TELEMEDICINE IN MULTIPLE SCLEROSIS MANAGEMENT - A LITERATURE REVIEW
Abstract
Introduction: Telemedicine has gained importance in recent years as an essential element of care for patients with multiple sclerosis (MS), particularly during the COVID-19 pandemic, which has accelerated the development of digital tools and remote forms of support. Considering the chronic nature of MS and the need for regular symptom monitoring, telemedicine solutions are a valuable adjunct to traditional neurological care.
Methods: This review aims to present the current possibilities for the use of telemedicine in MS, including remote neurological consultations, the use of wearable devices for functional monitoring, telerehabilitation, and online forms of psychological support. Publications from recent years available in the Pubmed database describing telemedicine tools, their capabilities, effectiveness, and limitations were analyzed.
Results: Current evidence suggests that online consultations may constitute a viable alternative to in-person visits, improving access to care and satisfaction among patients. E-diaries do not increase medication adherence, suggesting that this tool has restricted efficacy in improving compliance. Wearable devices enable continuous monitoring of patients' functioning in everyday life. Telerehabilitation has been shown to be effective in improving physical functioning, balance, respiratory and cognitive functions. Some online psychological interventions have also been shown to be effective, particularly in reducing symptoms of depression and anxiety.
Conclusions: Telemedicine provides valuable support for the care of patients with MS, offering benefits in disease monitoring, rehabilitation, and psychological support. However, further high-quality research is needed to optimize its use and identify areas for development.
References
Reich DS, Lucchinetti CF, Calabresi PA. Multiple Sclerosis. N Engl J Med. 2018 Jan 11;378(2):169-180. doi: 10.1056/NEJMra1401483. PMID: 29320652; PMCID: PMC6942519.
Yeroushalmi S, Maloni H, Costello K, Wallin MT. Telemedicine and multiple sclerosis: A comprehensive literature review. J Telemed Telecare. 2020 Aug-Sep;26(7-8):400-413. doi: 10.1177/1357633X19840097. Epub 2019 May 1. PMID: 31042118.
Krett JD, Salter A, Newsome SD. Era of COVID-19 in Multiple Sclerosis Care. Neurol Clin. 2024 Feb;42(1):319-340. doi: 10.1016/j.ncl.2023.06.006. Epub 2023 Jun 23. PMID: 37980121; PMCID: PMC10288315.
Howard IM, Burgess K. Telehealth for Amyotrophic Lateral Sclerosis and Multiple Sclerosis. Phys Med Rehabil Clin N Am. 2021 May;32(2):239-251. doi: 10.1016/j.pmr.2020.12.003. Epub 2021 Jan 26. PMID: 33814055.
McGinley MP, Ontaneda D, Wang Z, Weber M, Shook S, Stanton M, Bermel R. Teleneurology as a Solution for Outpatient Care During the COVID-19 Pandemic. Telemed J E Health. 2020 Dec;26(12):1537-1539. doi: 10.1089/tmj.2020.0137. Epub 2020 Jun 16. PMID: 32552509; PMCID: PMC7757521.
Feigin VL, Vos T, Nichols E, Owolabi MO, Carroll WM, Dichgans M, Deuschl G, Parmar P, Brainin M, Murray C. The global burden of neurological disorders: translating evidence into policy. Lancet Neurol. 2020 Mar;19(3):255-265. doi: 10.1016/S1474-4422(19)30411-9. Epub 2019 Dec 5. PMID: 31813850; PMCID: PMC9945815.
Walton C, King R, Rechtman L, Kaye W, Leray E, Marrie RA, Robertson N, La Rocca N, Uitdehaag B, van der Mei I, Wallin M, Helme A, Angood Napier C, Rijke N, Baneke P. Rising prevalence of multiple sclerosis worldwide: Insights from the Atlas of MS, third edition. Mult Scler. 2020 Dec;26(14):1816-1821. doi: 10.1177/1352458520970841. Epub 2020 Nov 11. PMID: 33174475; PMCID: PMC7720355.
Lejbkowicz I, Paperna T, Stein N, Dishon S, Miller A. Internet usage by patients with multiple sclerosis: implications to participatory medicine and personalized healthcare. Mult Scler Int. 2010;2010:640749. doi: 10.1155/2010/640749. Epub 2010 Jun 30. PMID: 22096625; PMCID: PMC3196922.
Sadeghi N, Eelen P, Nagels G, Cuvelier C, Van Gils K, D'hooghe MB, Van Schependom J, D'haeseleer M. Innovating Care in Multiple Sclerosis: Feasibility of Synchronous Internet-Based Teleconsultation for Longitudinal Clinical Monitoring. J Pers Med. 2022 Mar 10;12(3):433. doi: 10.3390/jpm12030433. PMID: 35330433; PMCID: PMC8948780.
Bove R, Bevan C, Crabtree E, Zhao C, Gomez R, Garcha P, Morrissey J, Dierkhising J, Green AJ, Hauser SL, Cree BA, Wallin MT, Gelfand JM. Toward a low-cost, in-home, telemedicine-enabled assessment of disability in multiple sclerosis. Mult Scler. 2019 Oct;25(11):1526-1534. doi: 10.1177/1352458518793527. Epub 2018 Aug 24. PMID: 30141729.
Moccia M, Lanzillo R, Brescia Morra V, Bonavita S, Tedeschi G, Leocani L, Lavorgna L; Digital Technologies Web and Social Media Study Group of the Italian Society of Neurology. Assessing disability and relapses in multiple sclerosis on tele-neurology. Neurol Sci. 2020 Jun;41(6):1369-1371. doi: 10.1007/s10072-020-04470-x. Epub 2020 May 21. PMID: 32440979; PMCID: PMC7241064.
Learmonth YC, Motl RW, Sandroff BM, Pula JH, Cadavid D. Validation of patient determined disease steps (PDDS) scale scores in persons with multiple sclerosis. BMC Neurol. 2013 Apr 25;13:37. doi: 10.1186/1471-2377-13-37. PMID: 23617555; PMCID: PMC3651716.
Vacchi L, Zirone E, Strina V, Cavaletti G, Ferrarese C. Mobile Applications to Support Multiple Sclerosis Communities: The Post-COVID-19 Scenario. Telemed J E Health. 2024 Jun;30(6):e1615-e1628. doi: 10.1089/tmj.2023.0515. Epub 2024 Mar 7. PMID: 38452336.
Golan D, Sagiv S, Glass-Marmor L, Miller A. Mobile phone-based e-diary for assessment and enhancement of medications adherence among patients with multiple sclerosis. Mult Scler J Exp Transl Clin. 2020 Aug 14;6(3):2055217320939309. doi: 10.1177/2055217320939309. PMID: 32864155; PMCID: PMC7430083.
Matthews PM, Block VJ, Leocani L. E-health and multiple sclerosis. Curr Opin Neurol. 2020 Jun;33(3):271-276. doi: 10.1097/WCO.0000000000000823. PMID: 32324706.
Yousef A, Jonzzon S, Suleiman L, Arjona J, Graves JS. Biosensing in multiple sclerosis. Expert Rev Med Devices. 2017 Nov;14(11):901-912. doi: 10.1080/17434440.2017.1388162. Epub 2017 Oct 23. PMID: 28975814.
Lavorgna L, Brigo F, Moccia M, Leocani L, Lanzillo R, Clerico M, Abbadessa G, Schmierer K, Solaro C, Prosperini L, Tedeschi G, Giovannoni G, Bonavita S. e-Health and multiple sclerosis: An update. Mult Scler. 2018 Nov;24(13):1657-1664. doi: 10.1177/1352458518799629. Epub 2018 Sep 19. PMID: 30231004.
Graves JS, Montalban X. Biosensors to monitor MS activity. Mult Scler. 2020 Apr;26(5):605-608. doi: 10.1177/1352458519888178. Epub 2020 Jan 22. PMID: 31965896.
Salaorni F, Bonardi G, Schena F, Tinazzi M, Gandolfi M. Wearable devices for gait and posture monitoring via telemedicine in people with movement disorders and multiple sclerosis: a systematic review. Expert Rev Med Devices. 2024 Jan-Feb;21(1-2):121-140. doi: 10.1080/17434440.2023.2298342. Epub 2024 Feb 4. PMID: 38124300.
Kumar G, Kaur D, Singh AK. Can tele-physiotherapy help in filling treatment gaps during pandemics in multiple sclerosis? J Family Med Prim Care. 2024 Oct;13(10):4510-4516. doi: 10.4103/jfmpc.jfmpc_204_24. Epub 2024 Oct 18. PMID: 39629369; PMCID: PMC11610888.
Rintala A, Hakala S, Paltamaa J, Heinonen A, Karvanen J, Sjögren T. Effectiveness of technology-based distance physical rehabilitation interventions on physical activity and walking in multiple sclerosis: a systematic review and meta-analysis of randomized controlled trials. Disabil Rehabil. 2018 Feb;40(4):373-387. doi: 10.1080/09638288.2016.1260649. Epub 2016 Dec 15. PMID: 27973919.
Ayçiçek ŞÖ, Tunç A, Bağcı C. Effects of Telehealth-Supervised Respiratory Exercise Training on Respiratory Function, Fatigue, Quality of Life, and Functional Capacity of Patients with Multiple Sclerosis. Medicina (Kaunas). 2025 Apr 2;61(4):651. doi: 10.3390/medicina61040651. PMID: 40282942; PMCID: PMC12028881.
Deodato M, Fornasaro M, Martini M, Zelesnich F, Sartori A, Galmonte A, Buoite Stella A, Manganotti P. Comparison of different telerehabilitation protocols for urogenital symptoms in females with multiple sclerosis: a randomized controlled trial. Neurol Sci. 2024 Nov;45(11):5501-5509. doi: 10.1007/s10072-024-07742-y. Epub 2024 Sep 3. PMID: 39223424; PMCID: PMC11470853.
Kamm CP, Kueng R, Blättler R. Development of a new immersive virtual reality (VR) headset-based dexterity training for patients with multiple sclerosis: Clinical and technical aspects. Technol Health Care. 2024;32(2):1067-1078. doi: 10.3233/THC-230541. PMID: 37545286; PMCID: PMC10977399.
Gutiérrez RO, Galán Del Río F, Cano de la Cuerda R, Alguacil Diego IM, González RA, Page JC. A telerehabilitation program by virtual reality-video games improves balance and postural control in multiple sclerosis patients. NeuroRehabilitation. 2013;33(4):545-54. doi: 10.3233/NRE-130995. PMID: 24029009.
Robinson J, Dixon J, Macsween A, van Schaik P, Martin D. The effects of exergaming on balance, gait, technology acceptance and flow experience in people with multiple sclerosis: a randomized controlled trial. BMC Sports Sci Med Rehabil. 2015 Apr 17;7:8. doi: 10.1186/s13102-015-0001-1. PMID: 25969739; PMCID: PMC4427959.
Potagas C, Giogkaraki E, Koutsis G, Mandellos D, Tsirempolou E, Sfagos C, Vassilopoulos D. Cognitive impairment in different MS subtypes and clinically isolated syndromes. J Neurol Sci. 2008 Apr 15;267(1-2):100-6. doi: 10.1016/j.jns.2007.10.002. Epub 2007 Nov 13. PMID: 17997417.
Stanmore E, Stubbs B, Vancampfort D, de Bruin ED, Firth J. The effect of active video games on cognitive functioning in clinical and non-clinical populations: A meta-analysis of randomized controlled trials. Neurosci Biobehav Rev. 2017 Jul;78:34-43. doi: 10.1016/j.neubiorev.2017.04.011. Epub 2017 Apr 23. PMID: 28442405.
Ghadiri F, Naser Moghadasi A, Sahraian MA. Telemedicine as a strategic intervention for cognitive rehabilitation in MS patients during COVID-19. Acta Neurol Belg. 2022 Feb;122(1):23-29. doi: 10.1007/s13760-022-01875-7. Epub 2022 Jan 30. PMID: 35094365; PMCID: PMC8801040.
Messinis L, Nasios G, Kosmidis MH, Zampakis P, Malefaki S, Ntoskou K, Nousia A, Bakirtzis C, Grigoriadis N, Gourzis P, Papathanasopoulos P. Efficacy of a Computer-Assisted Cognitive Rehabilitation Intervention in Relapsing-Remitting Multiple Sclerosis Patients: A Multicenter Randomized Controlled Trial. Behav Neurol. 2017;2017:5919841. doi: 10.1155/2017/5919841. Epub 2017 Dec 31. PMID: 29463950; PMCID: PMC5804109.
Chiaravalloti ND, Goverover Y, Costa SL, DeLuca J. A Pilot Study Examining Speed of Processing Training (SPT) to Improve Processing Speed in Persons With Multiple Sclerosis. Front Neurol. 2018 Aug 27;9:685. doi: 10.3389/fneur.2018.00685. PMID: 30210426; PMCID: PMC6119725.
Siegert RJ, Abernethy DA. Depression in multiple sclerosis: a review. J Neurol Neurosurg Psychiatry. 2005 Apr;76(4):469-75. doi: 10.1136/jnnp.2004.054635. PMID: 15774430; PMCID: PMC1739575.
Proctor BJ, Moghaddam N, Vogt W, das Nair R. Telephone psychotherapy in multiple sclerosis: A systematic review and meta-analysis. Rehabil Psychol. 2018 Feb;63(1):16-28. doi: 10.1037/rep0000182. PMID: 29553780.
Mohamadpour F. Effectiveness of compassion-based online therapy on suicidal thoughts and pain catastrophizing in female patients with multiple sclerosis in the relapsing-remitting phase. Front Psychol. 2023 Dec 11;14:1128308. doi: 10.3389/fpsyg.2023.1128308. PMID: 38146401; PMCID: PMC10749302.
Giovannetti AM, Quintas R, Maggiolo S, Quartuccio ME. Online mindfulness program (COndiVIDere) for people with multiple sclerosis in the time of COVID-19: a pilot longitudinal study. Disabil Rehabil. 2024 Oct;46(21):4956-4964. doi: 10.1080/09638288.2023.2290690. Epub 2023 Dec 3. PMID: 38042990.
Cavalera C, Rovaris M, Mendozzi L, Pugnetti L, Garegnani M, Castelnuovo G, Molinari E, Pagnini F. Online meditation training for people with multiple sclerosis: A randomized controlled trial. Mult Scler. 2019 Apr;25(4):610-617. doi: 10.1177/1352458518761187. Epub 2018 Feb 27. PMID: 29485319.
Robb JF, Hyland MH, Goodman AD. Comparison of telemedicine versus in-person visits for persons with multiple sclerosis: A randomized crossover study of feasibility, cost, and satisfaction. Mult Scler Relat Disord. 2019 Nov;36:101258. doi: 10.1016/j.msard.2019.05.001. Epub 2019 May 6. PMID: 31472419.
Landi D, Ponzano M, Nicoletti CG, Cola G, Cecchi G, Grimaldi A, Mataluni G, Mercuri NB, Sormani MP, Pacileo G, Marfia GA. Patient's point of view on the use of telemedicine in multiple sclerosis: a web-based survey. Neurol Sci. 2022 Feb;43(2):1197-1205. doi: 10.1007/s10072-021-05398-6. Epub 2021 Jul 20. PMID: 34283343; PMCID: PMC8289711.
Marrie RA, Leung S, Tyry T, Cutter GR, Fox R, Salter A. Use of eHealth and mHealth technology by persons with multiple sclerosis. Mult Scler Relat Disord. 2019 Jan;27:13-19. doi: 10.1016/j.msard.2018.09.036. Epub 2018 Oct 2. PMID: 30296732.
Marrie RA, Kosowan L, Cutter G, Fox R, Salter A. Disparities in Telehealth Care in Multiple Sclerosis. Neurol Clin Pract. 2022 Jun;12(3):223-233. doi: 10.1212/CPJ.0000000000001167. PMID: 35747551; PMCID: PMC9208413.
Keszler P, Maloni H, Miles Z, Jin S, Wallin M. Telemedicine and Multiple Sclerosis: A Survey of Health Care Providers Before and During the COVID-19 Pandemic. Int J MS Care. 2022 Nov-Dec;24(6):266-270. doi: 10.7224/1537-2073.2021-103. Epub 2022 Sep 15. PMID: 36545646; PMCID: PMC9749831.
Chirra M, Marsili L, Wattley L, Sokol LL, Keeling E, Maule S, Sobrero G, Artusi CA, Romagnolo A, Zibetti M, Lopiano L, Espay AJ, Obeidat AZ, Merola A. Telemedicine in Neurological Disorders: Opportunities and Challenges. Telemed J E Health. 2019 Jul;25(7):541-550. doi: 10.1089/tmj.2018.0101. Epub 2018 Aug 23. PMID: 30136898; PMCID: PMC6664824.
Shaw MT, Best P, Frontario A, Charvet LE. Telerehabilitation benefits patients with multiple sclerosis in an urban setting. J Telemed Telecare. 2021 Jan;27(1):39-45. doi: 10.1177/1357633X19861830. Epub 2019 Jul 15. PMID: 31307269.
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