LIFESTYLE AND AUTOIMMUNITY: HOW MODERN HABITS SHAPE IMMUNE DYSREGULATION
Abstract
According to current estimates, between 80 and 150 autoimmune diseases have been identified. In the United States alone, over 50 million individuals live with an autoimmune condition. These disorders substantially impact healthcare expenditures and, most importantly, the quality of life, mental health, and physical functioning of affected patients. Epidemiological data indicate a steady increase in both the incidence and recognition of autoimmune diseases. Modern lifestyle factors exert a profound influence on immune system function and may contribute to their development. This review discusses key everyday habits—such as stress, physical activity, the use of substances (alcohol consumption, smoking), contemporary dietary patterns, the growing epidemic of obesity, sleep, as well as infections with pathogens such as SARS-CoV-2—that modulate immune responses and promote their dysregulation. This article is a comprehensive review based on studies retrieved from scientific databases such as PubMed and Google Scholar, with sources selected for their relevance and significance to the topic. The analysis indicates that chronic stress, sleep deprivation, substance use, and highly processed diets exacerbate inflammatory processes, immunosenescence, and inflammaging, thereby increasing susceptibility to autoimmunity. Conversely, health-promoting non-pharmacological interventions—including lifestyle modification, stress-regulation techniques, and regular physical activity—may alleviate immunological disturbances and improve patients’ functioning and quality of life. In light of current evidence, an integrated approach that combines medical treatment with lifestyle interventions represents a key component of both the prevention and management of autoimmune disorders.
References
Parnes, O. (2006). Autoimmune disease. Lancet, 367(9508), 389. https://doi.org/10.1016/S0140-6736(06)68125-7
Sharif, K., Watad, A., Bragazzi, N. L., Lichtbroun, M., Amital, H., & Shoenfeld, Y. (2018). Physical activity and autoimmune diseases: Get moving and manage the disease. Autoimmunity Reviews, 17(1), 53–72. https://doi.org/10.1016/j.autrev.2017.11.010
(N.d.-a). Nih.gov. Retrieved from https://www.niaid.nih.gov/diseases-conditions/autoimmune-diseases
Shapira, Y., Agmon-Levin, N., & Shoenfeld, Y. (2010). Defining and analyzing geoepidemiology and human autoimmunity. Journal of Autoimmunity, 34(3), J168-77. https://doi.org/10.1016/j.jaut.2009.11.018
Cooper, G. S., Bynum, M. L. K., & Somers, E. C. (2009). Recent insights in the epidemiology of autoimmune diseases: improved prevalence estimates and understanding of clustering of diseases. Journal of Autoimmunity, 33(3–4), 197–207. https://doi.org/10.1016/j.jaut.2009.09.008
(N.d.-c). Thelancet.com. Retrieved from https://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2805%2962867-X/fulltext
Tolentino Júnior, D. S., de Oliveira, C. M., & de Assis, E. M. (2019). Population-based study of 24 autoimmune diseases carried out in a Brazilian microregion. Journal of Epidemiology and Global Health, 9(4), 243–251. https://doi.org/10.2991/jegh.k.190920.001
Wang, L., Wang, F.-S., & Gershwin, M. E. (2015). Human autoimmune diseases: a comprehensive update. Journal of Internal Medicine, 278(4), 369–395. https://doi.org/10.1111/joim.12395
Zheng, J.-F., Lee, Y.-H., & Leong, P.-Y. (2024). The modern epidemic of autoimmunity. International Journal of Rheumatic Diseases, 27(11), e15426. https://doi.org/10.1111/1756-185X.15426
Over a billion people living with mental health conditions – services require urgent scale-up. (n.d.). Who.int. Retrieved November 21, 2025, from https://www.who.int/news/item/02-09-2025-over-a-billion-people-living-with-mental-health-conditions-services-require-urgent-scale-up
Xiao, N., Yang, X.-A., Zhang, F., Yu, Y.-G., Yi, X.-L., & Li, D.-R. (2025). Klotho levels in chronic overwork stress: An animal model study. Work (Reading, Mass.), 10519815251346465, 10519815251346465. https://doi.org/10.1177/10519815251346465
Stojanovich, L., & Marisavljevich, D. (2008). Stress as a trigger of autoimmune disease. Autoimmunity Reviews, 7(3), 209–213. https://doi.org/10.1016/j.autrev.2007.11.007
Song, H., Fang, F., Tomasson, G., Arnberg, F. K., Mataix-Cols, D., Fernández de la Cruz, L., Almqvist, C., Fall, K., & Valdimarsdóttir, U. A. (2018). Association of stress-related disorders with subsequent autoimmune disease. JAMA: The Journal of the American Medical Association, 319(23), 2388–2400. https://doi.org/10.1001/jama.2018.7028
Hames, A., Matcham, F., Makin, I., Day, J., Joshi, D., & Samyn, M. (2021). Adherence, mental health and illness perceptions in autoimmune liver disease: Looking beyond liver function tests: Looking beyond liver function tests. Journal of Pediatric Gastroenterology and Nutrition, 73(3), 376–384. https://doi.org/10.1097/MPG.0000000000003119
Hypothalamic-pituitary-adrenal (HPA) axis. (2024, April 15). Cleveland Clinic. https://my.clevelandclinic.org/health/body/hypothalamic-pituitary-adrenal-hpa-axis
Montero-López, E., Peralta-Ramírez, M. I., Ortego-Centeno, N., Sabio, J. M., Callejas-Rubio, J. L., Navarrete-Navarrete, N., García-Ríos, M. C., & Santos-Ruiz, A. (2024). Does stress response axis activation differ between patients with autoimmune disease and healthy people? Stress and Health: Journal of the International Society for the Investigation of Stress, 40(4), e3392. https://doi.org/10.1002/smi.3392
Sharif, K., Watad, A., Bragazzi, N. L., Lichtbroun, M., Amital, H., & Shoenfeld, Y. (2018). Physical activity and autoimmune diseases: Get moving and manage the disease. Autoimmunity Reviews, 17(1), 53–72. https://doi.org/10.1016/j.autrev.2017.11.010
Weyh, C., Krüger, K., & Strasser, B. (2020). Physical activity and diet shape the immune system during aging. Nutrients, 12(3), 622. https://doi.org/10.3390/nu12030622
Luo, B., Xiang, D., Ji, X., Chen, X., Li, R., Zhang, S., Meng, Y., Nieman, D. C., & Chen, P. (2024). The anti-inflammatory effects of exercise on autoimmune diseases: A 20-year systematic review. Journal of Sport and Health Science, 13(3), 353–367. https://doi.org/10.1016/j.jshs.2024.02.002
Metsios, G. S., & Kitas, G. D. (2018). Physical activity, exercise and rheumatoid arthritis: Effectiveness, mechanisms and implementation. Best Practice & Research. Clinical Rheumatology, 32(5), 669–682. https://doi.org/10.1016/j.berh.2019.03.013
Nagy, S., Tague, K., Ossorio, A., Patel, N., Callahan, R., Jose, E., Tran, M., Mejia, A., Centrella, M., McPhail, M. N., Junco, J., & Kesselman, M. M. (2025). The effects of yoga on the mental health of individuals with autoimmune disorders: A scoping review. Cureus, 17(1), e77669. https://doi.org/10.7759/cureus.77669
Shoenfeld, Y., & Tincani, A. (2005). Autoantibodies-the smoke and the fire. Autoimmunity, 38(1), 1–2. https://doi.org/10.1080/14756360400021882
Arnson, Y., Shoenfeld, Y., & Amital, H. (2010). Effects of tobacco smoke on immunity, inflammation and autoimmunity. Journal of Autoimmunity, 34(3), J258-65. https://doi.org/10.1016/j.jaut.2009.12.003
Nyhäll-Wåhlin, B.-M., Jacobsson, L. T. H., Petersson, I. F., Turesson, C., & BARFOT study group. (2006). Smoking is a strong risk factor for rheumatoid nodules in early rheumatoid arthritis. Annals of the Rheumatic Diseases, 65(5), 601–606. https://doi.org/10.1136/ard.2005.039172
Vessey, M. P., Villard-Mackintosh, L., & Yeates, D. (1987). Oral contraceptives, cigarette smoking and other factors in relation to arthritis. Contraception, 35(5), 457–464. https://doi.org/10.1016/0010-7824(87)90082-5
Chujo, S., Okamoto, S., Sunahara, R., Adachi, M., Yamada, K., Hayashi, H., Takii, T., Hayakawa, K., & Onozaki, K. (2010). Cigarette smoke condensate extracts augment collagen-induced arthritis in mice. International Immunopharmacology, 10(10), 1194–1199. https://doi.org/10.1016/j.intimp.2010.06.026
Lee, D. M., Phillips, R., Hagan, E. M., Chibnik, L. B., Costenbader, K. H., & Schur, P. H. (2009). Quantifying anti-cyclic citrullinated peptide titres: clinical utility and association with tobacco exposure in patients with rheumatoid arthritis. Annals of the Rheumatic Diseases, 68(2), 201–208. https://doi.org/10.1136/ard.2007.084509
Verpoort, K. N., Papendrecht-van der Voort, E. A. M., van der Helm-van Mil, A. H. M., Jol-van der Zijde, C. M., van Tol, M. J. D., Drijfhout, J. W., Breedveld, F. C., de Vries, R. R. P., Huizinga, T. W. J., & Toes, R. E. M. (2007). Association of smoking with the constitution of the anti-cyclic citrullinated peptide response in the absence of HLA-DRB1 shared epitope alleles. Arthritis and Rheumatism, 56(9), 2913–2918. https://doi.org/10.1002/art.22845
Sugiyama, D., Nishimura, K., Tamaki, K., Tsuji, G., Nakazawa, T., Morinobu, A., & Kumagai, S. (2010). Impact of smoking as a risk factor for developing rheumatoid arthritis: a meta-analysis of observational studies. Annals of the Rheumatic Diseases, 69(1), 70–81. https://doi.org/10.1136/ard.2008.096487
Hernán, M. A., Olek, M. J., & Ascherio, A. (2001). Cigarette smoking and incidence of multiple sclerosis. American Journal of Epidemiology, 154(1), 69–74. https://doi.org/10.1093/aje/154.1.69
O’Gorman, C., Bukhari, W., Todd, A., Freeman, S., & Broadley, S. A. (2014). Smoking increases the risk of multiple sclerosis in Queensland, Australia. Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia, 21(10), 1730–1733. https://doi.org/10.1016/j.jocn.2014.01.009
Prummel, M. F., & Wiersinga, W. M. (1993). Smoking and risk of Graves’ disease. JAMA: The Journal of the American Medical Association, 269(4), 479–482. https://doi.org/10.1001/jama.1993.03500040045034
Fujinami, R. S., von Herrath, M. G., Christen, U., & Whitton, J. L. (2006). Molecular mimicry, bystander activation, or viral persistence: infections and autoimmune disease. Clinical Microbiology Reviews, 19(1), 80–94. https://doi.org/10.1128/CMR.19.1.80-94.2006
Pacheco, Y., Acosta-Ampudia, Y., Monsalve, D. M., Chang, C., Gershwin, M. E., & Anaya, J.-M. (2019). Bystander activation and autoimmunity. Journal of Autoimmunity, 103(102301), 102301. https://doi.org/10.1016/j.jaut.2019.06.012
Gómez-Rial, J., Rivero-Calle, I., Salas, A., & Martinón-Torres, F. (2020). Rotavirus and autoimmunity. The Journal of Infection, 81(2), 183–189. https://doi.org/10.1016/j.jinf.2020.04.041
Pordeus, V., Szyper-Kravitz, M., Levy, R. A., Vaz, N. M., & Shoenfeld, Y. (2008). Infections and autoimmunity: a panorama. Clinical Reviews in Allergy & Immunology, 34(3), 283–299. https://doi.org/10.1007/s12016-007-8048-8
Stene, L. C., Honeyman, M. C., Hoffenberg, E. J., Haas, J. E., Sokol, R. J., Emery, L., Taki, I., Norris, J. M., Erlich, H. A., Eisenbarth, G. S., & Rewers, M. (2006). Rotavirus infection frequency and risk of celiac disease autoimmunity in early childhood: a longitudinal study. The American Journal of Gastroenterology, 101(10), 2333–2340. https://doi.org/10.1111/j.1572-0241.2006.00741.x
Hemming-Harlo, M., Lähdeaho, M.-L., Mäki, M., & Vesikari, T. (2019). Rotavirus vaccination does not increase type 1 diabetes and may decrease celiac disease in children and adolescents. The Pediatric Infectious Disease Journal, 38(5), 539–541. https://doi.org/10.1097/INF.0000000000002281
Levin, L. I., Munger, K. L., Rubertone, M. V., Peck, C. A., Lennette, E. T., Spiegelman, D., & Ascherio, A. (2005). Temporal relationship between elevation of epstein-barr virus antibody titers and initial onset of neurological symptoms in multiple sclerosis. JAMA: The Journal of the American Medical Association, 293(20), 2496–2500. https://doi.org/10.1001/jama.293.20.2496
Farrell, R. A., Antony, D., Wall, G. R., Clark, D. A., Fisniku, L., Swanton, J., Khaleeli, Z., Schmierer, K., Miller, D. H., & Giovannoni, G. (2009). Humoral immune response to EBV in multiple sclerosis is associated with disease activity on MRI. Neurology, 73(1), 32–38. https://doi.org/10.1212/WNL.0b013e3181aa29fe
Xuan, J., Ji, Z., Wang, B., Zeng, X., Chen, R., He, Y., Rao, P., Wu, P., & Shi, G. (2020). Serological evidence for the association between Epstein-Barr virus infection and Sjögren’s syndrome. Frontiers in Immunology, 11, 590444. https://doi.org/10.3389/fimmu.2020.590444
Jeremiah, S. S., Moin, A. S. M., & Butler, A. E. (2024). Virus-induced diabetes mellitus: revisiting infection etiology in light of SARS-CoV-2. Metabolism: Clinical and Experimental, 156(155917), 155917. https://doi.org/10.1016/j.metabol.2024.155917
Unsworth, R., Wallace, S., Oliver, N. S., Yeung, S., Kshirsagar, A., Naidu, H., Kwong, R. M. W., Kumar, P., & Logan, K. M. (2020). New-onset type 1 diabetes in children during COVID-19: Multicenter regional findings in the U.k. Diabetes Care, 43(11), e170–e171. https://doi.org/10.2337/dc20-1551
(N.d.-e). Jamanetwork.com. Retrieved November 22, 2025, from https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2796649
Terracina, S., Caronti, B., Lucarelli, M., Francati, S., Piccioni, M. G., Tarani, L., Ceccanti, M., Caserta, M., Verdone, L., Venditti, S., Fiore, M., & Ferraguti, G. (2025). Alcohol Consumption and Autoimmune Diseases. International Journal of Molecular Sciences, 26(2), 845. https://doi.org/10.3390/ijms26020845
Caslin, B., Mohler, K., Thiagarajan, S., & Melamed, E. (2021). Alcohol as friend or foe in autoimmune diseases: a role for gut microbiome? Gut Microbes, 13(1), 1916278. https://doi.org/10.1080/19490976.2021.1916278
Carlé, A., Pedersen, I. B., Knudsen, N., Perrild, H., Ovesen, L., Rasmussen, L. B., Jørgensen, T., & Laurberg, P. (2012). Moderate alcohol consumption may protect against overt autoimmune hypothyroidism: a population-based case-control study. European Journal of Endocrinology, 167(4), 483–490. https://doi.org/10.1530/EJE-12-0356
Carlé, A., Bülow Pedersen, I., Knudsen, N., Perrild, H., Ovesen, L., Rasmussen, L. B., Jørgensen, T., & Laurberg, P. (2013). Graves’ hyperthyroidism and moderate alcohol consumption: evidence for disease prevention. Clinical Endocrinology, 79(1), 111–119. https://doi.org/10.1111/cen.12106
Lu, B., Solomon, D. H., Costenbader, K. H., & Karlson, E. W. (2014). Alcohol consumption and risk of incident rheumatoid arthritis in women: a prospective study: Alcohol consumption and risk of RA. Arthritis & Rheumatology, 66(8), 1998–2005. https://doi.org/10.1002/art.38634
Jin, Z., Xiang, C., Cai, Q., Wei, X., & He, J. (2014). Alcohol consumption as a preventive factor for developing rheumatoid arthritis: a dose-response meta-analysis of prospective studies. Annals of the Rheumatic Diseases, 73(11), 1962–1967. https://doi.org/10.1136/annrheumdis-2013-203323
Hedström, A. K., Hössjer, O., Klareskog, L., & Alfredsson, L. (2019). Interplay between alcohol, smoking and HLA genes in RA aetiology. RMD Open, 5(1), e000893. https://doi.org/10.1136/rmdopen-2019-000893
VanEvery, H., Yang, W., Olsen, N., Bao, L., Lu, B., Wu, S., Cui, L., & Gao, X. (2021). Alcohol consumption and risk of rheumatoid arthritis among Chinese adults: A prospective study. Nutrients, 13(7), 2231. https://doi.org/10.3390/nu13072231
Mangnus, L., van Steenbergen, H. W., Nieuwenhuis, W. P., Reijnierse, M., & van der Helm-van Mil, A. H. M. (2018). Moderate use of alcohol is associated with lower levels of C reactive protein but not with less severe joint inflammation: a cross-sectional study in early RA and healthy volunteers. RMD Open, 4(1), e000577. https://doi.org/10.1136/rmdopen-2017-000577
Liu, T., Xu, C., Driban, J. B., McAlindon, T., Eaton, C. B., & Lu, B. (2022). Excessive alcohol consumption and the risk of knee osteoarthritis: a prospective study from the Osteoarthritis Initiative. Osteoarthritis and Cartilage, 30(5), 697–701. https://doi.org/10.1016/j.joca.2022.01.011
Rasouli, B., Ahlbom, A., Andersson, T., Grill, V., Midthjell, K., Olsson, L., & Carlsson, S. (2013). Alcohol consumption is associated with reduced risk of Type 2 diabetes and autoimmune diabetes in adults: results from the Nord-Trøndelag health study: Alcohol consumption, Type 2 diabetes and autoimmune diabetes. Diabetic Medicine: A Journal of the British Diabetic Association, 30(1), 56–64. https://doi.org/10.1111/j.1464-5491.2012.03713.x
Bendtsen, P., Grønbaek, M., Kjaer, S. K., Munk, C., Linneberg, A., & Tolstrup, J. S. (2008). Alcohol consumption and the risk of self-reported perennial and seasonal allergic rhinitis in young adult women in a population-based cohort study. Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology, 38(7), 1179–1185. https://doi.org/10.1111/j.1365-2222.2008.02945.x
He, Y., Xu, Y., & Lin, Z. (2025). Association between alcohol consumption and allergic rhinitis in US adults. Frontiers in Nutrition, 12, 1544889. https://doi.org/10.3389/fnut.2025.1544889
Obesity and overweight. (n.d.). Who.int. Retrieved from https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight
World obesity atlas 2025. (n.d.). World Obesity Federation. Retrieved from https://www.worldobesity.org/resources/resource-library/world-obesity-atlas-2025
Cao, H. (2014). Adipocytokines in obesity and metabolic disease. Journal of Endocrinology, 220(2), T47-T59. Retrieved from https://doi.org/10.1530/JOE-13-0339
Versini, M., Jeandel, P.-Y., Rosenthal, E., & Shoenfeld, Y. (2014). Obesity in autoimmune diseases: not a passive bystander. Autoimmunity Reviews, 13(9), 981–1000. https://doi.org/10.1016/j.autrev.2014.07.001
Symmons, D. P., Bankhead, C. R., Harrison, B. J., Brennan, P., Barrett, E. M., Scott, D. G., & Silman, A. J. (1997). Blood transfusion, smoking, and obesity as risk factors for the development of rheumatoid arthritis: results from a primary care-based incident case-control study in Norfolk, England. Arthritis and Rheumatism, 40(11), 1955–1961. https://doi.org/10.1002/art.1780401106
Pedersen, M., Jacobsen, S., Klarlund, M., Pedersen, B. V., Wiik, A., Wohlfahrt, J., & Frisch, M. (2006). Environmental risk factors differ between rheumatoid arthritis with and without auto-antibodies against cyclic citrullinated peptides. Arthritis Research & Therapy, 8(4), R133. https://doi.org/10.1186/ar2022
Lahiri, M., Morgan, C., Symmons, D. P. M., & Bruce, I. N. (2012). Modifiable risk factors for RA: prevention, better than cure? Rheumatology (Oxford, England), 51(3), 499–512. https://doi.org/10.1093/rheumatology/ker299
de Hair, M. J. H., Landewé, R. B. M., van de Sande, M. G. H., van Schaardenburg, D., van Baarsen, L. G. M., Gerlag, D. M., & Tak, P. P. (2013). Smoking and overweight determine the likelihood of developing rheumatoid arthritis. Annals of the Rheumatic Diseases, 72(10), 1654–1658. https://doi.org/10.1136/annrheumdis-2012-202254
Crowson, C. S., Matteson, E. L., Davis, J. M., 3rd, & Gabriel, S. E. (2013). Contribution of obesity to the rise in incidence of rheumatoid arthritis. Arthritis Care & Research, 65(1), 71–77. https://doi.org/10.1002/acr.21660
Lu, B., Hiraki, L. T., Sparks, J. A., Malspeis, S., Chen, C.-Y., Awosogba, J. A., Arkema, E. V., Costenbader, K. H., & Karlson, E. W. (2014). Being overweight or obese and risk of developing rheumatoid arthritis among women: a prospective cohort study. Annals of the Rheumatic Diseases, 73(11), 1914–1922. https://doi.org/10.1136/annrheumdis-2014-205459
Ajeganova, S., Andersson, M. L., Hafström, I., & BARFOT Study Group. (2013). Association of obesity with worse disease severity in rheumatoid arthritis as well as with comorbidities: a long-term followup from disease onset. Arthritis Care & Research, 65(1), 78–87. https://doi.org/10.1002/acr.21710
Cozier, Y. C., Barbhaiya, M., Castro-Webb, N., Conte, C., Tedeschi, S., Leatherwood, C., Costenbader, K. H., & Rosenberg, L. (2019). A prospective study of obesity and risk of systemic lupus erythematosus (SLE) among Black women. Seminars in Arthritis and Rheumatism, 48(6), 1030–1034. https://doi.org/10.1016/j.semarthrit.2018.10.004
Rizk, A., Gheita, T. A., Nassef, S., & Abdallah, A. (2012). The impact of obesity in systemic lupus erythematosus on disease parameters, quality of life, functional capacity and the risk of atherosclerosis: Obesity in SLE. International Journal of Rheumatic Diseases, 15(3), 261–267. https://doi.org/10.1111/j.1756-185X.2011.01698.x
Munger, K. L., Chitnis, T., & Ascherio, A. (2009). Body size and risk of MS in two cohorts of US women. Neurology, 73(19), 1543–1550. https://doi.org/10.1212/WNL.0b013e3181c0d6e0
Munger, K. L., Bentzen, J., Laursen, B., Stenager, E., Koch-Henriksen, N., Sørensen, T. I. A., & Baker, J. L. (2013). Childhood body mass index and multiple sclerosis risk: a long-term cohort study. Multiple Sclerosis (Houndmills, Basingstoke, England), 19(10), 1323–1329. https://doi.org/10.1177/1352458513483889
Langer-Gould, A., Brara, S. M., Beaber, B. E., & Koebnick, C. (2013). Childhood obesity and risk of pediatric multiple sclerosis and clinically isolated syndrome. Neurology, 80(6), 548–552. https://doi.org/10.1212/WNL.0b013e31828154f3
Setty, A. R., Curhan, G., & Choi, H. K. (2007). Obesity, waist circumference, weight change, and the risk of psoriasis in women: Nurses’ Health Study II: Nurses’ health study II. Archives of Internal Medicine, 167(15), 1670–1675. https://doi.org/10.1001/archinte.167.15.1670
Kumar, S., Han, J., Li, T., & Qureshi, A. A. (2013). Obesity, waist circumference, weight change and the risk of psoriasis in US women: Risk of psoriasis in US women. Journal of the European Academy of Dermatology and Venereology: JEADV, 27(10), 1293–1298. https://doi.org/10.1111/jdv.12001
Li, W., Han, J., & Qureshi, A. A. (2012). Obesity and risk of incident psoriatic arthritis in US women. Annals of the Rheumatic Diseases, 71(8), 1267–1272. https://doi.org/10.1136/annrheumdis-2011-201273
Love, T. J., Zhu, Y., Zhang, Y., Wall-Burns, L., Ogdie, A., Gelfand, J. M., & Choi, H. K. (2012). Obesity and the risk of psoriatic arthritis: a population-based study. Annals of the Rheumatic Diseases, 71(8), 1273–1277. https://doi.org/10.1136/annrheumdis-2012-201299
Debbaneh, M., Millsop, J. W., Bhatia, B. K., Koo, J., & Liao, W. (2014). Diet and psoriasis, part I: Impact of weight loss interventions. Journal of the American Academy of Dermatology, 71(1), 133–140. https://doi.org/10.1016/j.jaad.2014.02.012
Piticchio, T., Frasca, F., Malandrino, P., Trimboli, P., Carrubba, N., Tumminia, A., Vinciguerra, F., & Frittitta, L. (2023). Effect of gluten-free diet on autoimmune thyroiditis progression in patients with no symptoms or histology of celiac disease: a meta-analysis. Frontiers in Endocrinology, 14, 1200372. https://doi.org/10.3389/fendo.2023.1200372
Stoiloudis, P., Kesidou, E., Bakirtzis, C., Sintila, S.-A., Konstantinidou, N., Boziki, M., & Grigoriadis, N. (2022). The role of diet and interventions on multiple sclerosis: A review. Nutrients, 14(6), 1150. https://doi.org/10.3390/nu14061150
Gioia, C., Lucchino, B., Tarsitano, M. G., Iannuccelli, C., & Di Franco, M. (2020). Dietary habits and nutrition in rheumatoid arthritis: Can diet influence disease development and clinical manifestations? Nutrients, 12(5), 1456. https://doi.org/10.3390/nu12051456
Wolter, M., Grant, E. T., Boudaud, M., Steimle, A., Pereira, G. V., Martens, E. C., & Desai, M. S. (2021). Leveraging diet to engineer the gut microbiome. Nature Reviews. Gastroenterology & Hepatology, 18(12), 885–902. https://doi.org/10.1038/s41575-021-00512-7
Ray, C., & Ming, X. (2020). Climate change and human health: A review of allergies, autoimmunity and the microbiome. International Journal of Environmental Research and Public Health, 17(13), 4814. https://doi.org/10.3390/ijerph17134814
Belvoncikova, P., Maronek, M., & Gardlik, R. (2022). Gut dysbiosis and fecal Microbiota transplantation in autoimmune diseases. International Journal of Molecular Sciences, 23(18), 10729. https://doi.org/10.3390/ijms231810729
Gohari, A., Baumann, B., Jen, R., & Ayas, N. (2022). Sleep deficiency: Epidemiology and effects. Clinics in Chest Medicine, 43(2), 189–198. https://doi.org/10.1016/j.ccm.2022.02.001
Hsiao, Y.-H., Chen, Y.-T., Tseng, C.-M., Wu, L.-A., Lin, W.-C., Su, V. Y.-F., Perng, D.-W., Chang, S.-C., Chen, Y.-M., Chen, T.-J., Lee, Y.-C., & Chou, K.-T. (2015). Sleep disorders and increased risk of autoimmune diseases in individuals without sleep apnea. Sleep, 38(4), 581–586. https://doi.org/10.5665/sleep.4574
Garbarino, S., Lanteri, P., Bragazzi, N. L., Magnavita, N., & Scoditti, E. (2021). Role of sleep deprivation in immune-related disease risk and outcomes. Communications Biology, 4(1), 1304. https://doi.org/10.1038/s42003-021-02825-4
Seo, H.-M., Kim, T. L., & Kim, J. S. (2018). The risk of alopecia areata and other related autoimmune diseases in patients with sleep disorders: a Korean population-based retrospective cohort study. Sleep, 41(9). https://doi.org/10.1093/sleep/zsy111
Palma, B. D., Gabriel, A., Jr, Colugnati, F. A. B., & Tufik, S. (2006). Effects of sleep deprivation on the development of autoimmune disease in an experimental model of systemic lupus erythematosus. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 291(5), R1527-32. https://doi.org/10.1152/ajpregu.00186.2006
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