FAILURE TO THRIVE (FTT) IN INFANTS: AN EVIDENCE-BASED REVIEW OF CAUSES AND MANAGEMENT
Abstract
Failure to thrive (FTT) in infancy is a multifactorial condition characterized by inadequate physical growth due to medical, nutritional, or psychosocial factors. This review explores the underlying causes and evidence-based strategies for diagnosis and management of FTT in infants. Drawing from clinical guidelines and recent studies, the article emphasizes the need for accurate anthropometric assessment using standardized growth charts and z-scores. FTT is commonly classified as either organic, linked to identifiable medical conditions, or non-organic, often associated with environmental stressors or inadequate caregiving practices. Comprehensive clinical evaluation, including detailed history-taking, physical examination, and recognition of red-flag symptoms, is essential for early detection. Management requires individualized nutritional rehabilitation, treatment of underlying medical issues, and psychosocial support involving multidisciplinary teams. Early, targeted intervention is associated with improved outcomes in growth, cognition, and emotional development. Standardized diagnostic criteria, coordinated care plans, and caregiver support are critical for mitigating the long-term consequences of growth faltering and optimizing developmental trajectories in this vulnerable population.
References
Olsen EM. Failure to thrive: still a problem of definition. Clin Pediatr (Phila). 2006;45(1):1-6.
Wright CM, Macleod K, Vincent S, et al. Failure to thrive in the UK: a population-based cohort study. Arch Dis Child. 2010;95(4):290-294.
de Onis M, Onyango AW, Borghi E, et al. WHO Child Growth Standards. Acta Paediatr Suppl. 2006;450:76-85.
Black MM, Dewey KG. Promoting equity through integrated early child development and nutrition interventions. Ann N Y Acad Sci. 2014;1308(1):1-10.
Cole SZ, Lanham JS. Failure to thrive: an update. Am Fam Physician. 2011;83(7):829-834.
Emond A, Drewett R, Blair P, et al. Postnatal factors associated with failure to thrive in term infants in the Avon Longitudinal Study of Parents and Children. Arch Dis Child. 2007;92(2):115-119.
Grantham-McGregor S, Cheung YB, Cueto S, et al. Developmental potential in the first 5 years for children in developing countries. Lancet. 2007;369(9555):60-70.
Victora CG, Adair L, Fall C, et al. Maternal and child undernutrition: consequences for adult health and human capital. Lancet. 2008;371(9609):340-357.
Savage MO. Growth hormone deficiency: diagnosis and current management. Arch Dis Child. 2010;95(6):476-482.
Becker P, Carney LN, Corkins MR, et al. Consensus statement of the Academy of Nutrition and Dietetics/American Society for Parenteral and Enteral Nutrition: indicators for identifying children at nutritional risk. Nutr Clin Pract. 2015;30(1):147-161.
Leroy JL, Frongillo EA Jr. Perspective: what does stunting really mean? A critical review of the evidence. Adv Nutr. 2019;10(2):196-204.
Holcombe E, Benton T, Hurtado N, et al. Psychosocial factors influencing failure to thrive: a systematic review. J Pediatr Health Care. 2017;31(1):21-28.
Callahan CW, Brannon WM, Hall CA, et al. Poor feeding skills in infants with failure to thrive. Pediatrics. 2001;107(3):e40.
Sullivan PB, Juszczak E, Bachlet AM, et al. Feeding difficulties in disabled children. Dev Med Child Neurol. 2000;42(10):724-728.
Dewey KG, Begum K. Long-term consequences of stunting in early life. Matern Child Nutr. 2011;7 Suppl 3:5-18.
Victora CG, Adair L, Fall C, et al. Maternal and child undernutrition: consequences for adult health and human capital. Lancet. 2008;371(9609):340-357.
Grummer-Strawn LM, Reinold C, Krebs NF. Use of World Health Organization and CDC growth charts for children aged 0–59 months in the United States. MMWR Recomm Rep. 2010;59(RR-9):1-15.
Sandler AD. Failure to thrive: an update. Pediatr Rev. 2009;30(8):313-321.
Kerzner B, Milano K, MacLean WC Jr, et al. A practical approach to classifying and managing feeding difficulties in infants and young children. Pediatrics. 2015;135(2):344-353.
Brown KH, Peerson JM, Rivera J, Allen LH. Effect of supplemental zinc on the growth and serum zinc concentrations of prepubertal children: a meta-analysis of randomized controlled trials. Am J Clin Nutr. 2002;75(6):1062-1071.
Korada SK, Russell RK. Failure to thrive: evaluation and management. Pediatr Rev. 2010;31(7):e32-e39.
Baird J, Fisher D, Lucas P, et al. Being big or growing fast: systematic review of size and growth in infancy and later obesity. BMJ. 2005;331(7522):929.
Shaker CS, Lenderking WR, Barone M. Psychosocial factors affecting feeding and growth failure in infants and toddlers. J Dev Behav Pediatr. 1988;9(5):306-312.
Thomson WM, Wadsworth ME, Brook TG, et al. Effect of maternal depression on failure to thrive in early childhood. Arch Dis Child. 2002;86(2):98-102.
Black MM. Effects of vitamin B12 and folate deficiency on brain development in children. Food Nutr Bull. 2008;29(2 Suppl):S126-S131.
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