THE IMPACT OF GUT MICROBIOTA ON THE PATHOPHYSIOLOGY AND MANIFESTATION OF ADHD
Abstract
Attention Deficit Hyperactivity Disorder (ADHD) is currently being thoroughly investigated by the global medical community, resulting in a deeper comprehension of the disorder. The relationship between the intestine microbiome and the human body could be a noteworthy center of advanced inquire about, especially with respect to the gut-brain association. The intestine microbiome influences metabolic, immune, and neurological forms, sending signals to the brain through different immune and neurochemical pathways. Within the past, neuropsychiatric conditions were regularly credited exclusively to modifications within the brain, ignoring the affect of the resistant and metabolic frameworks. Later studies indicate that the microbiome can influence brain functioning by creating neuroactive compounds, which can in this way impact behavior and cognitive capacities. In this setting, there's an expanding interest approximately the part the intestine microbiome plays in neurodevelopmental conditions like ADHD.
Aim of the study: The purpose of this paper is to elucidate the current state of knowledge regarding the correlation between gut microbiota and Attention Deficit Hyperactivity Disorder. It examines the pathways via which bacteria may influence the functioning of the gut-brain axis and the development and severity of symptoms of the disorder. It also delineates the most recent findings concerning the potential therapeutic modulation of gut microbiota composition as a complement to conventional ADHD treatment.
Materials and methods: A review of the literature available in the PubMed and Google Scholar database was performed, using the key words: “gut microbiome”, “gut-brain axis”, “Attention Deficit Hyperactivity Disorder”, “ADHD”, “prebiotics”, “probiotics”, “synbiotics”, “short-chain fatty acids”.
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