UNDERSTANDING THE RELATIONSHIP BETWEEN CAFFEINE AND SLEEP - A REVIEW

Keywords: Lack Of Sleep, Daytime Sleepiness, Caffeine Sleep, Caffeine, Sleep Disorders

Abstract

Research objectives: Sleep is a fundamental physiological process essential for the proper functioning of the body and mind. It supports physical restoration, emotional regulation, cognitive performance, and overall health. Due to its complexity, even slight disruptions in sleep patterns can significantly affect well-being. Caffeine is the most widely consumed psychoactive substance worldwide. Found in coffee, tea, energy drinks, and various medications, it is used daily by the majority of the population to enhance alertness and reduce fatigue. Given its popularity and stimulating properties, it is important to examine how caffeine consumption affects sleep.

Methods: A comprehensive literature review was conducted, analyzing 44 studies from the PubMed database (English-language, up to 2025) that assess the relationship between caffeine and sleep.

Key findings: This work reviews existing research on how caffeine intake, particularly in moderate to high doses, influences sleep timing, duration, architecture, and recovery, with a focus on timing of consumption and habitual use.

Conclusions: Caffeine disrupts sleep by reducing total sleep time and altering key sleep stages, impairing recovery and daytime functioning. Even caffeine consumed hours before bedtime affects sleep quality. Limiting afternoon and evening intake is important to maintain healthy sleep. Further research is needed on individual sensitivity and long-term effects.

References

Rasch, B., & Born, J. (2013). About Sleep's Role in Memory. Physiological Reviews, 93(2), 681–766. https://doi.org/10.1152/physrev.00032.2012

Dijk, D. J., & Landolt, H. P. (2019). Sleep Physiology, Circadian Rhythms, Waking Performance and the Development of Sleep-Wake Therapeutics. Handbook of experimental pharmacology, 253, 441–481. https://doi.org/10.1007/164_2019_243

Reichert, C. F., Veitz, S., Bühler, M., Gruber, G., Deuring, G., Rehm, S. S., Rentsch, K., Garbazza, C., Meyer, M., Slawik, H., Lin, Y. S., & Weibel, J. (2021). Wide awake at bedtime? Effects of caffeine on sleep and circadian timing in male adolescents - A randomized crossover trial. Biochemical pharmacology, 191, 114283. https://doi.org/10.1016/j.bcp.2020.114283

Chennaoui, M., Vanneau, T., Trignol, A., Arnal, P., Gomez-Merino, D., Baudot, C., Perez, J., Pochettino, S., Eirale, C., & Chalabi, H. (2021). How does sleep help recovery from exercise-induced muscle injuries?. Journal of science and medicine in sport, 24(10), 982–987. https://doi.org/10.1016/j.jsams.2021.05.007

Brodt, S., Inostroza, M., Niethard, N., & Born, J. (2023). Sleep-A brain-state serving systems memory consolidation. Neuron, 111(7), 1050–1075. https://doi.org/10.1016/j.neuron.2023.03.005

Palmer, C. A., & Alfano, C. A. (2017). Sleep and emotion regulation: An organizing, integrative review. Sleep medicine reviews, 31, 6–16. https://doi.org/10.1016/j.smrv.2015.12.006

Fuller, P. M., Gooley, J. J., & Saper, C. B. (2006). Neurobiology of the sleep-wake cycle: sleep architecture, circadian regulation, and regulatory feedback. Journal of biological rhythms, 21(6), 482–493. https://doi.org/10.1177/0748730406294627

Heckman, M. A., Weil, J., & Gonzalez de Mejia, E. (2010). Caffeine (1, 3, 7-trimethylxanthine) in foods: a comprehensive review on consumption, functionality, safety, and regulatory matters. Journal of food science, 75(3), R77–R87. https://doi.org/10.1111/j.1750-3841.2010.01561.x

Barone, J. J., & Roberts, H. R. (1996). Caffeine consumption. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 34(1), 119–129. https://doi.org/10.1016/0278-6915(95)00093-3

Orbeta, R. L., Overpeck, M. D., Ramcharran, D., Kogan, M. D., & Ledsky, R. (2006). High caffeine intake in adolescents: associations with difficulty sleeping and feeling tired in the morning. The Journal of adolescent health : official publication of the Society for Adolescent Medicine, 38(4), 451–453. https://doi.org/10.1016/j.jadohealth.2005.05.014

Wendte, R., Snel, J., & Tieges, Z. (2003). Misclassification of caffeine use: Causes and examples. In Fac. Psychologie, Programmagroep Psychonomie (pp. 1–20). Amsterdam: Universiteit van Amsterdam.

Calhoun L. K. (1996). Pharmacologic management of apnea of prematurity. The Journal of perinatal & neonatal nursing, 9(4), 56–62. https://doi.org/10.1097/00005237-199603000-00007

Nehlig, A., Daval, J. L., & Debry, G. (1992). Caffeine and the central nervous system: mechanisms of action, biochemical, metabolic and psychostimulant effects. Brain research. Brain research reviews, 17(2), 139–170. https://doi.org/10.1016/0165-0173(92)90012-b

Kamimori, G. H., Karyekar, C. S., Otterstetter, R., Cox, D. S., Balkin, T. J., Belenky, G. L., & Eddington, N. D. (2002). The rate of absorption and relative bioavailability of caffeine administered in chewing gum versus capsules to normal healthy volunteers. International journal of pharmaceutics, 234(1-2), 159–167. https://doi.org/10.1016/s0378-5173(01)00958-9

Ribeiro, J. A., & Sebastião, A. M. (2010). Caffeine and adenosine. Journal of Alzheimer's disease : JAD, 20 Suppl 1, S3–S15. https://doi.org/10.3233/JAD-2010-1379

Lorist, M. M., & Tops, M. (2003). Caffeine, fatigue, and cognition. Brain and cognition, 53(1), 82–94. https://doi.org/10.1016/s0278-2626(03)00206-9

Landolt H. P. (2008). Sleep homeostasis: a role for adenosine in humans?. Biochemical pharmacology, 75(11), 2070–2079. https://doi.org/10.1016/j.bcp.2008.02.024

Drake, C., Roehrs, T., Shambroom, J., & Roth, T. (2013). Caffeine effects on sleep taken 0, 3, or 6 hours before going to bed. Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 9(11), 1195–1200. https://doi.org/10.5664/jcsm.3170

Belenky, G., Wesensten, N. J., Thorne, D. R., Thomas, M. L., Sing, H. C., Redmond, D. P., Russo, M. B., & Balkin, T. J. (2003). Patterns of performance degradation and restoration during sleep restriction and subsequent recovery: a sleep dose-response study. Journal of sleep research, 12(1), 1–12. https://doi.org/10.1046/j.1365-2869.2003.00337.x

Drake, C. L., Roehrs, T. A., Burduvali, E., Bonahoom, A., Rosekind, M., & Roth, T. (2001). Effects of rapid versus slow accumulation of eight hours of sleep loss. Psychophysiology, 38(6), 979–987. https://doi.org/10.1111/1469-8986.3860979

Van Dongen, H. P. A., Maislin, G., Mullington, J. M., & Dinges, D. F. (2003). The Cumulative Cost of Additional Wakefulness: Dose-Response Effects on Neurobehavioral Functions and Sleep Physiology From Chronic Sleep Restriction and Total Sleep Deprivation. Sleep, 26(2), 117–126. https://doi.org/10.1093/sleep/26.2.117

Levine, B., Roehrs, T., Stepanski, E., Zorick, F., & Roth, T. (1987). Fragmenting sleep diminishes its recuperative value. Sleep, 10(6), 590–599.

Roehrs, T., & Roth, T. (2008). Caffeine: sleep and daytime sleepiness. Sleep medicine reviews, 12(2), 153–162. https://doi.org/10.1016/j.smrv.2007.07.004

Drapeau, C., Hamel-Hébert, I., Robillard, R., Selmaoui, B., Filipini, D., & Carrier, J. (2006). Challenging sleep in aging: the effects of 200 mg of caffeine during the evening in young and middle-aged moderate caffeine consumers. Journal of sleep research, 15(2), 133–141. https://doi.org/10.1111/j.1365-2869.2006.00518.x

Zwyghuizen-Doorenbos, A., Roehrs, T. A., Lipschutz, L., Timms, V., & Roth, T. (1990). Effects of caffeine on alertness. Psychopharmacology, 100(1), 36–39. https://doi.org/10.1007/BF02245786

Howland, J., & Rohsenow, D. J. (2013). Risks of energy drinks mixed with alcohol. JAMA, 309(3), 245–246. https://doi.org/10.1001/jama.2012.187978

Sepkowitz K. A. (2013). Energy drinks and caffeine-related adverse effects. JAMA, 309(3), 243–244. https://doi.org/10.1001/jama.2012.173526

Weibel, J., Lin, Y. S., Landolt, H. P., Berthomier, C., Brandewinder, M., Kistler, J., Rehm, S., Rentsch, K. M., Meyer, M., Borgwardt, S., Cajochen, C., & Reichert, C. F. (2021). Regular Caffeine Intake Delays REM Sleep Promotion and Attenuates Sleep Quality in Healthy Men. Journal of biological rhythms, 36(4), 384–394. https://doi.org/10.1177/07487304211013995

Pauchon, B., Beauchamps, V., Gomez-Mérino, D., Erblang, M., Drogou, C., Beers, P. V., Guillard, M., Quiquempoix, M., Léger, D., Chennaoui, M., & Sauvet, F. (2024). Caffeine Intake Alters Recovery Sleep after Sleep Deprivation. Nutrients, 16(20), 3442. https://doi.org/10.3390/nu16203442

Pecotić, R., Valić, M., Kardum, G., Sevo, V., & Dogas, Z. (2008). Navike spavanja studenata medicine, lijecnika i medicinskih sestara--utjecaj dobi, spola, noćnog rada i konzumacije kofeina [Sleep habits of medical students, physicians and nurses regarding age, sex, shift work and caffein consumption]. Lijecnicki vjesnik, 130(3-4), 87–91.

Bonnet, M. H., & Arand, D. L. (1992). Caffeine use as a model of acute and chronic insomnia. Sleep, 15(6), 526–536.

Karacan, I., Thornby, J. I., Anch, M., Booth, G. H., Williams, R. L., & Salis, P. J. (1976). Dose-related sleep disturbances induced by coffee and caffeine. Clinical pharmacology and therapeutics, 20(6), 682–689. https://doi.org/10.1002/cpt1976206682

Lasagna L. (1977). Dose-related sleep disturbances induced by coffee and caffeine. Clinical pharmacology and therapeutics, 21(2), 244. https://doi.org/10.1002/cpt1977212244

Yanik, G., Glaum, S., & Radulovacki, M. (1987). The dose-response effects of caffeine on sleep in rats. Brain research, 403(1), 177–180. https://doi.org/10.1016/0006-8993(87)90141-7

Bonnet, M., Tancer, M., Uhde, T., & Yeragani, V. K. (2005). Effects of caffeine on heart rate and QT variability during sleep. Depression and anxiety, 22(3), 150–155. https://doi.org/10.1002/da.20127

Landolt, H. P., Werth, E., Borbély, A. A., & Dijk, D. J. (1995). Caffeine intake (200 mg) in the morning affects human sleep and EEG power spectra at night. Brain research, 675(1-2), 67–74. https://doi.org/10.1016/0006-8993(95)00040-w

Mahoney, C. R., Giles, G. E., Marriott, B. P., Judelson, D. A., Glickman, E. L., Geiselman, P. J., & Lieberman, H. R. (2019). Intake of caffeine from all sources and reasons for use by college students. Clinical nutrition (Edinburgh, Scotland), 38(2), 668–675. https://doi.org/10.1016/j.clnu.2018.04.004

Clark, I., & Landolt, H. P. (2017). Coffee, caffeine, and sleep: A systematic review of epidemiological studies and randomized controlled trials. Sleep medicine reviews, 31, 70–78. https://doi.org/10.1016/j.smrv.2016.01.006

Carrier, J., Fernandez-Bolanos, M., Robillard, R., Dumont, M., Paquet, J., Selmaoui, B., & Filipini, D. (2006). Effects of Caffeine are more Marked on Daytime Recovery Sleep than on Nocturnal Sleep. Neuropsychopharmacology, 32(4), 964–972. https://doi.org/10.1038/sj.npp.1301198

Carrier, J., Paquet, J., Fernandez-Bolanos, M., Girouard, L., Roy, J., Selmaoui, B., & Filipini, D. (2009). Effects of caffeine on daytime recovery sleep: A double challenge to the sleep-wake cycle in aging. Sleep medicine, 10(9), 1016–1024. https://doi.org/10.1016/j.sleep.2009.01.001

Robillard, R., Bouchard, M., Cartier, A., Nicolau, L., & Carrier, J. (2015). Sleep is more sensitive to high doses of caffeine in the middle years of life. Journal of psychopharmacology (Oxford, England), 29(6), 688–697. https://doi.org/10.1177/0269881115575535

James J. E. (1998). Acute and chronic effects of caffeine on performance, mood, headache, and sleep. Neuropsychobiology, 38(1), 32–41. https://doi.org/10.1159/000026514

Weibel, J., Lin, Y. S., Landolt, H. P., Garbazza, C., Kolodyazhniy, V., Kistler, J., Rehm, S., Rentsch, K., Borgwardt, S., Cajochen, C., & Reichert, C. F. (2020). Caffeine-dependent changes of sleep-wake regulation: Evidence for adaptation after repeated intake. Progress in neuro-psychopharmacology & biological psychiatry, 99, 109851. https://doi.org/10.1016/j.pnpbp.2019.109851

Goel, N., Rao, H., Durmer, J. S., & Dinges, D. F. (2009). Neurocognitive consequences of sleep deprivation. Seminars in neurology, 29(4), 320–339. https://doi.org/10.1055/s-0029-1237117

Views:

37

Downloads:

19

Published
2025-09-30
Citations
How to Cite
Żaneta Kania, Remigiusz Flakus, Julia Szczotka, Gabriela Szpila, Weronika Perczyńska, Gabriela Kapłon, Dominika Gieroba, Anna Kamieniak, Artur Tumiński, Marianna Chmiel, Aleksandra Sokół, & Karolina Glajcar. (2025). UNDERSTANDING THE RELATIONSHIP BETWEEN CAFFEINE AND SLEEP - A REVIEW. International Journal of Innovative Technologies in Social Science, 5(3(47). https://doi.org/10.31435/ijitss.3(47).2025.3882

Most read articles by the same author(s)