IMPACT OF ENDURANCE SPORTS ON IRON LEVELS AND ANEMIA RISK IN FEMALE ATHLETES: A REVIEW

Keywords: Iron Deficiencies, Athletes, Endurance Training; Menstrual Cycle, Dietary Supplements

Abstract

Iron plays a crucial role in oxygen transport and energy metabolism, making it essential for athletic performance. Female endurance athletes are particularly susceptible to iron deficiency due to high training loads, menstrual blood loss, restrictive diets, and inflammation-induced hepcidin elevations. This review examines the prevalence, physiological mechanisms, and key causes of iron deficiency in female athletes. Evidence shows that iron losses occur through sweat, hemolysis, gastrointestinal bleeding, and exercise-induced inflammation. Heavy menstrual bleeding and relative energy deficiency in sport (RED-S) further increase risk. Additionally, genetic factors such as ACTN3 and HFE mutations may influence iron metabolism in athletes. Iron deficiency, even in the absence of anemia, is linked to impaired aerobic capacity, reduced endurance, and fatigue. Effective prevention and management strategies include regular monitoring, tailored dietary interventions, and iron supplementation when needed. Awareness of iron status is vital for female endurance athletes to sustain both health and performance.

References

Sims ST, Mackay K, Leabeater A, Clarke A, Schofield K, Driller M. High Prevalence of Iron Deficiency Exhibited in Internationally Competitive, Non-Professional Female Endurance Athletes-A Case Study. Int J Environ Res Public Health. 2022 Dec 10;19(24):16606. doi: 10.3390/ijerph192416606. PMID: 36554486; PMCID: PMC9778947.

Dunn, L.D., Callahan, C. & Rogers, M. et al. (2024). Prevalence of Iron Deficiency in Female Collegiate Athletes at a Division I Institution. J Womens Sports Med, 4(2), 9–18.

Tabata S, Tsukahara Y, Kamada H, Manabe T, Yamasawa F. Prevalence of anemia and iron deficiency and its association with body mass index in elite Japanese high school long-distance runners. Phys Sportsmed. 2024 Aug;52(4):360-368. doi: 10.1080/00913847.2023.2267561. Epub 2023 Oct 9. PMID: 37795704.

DiSilvestro RA, Joseph E, Diehl J, Swain CB. Ferritin readings in young adult, female university student recreational runners. J Trace Elem Med Biol. 2020 Dec;62:126617. doi: 10.1016/j.jtemb.2020.126617. Epub 2020 Jul 8. PMID: 32653832.

Coates, Alexandra BSc*; Mountjoy, Margo MD, PhD†,‡,§; Burr, Jamie PhD*. Incidence of Iron Deficiency and Iron Deficient Anemia in Elite Runners and Triathletes. Clinical Journal of Sport Medicine 27(5):p 493-498, September 2017. | DOI: 10.1097/JSM.0000000000000390

McCormick R, Dawson B, Sim M, Lester L, Goodman C, Peeling P. The Effectiveness of Transdermal Iron Patches in Athletes With Suboptimal Iron Status (Part 1). Int J Sport Nutr Exerc Metab. 2020 May 1;30(3):185–190. doi: 10.1123/ijsnem.2019-0309. Epub 2020 Mar 27. PMID: 32217791.

McCormick R, Dreyer A, Dawson B, Sim M, Lester L, Goodman C, Peeling P. The Effectiveness of Daily and Alternate Day Oral Iron Supplementation in Athletes With Suboptimal Iron Status (Part 2). Int J Sport Nutr Exerc Metab. 2020 May 1;30(3):191–196. doi: 10.1123/ijsnem.2019-0310. Epub 2020 Mar 27. PMID: 32217790.

Burden RJ, Pollock N, Whyte GP, Richards T, Moore B, Busbridge M, Srai SK, Otto J, Pedlar CR. Effect of Intravenous Iron on Aerobic Capacity and Iron Metabolism in Elite Athletes. Med Sci Sports Exerc. 2015 Jul;47(7):1399-407. doi: 10.1249/MSS.0000000000000568. PMID: 25386711.

Dugan C, Peeling P, Buissink P, MacLean B, Lim J, Jayasuriya P, Richards T. Effect of intravenous iron therapy on exercise performance, fatigue scores and mood states in iron-deficient recreationally active females of reproductive age: a double-blind, randomised control trial (IRONWOMAN Trial). Br J Sports Med. 2025 Mar 3:bjsports-2024-108240. doi: 10.1136/bjsports-2024-108240. Epub ahead of print. PMID: 40032294.

Pengelly M, Pumpa K, Pyne DB, Etxebarria N. Iron deficiency, supplementation, and sports performance in female athletes: A systematic review. J Sport Health Sci. 2024 Nov 12;14:101009. doi: 10.1016/j.jshs.2024.101009. Epub ahead of print. PMID: 39536912; PMCID: PMC11863318.

Damian MT, Vulturar R, Login CC, Damian L, Chis A, Bojan A. Anemia in Sports: A Narrative Review. Life (Basel). 2021 Sep 20;11(9):987. doi: 10.3390/life11090987. PMID: 34575136; PMCID: PMC8472039.

Clénin G., Cordes M., Huber A., Schumacher Y.O., Noack P., Scales J., Kriemler S. Iron deficiency in sports—Definition, influence on performance and therapy. Schweiz. Z. Fur. Sport Und Sport. 2016;64:6–18. doi: 10.4414/smw.2015.14196

Sim, M., Garvican-Lewis, L.A., Cox, G.R. et al. (2024). Iron Deficiency, Supplementation and Sports Performance in Female Athletes. Asia Pac J Sports Med Arthrosc Rehabil Technol, 29, 1–9.

Varamenti E., Nikolovski Z., Elgingo M.I., Jamurtas A.Z., Cardinale M. Training-Induced Variations in Haematological and Biochemical Variables in Adolescent Athletes of Arab Origin Throughout an Entire Athletic Season. J. Hum. Kinet. 2018;64:123–135. doi: 10.1515/hukin-2017-0187.

Kong W.N., Gao G., Chang Y.Z. Hepcidin and sports anemia. Cell Biosci. 2014;4:1–11. doi: 10.1186/2045-3701-4-19.

Larsuphrom P., Latunde-Dada G.O. Association of serum hepcidin levels with aerobic and resistance exercise: A systematic review. Nutrients. 2021;13:393. doi: 10.3390/nu13020393.

Van Hasselt P.M., Clayton P.H.R. Disorders in the Transport of Copper, Iron, Magnesium. In: Saudubray J.M., Baumgartner M.R., editors. Inborn Metabolic Diseases. 6th ed. Springer; Berlin/Heidelberg, Germany: 2016. pp. 531–548.

Kowdley K.V., Brown K.E., Ahn J., Sundaram V. ACG Clinical Guideline: Hereditary Hemochromatosis. Clin. Liver Dis. 2020;16:177. doi: 10.1002/cld.987.

González-Domínguez Á., Visiedo-García F.M., Domínguez-Riscart J., González-Domínguez R., Mateos R.M., Lechuga-Sancho A.M. Iron metabolism in obesity and metabolic syndrome. Int. J. Mol. Sci. 2020;21:5529. doi: 10.3390/ijms21155529.

McKay A.K.A., Pyne D.B., Burke L.M., Peeling P. Iron metabolism: Interactions with energy and carbohydrate availability. Nutr. 2020;12:3692. doi: 10.3390/nu12123692.

McCormick R, Moretti D, McKay AKA, Laarakkers CM, Vanswelm R, Trinder D, Cox GR, Zimmerman MB, Sim M, Goodman C, Dawson B, Peeling P. The Impact of Morning versus Afternoon Exercise on Iron Absorption in Athletes. Med Sci Sports Exerc. 2019 Oct;51(10):2147-2155. doi: 10.1249/MSS.0000000000002026. PMID: 31058762.

Costa R.J.S., Snipe R.M.J., Kitic C.M., Gibson P.R. Systematic review: Exercise-induced gastrointestinal syndrome—implications for health and intestinal disease. Aliment. Pharmacol. Ther. 2017;46:246–265. doi: 10.1111/apt.14157.

Lis D., Ahuja K., Stellingwerff T., Kitic C.M. Case Study: Utilizing a Low FODMAP Diet to Combat Exercise-Induced Gastrointestinal Symptoms. Int. J. Sport Nutr. Exerc. Metab. 2016;26:481–487. doi: 10.1123/ijsnem.2015-0293.

Castanier C., Bougault V., Teulier C., Jaffré C., Schiano-Lomoriello S., Vibarel-Rebot N., Villemain A., Rieth N., Le-Scanff C., Buisson C., et al. The Specificities of Elite Female Athletes: A Multidisciplinary Approach. Life. 2021;11:622. doi: 10.3390/life11070622.

Diduch B.K. Gastrointestinal Conditions in the Female Athlete. Clin. Sports Med. 2017;36:655–669. doi: 10.1016/j.csm.2017.06.001.

Dahlquist D.T., Stellingwerff T., Dieter B.P. Effects of macro- and micronutrients on exercise-induced hepcidin response in highly trained endurance athletes. Appl. Physiol. Nutr. Metab. Eff. 2017;42:1036–1043. doi: 10.1139/apnm-2017-0207.

Barney DE, Ippolito JR, Berryman CE, Hennigar SR. A Prolonged Bout of Running Increases Hepcidin and Decreases Dietary Iron Absorption in Trained Female and Male Runners. J Nutr. 2022 Sep 6;152(9):2039-2047. doi: 10.1093/jn/nxac129. PMID: 35661896.

Ishibashi A, Maeda N, Kojima C, Goto K. Iron Metabolism following Twice a Day Endurance Exercise in Female Long-Distance Runners. Nutrients. 2022 May 2;14(9):1907. doi: 10.3390/nu14091907. PMID: 35565873; PMCID: PMC9105615.

Oxfeldt M., Dalgaard L.B., Jørgensen A.A. Hormonal Contraceptive Use, Menstrual Dysfunctions, and Self-Reported Side Effects in Elite Athletes in Denmark. Int. J. Sport Physiol. Perform. 2020;15:1377–1384. doi: 10.1123/ijspp.2019-0636

Quinn K.M., Cox A.J., Roberts L., Pennell E.N., McKeating D.R., Fisher J.J., Perkins A.V., Minahan C. Temporal changes in blood oxidative stress biomarkers across the menstrual cycle and with oral contraceptive use in active women. Graefe’s Arch. Clin. Exp. Ophthalmol. 2021;121:2607–2620. doi: 10.1007/s00421-021-04734-0.

Bruinvels G, Burden R, Brown N, Richards T, Pedlar C. The Prevalence and Impact of Heavy Menstrual Bleeding (Menorrhagia) in Elite and Non-Elite Athletes. PLoS One. 2016 Feb 22;11(2):e0149881. doi: 10.1371/journal.pone.0149881. PMID: 26901873; PMCID: PMC4763330.

International Olympic Committee. IOC Annual Report 2014: Credibility, sustainability and youth [Internet]. Lausanne: IOC; 2015 [cited 2025 Jun 21]. Available from: https://stillmed.olympics.com/media/Document%20Library/OlympicOrg/Documents/IOC-Annual-Report/IOC-Annual-Report-2014.pdf

Cialdella-Kam L., Kulpins D., Manore M.M. Vegetarian, Gluten-Free, and Energy Restricted Diets in Female Athletes. Sports. 2016;4:50. doi: 10.3390/sports4040050.

Mountjoy M., Sundgot-Borgen J.K., Burke L.M., Ackerman K.E., Blauwet C., Constantini N., Lebrun C., Lundy B., Melin A., Meyer N.L., et al. IOC consensus statement on relative energy deficiency in sport (RED-S): 2018 update. Br. J. Sports Med. 2018;52:687–697. doi: 10.1136/bjsports-2018-099193.

Stellingwerff T., Heikura I.A., Meeusen R., Bermon S., Seiler S., Mountjoy M.L., Burke L.M. Overtraining Syndrome (OTS) and Relative Energy Deficiency in Sport (RED-S): Shared Pathways, Symptoms and Complexities. Sport Med. 2021 doi: 10.1007/s40279-021-01491-0.

Sim M., Garvican-Lewis L.A., Cox G., Govus A., McKay A.K.A., Stellingwerff T., Peeling P. Iron considerations for the athlete: A narrative review. Graefe’s Arch. Clin. Exp. Ophthalmol. 2019;119:1463–1478. doi: 10.1007/s00421-019-04157-y.

Lee F.X.Z., Houweling P.J., North K.N., Quinlan K.G.R. How does α-actinin-3 deficiency alter muscle function? Mechanistic insights into ACTN3, the “gene for speed”. Biochim. Biophys. Acta Mol. Cell Res. 2016;1863:686–693. doi: 10.1016/j.bbamcr.2016.01.013.

Sierra A.P.R., Oliveira R.A., Silva E.D., Lima G., Benetti M.P., Kiss M.A.P., Sierra C.A., Ghorayeb N., Seto J.T., Pesquero J.B., et al. Association between hematological parameters and iron metabolism response after marathon race and ACTN3 genotype. Front. Physiol. 2019;10:697. doi: 10.3389/fphys.2019.00697.

Friedlander S.M., Herrmann A.L., Lowry D., Mepham E.R., Lek M., North K.N., Organ C.L. ACTN3 Allele Frequency in Humans Covaries with Global Latitudinal Gradient. PLoS ONE. 2013;8:e52282. doi: 10.1371/journal.pone.0052282.

Hollerer I., Bachmann A., Muckenthaler M.U. Pathophysiological consequences and benefits of HFE mutations: 20 years of research. Haematologica. 2017;102:809–817. doi: 10.3324/haematol.2016.160432.

Carlsohn, A., Müller, S. & Mayer, F. (2024). Approaches to Prevent Iron Deficiency in Athletes. Dtsch Z Sportmed, 75(5), 123–129.

Gibson R.S., Heath A.L.M., Szymlek-Gay E.A. Is iron and zinc nutrition a concern for vegetarian infants and young children in industrialized countries? Am. J. Clin. Nutr. 2014;100:459S–468S. doi: 10.3945/ajcn.113.071241.

Rusu I.G., Vodnar D.C., Pop C.R., Sonia A.S., Vulturar R., Istrati M., Morosan I., Farcas A.C., Kerezsi A.D., Muresan C.I., et al. Iron Supplementation Influence on the Gut Microbiota and Probiotic Intake Effect in Iron Deficiency—A Literature-Based Review. Nutrients. 2020;12:1993. doi: 10.3390/nu12071993.

Pasricha, S.R., Low, M., Thompson, J. et al. (2014). Iron Supplementation Benefits Physical Performance in Women of Reproductive Age: A Systematic Review and Meta-Analysis. J Nutr, 144(6), 906–914.

Fortuny J, Von Gersdorff G, Lassalle R, Linder M, Overbeek J, et al. Use of intravenous iron and risk of anaphylaxis: A multinationalobservational post-authorisation safety study in Europe.Pharmacoepidemiol Drug Saf. 2021; 30: 1447-1457. doi:10.1002/pds.5319

Vinchi F, Castagna A, Costa da Silva M, Busti F, Marchi G, et al. Intravenous Iron Promotes Low-Grade Inflammation in AnemicPatients By Triggering Macrophage Activation. Blood. 2019; 134:957. doi:10.1182/blood-2019-132235

Bielik V., Kolisek M. Bioaccessibility and bioavailability of minerals in relation to a healthy gut microbiome. Int. J. Mol. Sci. 2021;22:6803. doi: 10.3390/ijms22136803.

Liao P., He Q., Zhou X., Ma K., Wen J., Chen H., Li Q., Qin D., Wang H. Repetitive Bouts of Exhaustive Exercise Induces a Systemic Inflammatory Response and Multi-Organ Damage in Rats. Front. Physiol. 2020;11:1–14. doi: 10.3389/fphys.2020.00685.

Alves A.J., Viana J., Cavalcante S.L., Oliveira N.L., Duarte J.A., Mota J., Oliveira J., Ribeiro F. Physical activity in primary and secondary prevention of cardiovascular disease: Overview updated. World J. Cardiol. 2016;8:575–583. doi: 10.4330/wjc.v8.i10.575.

Urakami S., Ogawa K., Oka S., Hayashida M., Hagiwara K., Nagamoto S., Sakaguchi K., Yano A., Kurosawa K., Okaneya T. Macroscopic hematuria caused by running-induced traumatic bladder mucosal contusions. IJU Case Rep. 2019;2:27–29. doi: 10.1002/iju5.12030.

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Published
2025-09-30
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How to Cite
Alina Semianiuk, Lidia Jurczenko, & Marta Miejska-Kamińska. (2025). IMPACT OF ENDURANCE SPORTS ON IRON LEVELS AND ANEMIA RISK IN FEMALE ATHLETES: A REVIEW. International Journal of Innovative Technologies in Social Science, 6(3(47). https://doi.org/10.31435/ijitss.3(47).2025.3874

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