THE ROLE OF DIGITAL THERAPEUTICS IN THE MANAGEMENT OF MYOFASCIAL PAIN SYNDROME: A COMPREHENSIVE REVIEW

Keywords: Myofascial Pain Syndrome, Digital Therapeutics, Telehealth, Mobile Health, Virtual Reality, Wearables, Chronic Musculoskeletal Pain

Abstract

Background: Myofascial Pain Syndrome (MPS) is a prevalent musculoskeletal condition involving trigger points, chronic pain, and functional limitations. Digital therapeutics (DTx) have gained attention as accessible tools that support rehabilitation and self-management in chronic pain.

Purpose of Research: This review aimed to synthesize current evidence on the clinical usefulness of digital interventions—such as telehealth, mobile applications, virtual reality, and wearable sensors—in the management of MPS and related myofascial pain.

Materials and Methods: A systematic review was performed according to PRISMA 2020. Searches across major databases identified studies evaluating digital therapeutics for MPS or chronic musculoskeletal pain with myofascial components. Eligible study designs included randomized trials, quasi-experimental studies, cohort studies, and systematic reviews. Two reviewers independently conducted screening, data extraction, risk-of-bias assessment (RoB2, ROBINS-I, AMSTAR 2), and evaluation of evidence certainty using GRADE.

Results: Digital interventions generally reduced pain, improved function, and supported adherence to therapeutic exercises. Telehealth physiotherapy and app-based rehabilitation showed effectiveness comparable to traditional in-person care. Virtual reality contributed to greater engagement and reductions in pain-related fear, while wearable sensors enhanced monitoring and promoted consistent home-based activity. Together, these tools improved self-management and complemented standard physiotherapy approaches.

Conclusion: Digital therapeutics provide a valuable adjunct in managing Myofascial Pain Syndrome, offering flexible, personalized, and patient-centered care. Although current evidence is promising, more high-quality MPS-specific randomized trials are needed to refine clinical guidance.

References

Giamberardino, M. A., Affaitati, G., Fabrizio, A., & Costantini, R. (2011). Myofascial pain syndromes and their evaluation. Best Practice & Research Clinical Rheumatology, 25(2), 185–198. https://doi.org/10.1016/j.berh.2011.01.002

Cerezo-Téllez, E., Torres-Lacomba, M., Mayoral-del Moral, O., et al. (2016). Prevalence of myofascial pain syndrome in chronic non-specific neck pain: A population-based cross-sectional descriptive study. Pain Medicine, 17(12), 2369–2377. https://doi.org/10.1093/pm/pnw114

Steen, J. P., Jaiswal, K. S., Kumbhare, D., et al. (2025). Myofascial pain syndrome: An update on clinical characteristics, etiopathogenesis, diagnosis, and treatment. Muscle & Nerve. https://doi.org/10.1002/mus.28377

Bunting, J. W., Greaves, C. J., et al. (2021). Digital interventions for promoting exercise adherence in chronic musculoskeletal pain: A systematic review and meta-analysis. Physiotherapy, 111, 23–30. https://doi.org/10.1016/j.physio.2020.08.001

de Araújo Vieira, L. M. S. M., de Andrade, M. A., & Sato, T. O. (2023). Telerehabilitation for musculoskeletal pain: An overview of systematic reviews. Digital Health, 9, Article 20552076231164242. https://doi.org/10.1177/20552076231164242

Hong, J. S., Wasden, C., & Han, D. H. (2021). Introduction of digital therapeutics. Computer Methods and Programs in Biomedicine, 209, 106319. https://doi.org/10.1016/j.cmpb.2021.106319

Alahmri, F., et al. (2024). Effectiveness of telerehabilitation on pain and function in musculoskeletal disorders: A systematic review of randomized controlled trials. Musculoskeletal Care. https://doi.org/10.1002/msc.1912

Bailey, J. F., Agarwal, V., Zheng, P., Smuck, M., Fredericson, M., Kennedy, D. J., & Krauss, J. (2020). Digital care for chronic musculoskeletal pain: 10,000 participant longitudinal cohort study. Journal of Medical Internet Research, 22(5), e18250. https://doi.org/10.2196/18250

Viderman, D., Tapinova, K., Dossov, M., Seitenov, S., & Abdildin, Y. G. (2023). Virtual reality for pain management: An umbrella review. Frontiers in Medicine, 10, 1203670. https://doi.org/10.3389/fmed.2023.1203670

Goudman, L., Jansen, J., Billot, M., Vets, N., De Smedt, A., Roulaud, M., Rigoard, P., & Moens, M. (2022). Virtual reality applications in chronic pain management: Systematic review and meta-analysis. JMIR Serious Games, 10(2), e34402. https://doi.org/10.2196/34402

Page, M. J., McKenzie, J. E., Bossuyt, P. M., Boutron, I., Hoffmann, T. C., Mulrow, C. D., … Moher, D. (2021). The PRISMA 2020 statement: An updated guideline for reporting systematic reviews. BMJ, 372, n71. https://doi.org/10.1136/bmj.n71

Booth, A., Clarke, M., Dooley, G., Ghersi, D., Moher, D., Petticrew, M., & Stewart, L. (2012). The nuts and bolts of PROSPERO: An international prospective register of systematic reviews. Systematic Reviews, 1, 2. https://doi.org/10.1186/2046-4053-1-2

Higgins, J. P. T., Thomas, J., Chandler, J., Cumpston, M., Li, T., Page, M. J., & Welch, V. A. (Eds.). (2023). Cochrane handbook for systematic reviews of interventions (Version 6.3). Cochrane. https://training.cochrane.org/handbook

Sterne, J. A. C., Hernán, M. A., Reeves, B. C., Savović, J., Berkman, N. D., Viswanathan, M., … Higgins, J. P. T. (2016). ROBINS-I: A tool for assessing risk of bias in non-randomized studies of interventions. BMJ, 355, i4919. https://doi.org/10.1136/bmj.i4919

Shea, B. J., Reeves, B. C., Wells, G., Thuku, M., Hamel, C., Moran, J., … Henry, D. A. (2017). AMSTAR 2: A critical appraisal tool for systematic reviews that include randomized or non-randomized studies of healthcare interventions, or both. BMJ, 358, j4008. https://doi.org/10.1136/bmj.j4008

Guyatt, G. H., Oxman, A. D., Vist, G. E., Kunz, R., Falck-Ytter, Y., Alonso-Coello, P., Schünemann, H. J., & GRADE Working Group. (2008). GRADE: An emerging consensus on rating quality of evidence and strength of recommendations. BMJ, 336(7650), 924–926. https://doi.org/10.1136/bmj.39489.470347.AD

Valentijn, P. P., Tymchenko, L., Jacobson, T., Kromann, J., Biermann, C. W., AlMoslemany, M. A., Arends, R. Y., et al. (2022). Digital health interventions for musculoskeletal pain conditions: Systematic review and meta-analysis of randomized controlled trials. Journal of Medical Internet Research, 24(9), e37869. https://doi.org/10.2196/37869

Shi, J. L. H., & Sit, R. W. S. (2024). Impact of 25 years of mobile health tools for pain management in patients with chronic musculoskeletal pain: Systematic review. Journal of Medical Internet Research, 26, e59358. https://doi.org/10.2196/59358

Rodríguez-Sánchez-Laulhé, P., Heredia-Rizo, A. M., Salas-González, J., Piña-Pozo, F., Fernández-Seguín, L. M., & García-Muñoz, C. (2024). Exploring factors associated with changes in pain and function following mHealth-based exercise therapy for chronic musculoskeletal pain: A systematic review with meta-analysis and meta-regression. Applied Sciences, 14(15), 6632. https://doi.org/10.3390/app14156632

Molina-García, P., Mora-Traverso, M., Prieto-Moreno, R., Díaz-Vásquez, A., Antony, B., & Ariza-Vega, P. (2024). Effectiveness and cost-effectiveness of telerehabilitation for musculoskeletal disorders: A systematic review and meta-analysis. Annals of Physical and Rehabilitation Medicine, 67, 101791. https://doi.org/10.1016/j.rehab.2023.101791

Sumner, J., Lim, H. W., Chong, L. S., Bundele, A., Mukhopadhyay, A., & Kayambu, G. (2023). Artificial intelligence in physical rehabilitation: A systematic review. Artificial Intelligence in Medicine, 146, 102693. https://doi.org/10.1016/j.artmed.2023.102693

Fatoye, F., Gebrye, T., Mbada, C. E., Useh, U., & Olaoye, M. I. (2023). Economic evaluations of digital health interventions for the management of musculoskeletal disorders: Systematic review and meta-analysis. Journal of Medical Internet Research, 25, e41113. https://doi.org/10.2196/41113

Vitali, D., Olugbade, T., Eccleston, C., Keogh, E., Bianchi-Berthouze, N., & Williams, A. C. de C. (2024). Sensing behaviour change in chronic pain: A scoping review of sensor technology for use in daily life. Pain, 165(6), 1348–1360. https://doi.org/10.1097/j.pain.0000000000003134

Published
2025-12-21
Citations
How to Cite
Michał Pietrucha, Filip Kowal, Kamila Krzyżanowska, Jakub Król, Adrian Dyląg, Monika Dziedzic, Maciej Łydka, Justyna Lewandowska, Natalia Libudzic, & Julia Łaciak. (2025). THE ROLE OF DIGITAL THERAPEUTICS IN THE MANAGEMENT OF MYOFASCIAL PAIN SYNDROME: A COMPREHENSIVE REVIEW. International Journal of Innovative Technologies in Social Science, 4(4(48). https://doi.org/10.31435/ijitss.4(48).2025.4398

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