ACUTE APPENDICITIS IN PREGNANCY – DIAGNOSTIC AND THERAPEUTIC CHALLENGES

Keywords: Appendicitis, Pregnancy, Diagnosis, Treatment

Abstract

Background: Acute appendicitis during pregnancy is one of the most common non-obstetric surgical conditions in pregnant women. However, due to the ambiguous symptoms that may be presented, an accurate diagnosis can be delayed or misinterpreted as a result of pregnancy-related changes.

Aim: The aim of this article is to highlight the challenges involved in diagnosing and treating acute appendicitis in pregnant women.

Methods: A review of scientific articles published on Google Scholar and PubMed from 2015 to 2025.

Results: Acute appendicitis in pregnancy presents with identical symptoms or mimics several other diseases, not only obstetric conditions. Surgical treatment is recommended, but there are no clear guidelines favoring either laparoscopic or open methods. Magnetic resonance imaging (MRI) is the most accurate imaging modality for diagnosing acute appendicitis. Laboratory diagnostics do not provide definitive evidence for appendicitis in pregnancy.

Conclusion: It is essential to be aware of the numerous ways acute appendicitis can present in pregnancy and to remain critical of an initially proposed diagnosis. The choice of surgical treatment largely depends on the experience and skill of the physician. Therefore, continuous education is necessary to understand the challenges associated with this condition.

References

Konturek, A. (2024, July 15). Ostre zapalenie wyrostka robaczkowego. Interna – Mały Podręcznik. Medycyna Praktyczna. Retrieved August 22, 2025, from https://www.mp.pl/interna/chapter/B16.II.4.25.3

Téoule P, Laffolie J, Rolle U, Reissfelder C. Acute Appendicitis in Childhood and Adulthood. Dtsch Arztebl Int. 2020 Nov 6;117(45):764-774. https://doi.org/10.3238/arztebl.2020.0764. PMID: 33533331; PMCID: PMC7898047.

Haataja, A., Kokki, H., Uimari, O., & Kokki, M. (2023). Non-obstetric surgery during pregnancy and the effects on maternal and fetal outcomes: A systematic review. Scandinavian journal of surgery : SJS : official organ for the Finnish Surgical Society and the Scandinavian Surgical Society, 112(3), 187–205. https://doi.org/10.1177/14574969231175569

Lotfollahzadeh, S., Lopez, R. A., Deppen, J. G., & Kendall, B. A. (2024). Appendicitis (Nursing). In StatPearls. StatPearls Publishing.

Zingone, F., Sultan, A. A., Humes, D. J., & West, J. (2015). Risk of acute appendicitis in and around pregnancy: a population-based cohort study from England. Annals of surgery, 261(2), 332–337. https://doi.org/10.1097/SLA.0000000000000780

Feng, Y., Miao, C., & Zhao, Y. (2023). Predicting Acute Appendicitis in Pregnant Patients Using the Neutrophil-to-Lymphocyte Ratio: A Meta-Analysis. Surgical infections, 24(10), 903–909. https://doi.org/10.1089/sur.2023.269

Liu, L., Shao, Z., Yu, H., Zhang, W., Wang, H., & Mei, Z. (2020). Is the platelet to lymphocyte ratio a promising biomarker to distinguish acute appendicitis? Evidence from a systematic review with meta-analysis. PloS one, 15(5), e0233470. https://doi.org/10.1371/journal.pone.0233470

Moghadam, M. N., Salarzaei, M., & Shahraki, Z. (2022). Diagnostic accuracy of ultrasound in diagnosing acute appendicitis in pregnancy: a systematic review and meta-analysis. Emergency radiology, 29(3), 437–448. https://doi.org/10.1007/s10140-022-02021-9

Wang, Z., Bao, F., Liang, W., Wu, H., Lin, Z., Xu, J., & Dong, F. (2023). Appendicitis in pregnant women: A systematic review and meta-analysis of the diagnostic performance of ultrasonography. Journal of clinical ultrasound : JCU, 51(9), 1492–1501. https://doi.org/10.1002/jcu.23566

Shen, G., Wang, J., Fei, F., Mao, M., & Mei, Z. (2019). Bedside ultrasonography for acute appendicitis: An updated diagnostic meta-analysis. International journal of surgery (London, England), 70, 1–9. https://doi.org/10.1016/j.ijsu.2019.08.009

Cho, S. U., & Oh, S. K. (2021). Diagnostic accuracy of magnetic resonance imaging for acute appendicitis during pregnancy: A systematic review. Gebelikte akut apandisit için manyetik rezonans görüntülemenin tanısal doğruluğu: Sistematik bir inceleme. Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES, 27(3), 271–277. https://doi.org/10.14744/tjtes.2020.02416

Kave, M., Parooie, F., & Salarzaei, M. (2019). Pregnancy and appendicitis: a systematic review and meta-analysis on the clinical use of MRI in diagnosis of appendicitis in pregnant women. World journal of emergency surgery : WJES, 14, 37. https://doi.org/10.1186/s13017-019-0254-1

D'Souza, N., Hicks, G., Beable, R., Higginson, A., & Rud, B. (2021). Magnetic resonance imaging (MRI) for diagnosis of acute appendicitis. The Cochrane database of systematic reviews, 12(12), CD012028. https://doi.org/10.1002/14651858.CD012028.pub2

Candrawinata, V., Hanafi, R., Baskoro, B. A., Irawan, A., Ekapatria, C., Christina, N. M., Koerniawan, H. S., & Halim, F. (2023). Antibiotic versus surgery in the treatment of acute appendicitis in the pregnant population: A systematic review and meta-analysis. F1000Research, 12, 188. https://doi.org/10.12688/f1000research.129906.2

Zou, T., & Yao, Q. (2024). Safety of appendectomy during pregnancy: An umbrella review based on existing meta-analyses. Asian journal of surgery, 47(4), 2083–2085. https://doi.org/10.1016/j.asjsur.2024.01.009

Prodromidou, A., Machairas, N., Kostakis, I. D., Molmenti, E., Spartalis, E., Kakkos, A., Lainas, G. T., & Sotiropoulos, G. C. (2018). Outcomes after open and laparoscopic appendectomy during pregnancy: A meta-analysis. European journal of obstetrics, gynecology, and reproductive biology, 225, 40–50. https://doi.org/10.1016/j.ejogrb.2018.04.010

Chakraborty, J., Kong, J. C., Su, W. K., Gourlas, P., Gillespie, C., Slack, T., Morris, B., & Lutton, N. (2019). Safety of laparoscopic appendicectomy during pregnancy: a systematic review and meta-analysis. ANZ journal of surgery, 89(11), 1373–1378. https://doi.org/10.1111/ans.14963

Frountzas, M., Nikolaou, C., Stergios, K., Kontzoglou, K., Toutouzas, K., & Pergialiotis, V. (2019). Is the laparoscopic approach a safe choice for the management of acute appendicitis in pregnant women? A meta-analysis of observational studies. Annals of the Royal College of Surgeons of England, 101(4), 235–248. https://doi.org/10.1308/rcsann.2019.0011

Liew, A. N., Lim, K. Y., Quach, D., Tsui, L. W., Croagh, D., & Ackermann, T. G. (2022). Laparoscopic versus open appendicectomy in pregnancy: experience from a single institution and meta-analysis. ANZ journal of surgery, 92(5), 1071–1078. https://doi.org/10.1111/ans.17672

Lee, S. H., Lee, J. Y., Choi, Y. Y., & Lee, J. G. (2019). Laparoscopic appendectomy versus open appendectomy for suspected appendicitis during pregnancy: a systematic review and updated meta-analysis. BMC surgery, 19(1), 41. https://doi.org/10.1186/s12893-019-0505-9

Zapletal, J., Sehnal, B., Drochytek, V., Hruda, M., Lochmanova, I., Halaska, M. J., & Oliverius, M. (2025). Appendicitis in Pregnancy: A Multidisciplinary Approach and Optimal Management from the Perspective of Gynecology and Obstetrics - A Case Report. Visceral medicine, 41(2), 86–91. https://doi.org/10.1159/000543297

Adamina, M., Andreou, A., Arezzo, A., Christogiannis, C., Di Lorenzo, N., Gioumidou, M., Glavind, J., Iavazzo, C., Mavridis, D., Muysoms, F. E., Preda, D., Smart, N. J., Syropoulou, A., Tzanis, A. Α., Van de Velde, M., Vermeulen, J., & Antoniou, S. A. (2022). EAES rapid guideline: systematic review, meta-analysis, GRADE assessment, and evidence-informed European recommendations on appendicitis in pregnancy. Surgical endoscopy, 36(12), 8699–8712. https://doi.org/10.1007/s00464-022-09625-9

Kumar, S. S., Collings, A. T., Wunker, C., Athanasiadis, D. I., DeLong, C. G., Hong, J. S., Ansari, M. T., Abou-Setta, A., Oliver, E., Berghella, V., Alli, V., Hassan, I., Hollands, C., Sylla, P., Slater, B. J., & Palazzo, F. (2024). SAGES guidelines for the use of laparoscopy during pregnancy. Surgical endoscopy, 38(6), 2947–2963. https://doi.org/10.1007/s00464-024-10810-1

Carstens, A. K., Fensby, L., & Penninga, L. (2018). Nonoperative Treatment of Appendicitis during Pregnancy in a Remote Area. AJP reports, 8(1), e37–e38. https://doi.org/10.1055/s-0037-1620279

Tavakoli, A., Wadensweiler, P., Blumenthal, E., Kuncir, E., Houshyar, R., & Brueseke, T. (2020). Medical management of appendicitis in early-term pregnancy. BMJ case reports, 13(8), e234252. https://doi.org/10.1136/bcr-2020-234252

Kazma, J. M., van den Anker, J., Allegaert, K., Dallmann, A., & Ahmadzia, H. K. (2020). Anatomical and physiological alterations of pregnancy. Journal of pharmacokinetics and pharmacodynamics, 47(4), 271–285. https://doi.org/10.1007/s10928-020-09677-1

Kyhl, L. K., & Løkkegaard, E. K. L. (2021). Ugeskrift for laeger, 183(17), V10200789.

Kim, Y., & Hwang, I. (2021). Acute appendicitis in pregnancy mimicking leiomyoma pain. BMJ case reports, 14(5), e238476. https://doi.org/10.1136/bcr-2020-238476

Dao, D., Abdel-Raheem, M., & Lazim, T. R. (2023). A Spontaneous Heterotopic Pregnancy Presenting as Acute Appendicitis. Cureus, 15(8), e42803. https://doi.org/10.7759/cureus.42803

Mamah, J., Thomas, M., & Rafi, J. (2023). Spontaneous Hemoperitoneum in Pregnancy: Masquerading as Acute Appendicitis. Cureus, 15(10), e47040. https://doi.org/10.7759/cureus.47040

Sanders-Davis, L. J., & Ritchie, J. (2021). Appendicitis with concurrent COVID-19 infection in a patient during the third trimester of pregnancy. BMJ case reports, 14(6), e242651. https://doi.org/10.1136/bcr-2021-242651

Kiyose, M., Shiro, M., Inagaki, M., Watanabe, T., & Maeda, T. (2025). Perforated Appendicitis With Deciduosis and Free Air Under the Diaphragm During Pregnancy. Cureus, 17(5), e83758. https://doi.org/10.7759/cureus.83758

Saleh, M., Kim, A. F., Gardner, A., Sun, K., & Brubaker, S. (2020). Peritoneovaginal Fistula and Appendicitis-Related Pelvic Abscess in Pregnancy. AJP reports, 10(2), e129–e132. https://doi.org/10.1055/s-0040-1708849

Green, J., & Biglione, A. (2024). Fibroid Degeneration During Pregnancy Presenting as Appendicitis. Cureus, 16(4), e57660. https://doi.org/10.7759/cureus.57660

Nwashilli, N. J., Okonta, P., & Faleyimu, B. (2024). Leaking Ectopic Pregnancy Following In vitro Fertilization with Associated Acute Appendicitis. West African journal of medicine, 41(4), 485–488.

Yang, W., Jones, A., Mahil, A., & Nahrwold, D. (2024). Management of gastrointestinal stromal tumor and acute appendicitis during pregnancy: A case report. Case reports in women's health, 43, e00635. https://doi.org/10.1016/j.crwh.2024.e00635

Chung, J., & Berryman, R. P. (2020). An Atypical Case of a Common Pregnancy Issue: Appendicitis-Like Hyperemesis Gravidarum. Case reports in medicine, 2020, 6959605. https://doi.org/10.1155/2020/6959605

Aroke, D., Kadia, B. M., Dimala, C. A., Bechem, N. N., Ngek, L. T., & Choukem, S. P. (2017). Right iliac vein thrombosis mimicking acute appendicitis in pregnancy: a case report. BMC research notes, 10(1), 11. https://doi.org/10.1186/s13104-016-2351-5

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Published
2025-09-25
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How to Cite
Jan Palmi, Elżbieta Bebrysz, Karolina Dębek-Kalinowska, Piotr Bartnik, Jarosław Baran, Ida Dunder, Magdalena Koss, Mateusz Biszewski, Aleksandra Drabik, & Weronika Ziomek. (2025). ACUTE APPENDICITIS IN PREGNANCY – DIAGNOSTIC AND THERAPEUTIC CHALLENGES. International Journal of Innovative Technologies in Social Science, 4(3(47). https://doi.org/10.31435/ijitss.3(47).2025.3695

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