EXPLORING THE THERAPEUTIC POTENTIAL OF THE MEDICINAL MUSHROOM GANODERMA LUCIDUM (REISHI) - A LITERATURE REVIEW
Abstract
Introduction: Ganoderma lucidum, also known as Reishi, is a medicinal mushroom that has been used for centuries in traditional Asian medicine for its diverse health-promoting properties. Rich in bioactive compounds such as polysaccharides and triterpenoids, G.lucidum exerts various effects such as modulating oxidative stress, inflammation and immune response.
Materials and methods: A systematic search of PubMed and Google Scholar was conducted, using key words and phrases such as “Ganoderma lucidum”, “Reishi”, “properties”, “anticancer”, and “metabolic health”. A total of 22 high-quality, recent studies relevant to this review were selected for inclusion.
Results: This review summarizes evidence on the mushroom's hepatoprotective, neuroprotective, antitumor, cardioprotective, and metabolic effects. Findings from both in vitro and in vivo studies point to its promising role in battling hepatopathies, neurodegenerative disorders, various types of cancer, and metabolic disorders such as dyslipidemia and hypoglycemia.
Conclusion: While favorable data from preclinical studies exists, there remains limited data from clinical trials. This review highlights the need for large-scale well-controlled clinical trials to be conducted in order to establish G. lucidum's efficacy, safety, dosing standards, and potential drug interactions.
References
Seweryn E, Ziała A, Gamian A. Health-Promoting of Polysaccharides Extracted from Ganoderma lucidum. Nutrients. 2021;13(8):2725. doi:https://doi.org/10.3390/nu13082725
Ekiz E, Oz E, Abd El-Aty AM, et al. Exploring the Potential Medicinal Benefits of Ganoderma lucidum: From Metabolic Disorders to Coronavirus Infections. Foods. 2023;12(7):1512. doi:https://doi.org/10.3390/foods12071512
Cör D, Knez Ž, Knez Hrnčič M. Antitumour, Antimicrobial, Antioxidant and Antiacetylcholinesterase Effect of Ganoderma Lucidum Terpenoids and Polysaccharides: A Review. Molecules. 2018;23(3):649. doi:https://doi.org/10.3390/molecules23030649
Cör Andrejč D, Knez Ž, Knez Marevci M. Antioxidant, antibacterial, antitumor, antifungal, antiviral, anti-inflammatory, and nevro-protective activity of Ganoderma lucidum: An overview. Frontiers in Pharmacology. 2022;13. doi:https://doi.org/10.3389/fphar.2022.934982
Ahmad MF, Ahmad FA, Zeyaullah M, et al. Ganoderma lucidum: Novel Insight into Hepatoprotective Potential with Mechanisms of Action. Nutrients. 2023;15(8):1874. doi:https://doi.org/10.3390/nu15081874
Peng H, Zhong L, Cheng L, et al. Ganoderma lucidum: Current advancements of characteristic components and experimental progress in anti-liver fibrosis. Frontiers in Pharmacology. 2023;13. doi:https://doi.org/10.3389/fphar.2022.1094405
Lian W, Yang X, Duan Q, et al. The Biological Activity of Ganoderma lucidum on Neurodegenerative Diseases: The Interplay between Different Active Compounds and the Pathological Hallmarks. Molecules. 2024;29(11):2516-2516. doi:https://doi.org/10.3390/molecules29112516
Chen XJ, Deng Z, Zhang LL, et al. Therapeutic potential of the medicinal mushroom Ganoderma lucidum against Alzheimer’s disease. Biomedicine & Pharmacotherapy. 2024;172:116222-116222. doi:https://doi.org/10.1016/j.biopha.2024.116222
Fijałkowska A, Jędrejko K, Sułkowska-Ziaja K, Ziaja M, Kała K, Muszyńska B. Edible Mushrooms as a Potential Component of Dietary Interventions for Major Depressive Disorder. Foods. 2022;11(10):1489. doi:https://doi.org/10.3390/foods11101489
Chan SW, Tomlinson B, Chan P, Lam CWK. The beneficial effects of Ganoderma lucidum on cardiovascular and metabolic disease risk. Pharmaceutical Biology. 2021;59(1):1161-1171. doi:https://doi.org/10.1080/13880209.2021.1969413
Aref M, Khoshhali M, Ghasemi P, Adeli S, Heidari-Beni M, Kelishadi R. Effect of Ganoderma lucidum on serum lipid profiles: A systematic review and meta-analysis on animal studies. Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences. 2023;28:70. doi:https://doi.org/10.4103/jrms.jrms_175_23
Wang X, Wang X, Zhao L, Zhou F. Clinical Evaluation of Ganoderma lucidum Spore Oil for Triglyceride Reduction: A Randomized, Double-Blind, Crossover Study. Nutrients. 2025;17(5):844. doi:https://doi.org/10.3390/nu17050844
Pazzi F, Adsuar JC, Domínguez-Muñoz FJ, García-Gordillo MÁ, Gusi N, Collado-Mateo D. Nutrición Hospitalaria Trabajo Original Otros. Nutrición Hospitalaria. 2021;2021 Feb 23;38(1):139-145. doi:https://doi.org/10.20960/nh.03190
Dai R, Liu M, Najbah W, Xi Z, Hong X. Mycomedicine: A Unique Class of Natural Products with Potent Anti-tumour Bioactivities. Molecules. 2021;26(4):1113-1113. doi:https://doi.org/10.3390/molecules26041113
Emin Cadar, Ticuta Negreanu-Pirjol, Pascale C, et al. Natural Bio-Compounds from Ganoderma lucidum and Their Beneficial Biological Actions for Anticancer Application: A Review. Antioxidants. 2023;12(11):1907-1907. doi:https://doi.org/10.3390/antiox12111907
Ahmad MF. Ganoderma lucidum: A rational pharmacological approach to surmount cancer. Journal of Ethnopharmacology. 2020;260:113047. doi:https://doi.org/10.1016/j.jep.2020.113047
Cancemi G, Caserta S, Gangemi S, Pioggia G, Allegra A. Exploring the Therapeutic Potential of Ganoderma lucidum in Cancer. Journal of Clinical Medicine. 2024;13(4):1153. doi:https://doi.org/10.3390/jcm13041153
Xu J, Shen R, Jiao Z, et al. Current Advancements in Antitumor Properties and Mechanisms of Medicinal Components in Edible Mushrooms. Nutrients. 2022;14(13):2622. doi:https://doi.org/10.3390/nu14132622
Marzia Bruna Gariboldi, Marras E, Ferrario N, et al. Anti-Cancer Potential of Edible/Medicinal Mushrooms in Breast Cancer. International Journal of Molecular Sciences. 2023;24(12):10120-10120. doi:https://doi.org/10.3390/ijms241210120
Wong JH, Ng TB, Chan HHL, et al. Mushroom extracts and compounds with suppressive action on breast cancer: evidence from studies using cultured cancer cells, tumor-bearing animals, and clinical trials. Applied Microbiology and Biotechnology. 2020;104(11):4675-4703. doi:https://doi.org/10.1007/s00253-020-10476-4
Ye T, Yang G, Jiang X, Song H, Peng C, Liu B. A review of anti-tumour effects of Ganoderma lucidum in gastrointestinal cancer. Chinese Medicine. 2023;18(1). doi:https://doi.org/10.1186/s13020-023-00811-y
Rokos T, Pribulova T, Kozubik E, Biringer K, Holubekova V, Kudela E. Exploring the Bioactive Mycocompounds (Fungal Compounds) of Selected Medicinal Mushrooms and Their Potentials against HPV Infection and Associated Cancer in Humans. Life. 2023;13(1):244. doi:https://doi.org/10.3390/life13010244
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