 120(7): e20230391, https://doi.org/10.36660/abc.20230391

Ozemek C, Laddu DR, Lavie CJ, Claeys H, Kaminsky LA, Ross R, et al. (2018) An update on the role of cardiorespiratory fitness, structured exercise and lifestyle physical activity in preventing cardiovascular disease and health risk, Progress in Cardiovascular Diseases 61(5-6): 484–490, https://doi.org/10.1016/j.pcad.2018.11.005

Yumuk V, Tsigos C, Fried M, Schindler K, Busetto L, Micic D, Toplak H. (2015) European Guidelines for obesity management in adults. Obesity Facts 8 (6): 402–424, https://doi.org/10.1159/000442721

Lee DC, Brellenthin AG, Lanningham-Foster LM, Kohut ML, Li Y. (2024) Aerobic, resistance, or combined exercise training and cardiovascular risk profile in overweight or obese adults: the CardioRACE trial. European Heart Journal 45 (13), 1127–1142, https://doi.org/10.1093/eurheartj/ehad827

Al-Mhanna SB, Batrakoulis A, Wan Ghazali WS, Mohamed M, Aldayel A, Alhussain MH, Afolabi HA, Wada Y, Gülü M, Elkholi S, Abubakar BD, Rojas-Valverde D. (2024) Effects of combined aerobic and resistance training on glycemic control, blood pressure, inflammation, cardiorespiratory fitness and quality of life in patients with type 2 diabetes and overweight/obesity: a systematic review and meta-analysis, PeerJ 12: e17525, https://doi.org/10.7717/peerj.17525

Al-Mhanna SB, Mohamed M, Mohd Noor N, Aldhahi MI, Afolabi HA, Mutalub YB, Irekeola AA, Bello KE, Wan Ghazali WS. (2022) Effects of Circuit Training on Patients with Knee Osteoarthritis: A Systematic Review and Meta-Analysis, Healthcare (Basel) 10 (10): 2041, https://doi.org/10.3390/healthcare10102041

Chen T, Lin J, Lin Y, Xu L, Lu D, Li F, et al. (2021) Effects of aerobic exercise and resistance exercise on physical indexes and cardiovascular risk factors in obese and overweight school-age children: A systematic review and meta-analysis, PLoS ONE 16(9): e0257150, https://doi.org/10.1371/journal.pone.0257150

Ahmad AM, Mahmoud AM, Serry ZH, Mohamed MM, Abd Elghaffar HA (2023) Effects of low-versus high-volume high-intensity interval training on glycemic control and quality of life in obese women with type 2 diabetes. A randomized controlled trial. Journal of Exercise Science & Fitness 21(4):395–404, https://doi.org/10.1016/j.jesf.2023.08.003

Wilner B, Garg S, Ayers CR, Maroules CD, McColl R, Matulevicius SA, de Lemos JA, Drazner MH, Peshock R, Neeland IJ (2017) Dynamic Relation of Changes in Weight and Indices of Fat Distribution With Cardiac Structure and Function: The Dallas Heart Study, Journal of the American Heart Association 6 (7): e005897, https://doi.org/10.1161/JAHA.117.00589

Alpert MA, Lavie CJ, Agrawal H, Aggarwal KB, Kumar SA (2014) Obesity and heart failure: Epidemiology, pathophysiology,clinical manifestations, and management. Translational Research 164 (4), 345–356, https://doi.org/10.1016/j.trsl.2014.04.010

You T, Arsenis NC, Disanzo BL, Lamonte MJ. (2013) Effects of exercise training on chronic inflammation in obesity: current evidence and potential mechanisms, Sports Medicine 43: 243–256, https://doi.org/10.1007/s40279-013-0023-3

Views:

47

Downloads:

1

Published
2026-01-28
Citations
How to Cite
Ewa Wieczorkiewicz, Anastasiia Holoborodko, Eliza Garbacz, Patrycja Stępińska, Agnieszka Pocheć, Bartosz Lautenbach, Dariusz Nędza, Klaudia Wojciech, Anhelina Loputs, & Wiktoria Błaszczyk. (2026). THE IMPACT OF OBESITY ON CARDIOVASCULAR RISK. REVIEW OF THE LITERATURE. International Journal of Innovative Technologies in Social Science, (1(49). https://doi.org/10.31435/ijitss.1(49).2026.4626

Most read articles by the same author(s)