ALZHEIMER’S DISEASE: CURRENT STATE OF KNOWLEDGE, DIAGNOSIS, TREATMENT, AND THE ROLE OF LIFESTYLE IN PREVENTION AND THERAPY
Abstract
Background: Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that leads to gradual memory loss, impaired thinking, and cognitive decline. It is characterized by the accumulation of amyloid plaques and neurofibrillary tangles in the brain, which damage nerve cells. As the disease progresses, patients lose the ability to function independently, resulting in complete dependence on care.
Aim: This review aims to summarize current knowleadge about AD and evidence on dietary and lifestyle factors associated with AD
Material and methods: A narrative review of recent literature was conducted using peer-reviewed articles published in PubMed and Google Scholar.
Results: Based on a literature review, a proper balanced diet, rich in antioxidative and anti-inflammatory nutrients, may have a beneficial effect on the prevention of AD. Additionally, the diet should avoid highly processed foods, rich in saturated and trans fatty acids, and poor quality food, which may increase exposure to the consumption of pollution and toxins, such as heavy metals.
Conclusions: Research, in addition to classical pharmacological treatment and modern imaging techniques, highlights the significant role of lifestyle changes—especially diet and regular physical activity—in the prevention and treatment of AD. Numerous studies indicate that maintaining a healthy, active lifestyle and a proper diet can significantly reduce the risk of developing cognitive impairments and dementia, including AD.
References
Long, J. M., & Holtzman, D. M. (2019). Alzheimer Disease: An Update on Pathobiology and Treatment Strategies. Cell, 179(2), 312–339. https://doi.org/10.1016/j.cell.2019.09.001
Rostagno A. A. (2022). Pathogenesis of Alzheimer's Disease. International journal of molecular sciences, 24(1), 107. https://doi.org/10.3390/ijms24010107
Szczeklik A, Gajewski P, red. Choroby wewnętrzne. Interna Szczeklika 2019. Kraków: Medycyna Praktyczna; 2019
Serrano-Pozo, A., Das, S., & Hyman, B. T. (2021). APOE and Alzheimer's disease: advances in genetics, pathophysiology, and therapeutic approaches. The Lancet. Neurology, 20(1), 68–80. https://doi.org/10.1016/S1474-4422(20)30412-9
Soria Lopez, J. A., González, H. M., & Léger, G. C. (2019). Alzheimer's disease. Handbook of clinical neurology, 167, 231–255. https://doi.org/10.1016/B978-0-12-804766-8.00013-3.
Lane, C. A., Hardy, J., & Schott, J. M. (2018). Alzheimer's disease. European journal of neurology, 25(1), 59–70. https://doi.org/10.1111/ene.13439
Alzheimer's Association. "2018 Alzheimer's disease facts and figures." Alzheimer's & Dementia 14.3 (2018): 367-429.
Khan, S., Barve, K. H., & Kumar, M. S. (2020). Recent Advancements in Pathogenesis, Diagnostics and Treatment of Alzheimer's Disease. Current neuropharmacology, 18(11), 1106–1125. https://doi.org/10.2174/1570159X18666200528142429.
Weller, J., & Budson, A. (2018). Current understanding of Alzheimer's disease diagnosis and treatment. F1000Research, 7, F1000 Faculty Rev-1161. https://doi.org/10.12688/f1000research.14506.1.
Breijyeh, Z., & Karaman, R. (2020). Comprehensive Review on Alzheimer's Disease: Causes and Treatment. Molecules (Basel, Switzerland), 25(24), 5789. https://doi.org/10.3390/molecules25245789
Risk Reduction of Cognitive Decline and Dementia: WHO Guidelines. Geneva: World Health Organization; 2019. 3, Evidence and Recommendations. Available from: https://www.ncbi.nlm.nih.gov/books/NBK542792/
Scheltens, P., De Strooper, B., Kivipelto, M., Holstege, H., Chételat, G., Teunissen, C. E., Cummings, J., & van der Flier, W. M. (2021). Alzheimer's disease. Lancet (London, England), 397(10284), 1577–1590. https://doi.org/10.1016/S0140-6736(20)32205-4
Stefaniak, O., Dobrzyńska, M., Drzymała-Czyż, S., & Przysławski, J. (2022). Diet in the Prevention of Alzheimer's Disease: Current Knowledge and Future Research Requirements. Nutrients, 14(21), 4564. https://doi.org/10.3390/nu14214564
Rusek, M., Pluta, R., Ułamek-Kozioł, M., & Czuczwar, S. J. (2019). Ketogenic Diet in Alzheimer's Disease. International journal of molecular sciences, 20(16), 3892. https://doi.org/10.3390/ijms20163892
Lotfy WA, Ali AM, Abdou HM, Ghanem KM. Neuroprotective and probiotic potential of Lactiplantibacillus plantarum AM2 in cognitive impairment. Sci Rep. 2025 Jun 20;15(1):20186. doi: 10.1038/s41598-025-06103-9. PMID: 40542051; PMCID: PMC12181349.
Stella, F., Canonici, A. P., Gobbi, S., Galduroz, R. F., Cação, J.deC., & Gobbi, L. T. (2011). Attenuation of neuropsychiatric symptoms and caregiver burden in Alzheimer's disease by motor intervention: a controlled trial. Clinics (Sao Paulo, Brazil), 66(8), 1353–1360. https://doi.org/10.1590/s1807-59322011000800008.
Weller, J., & Budson, A. (2018). Current understanding of Alzheimer's disease diagnosis and treatment. F1000Research, 7, F1000 Faculty Rev-1161. https://doi.org/10.12688/f1000research.14506.1.
Briggs, R., Kennelly, S. P., & O'Neill, D. (2016). Drug treatments in Alzheimer's disease. Clinical medicine (London, England), 16(3), 247–253. https://doi.org/10.7861/clinmedicine.16-3-247
Passeri, E., Elkhoury, K., Morsink, M., Broersen, K., Linder, M., Tamayol, A., Malaplate, C., Yen, F. T., & Arab-Tehrany, E. (2022). Alzheimer's Disease: Treatment Strategies and Their Limitations. International journal of molecular sciences, 23(22), 13954. https://doi.org/10.3390/ijms232213954
Cummings, J. L., Tong, G., & Ballard, C. (2019). Treatment Combinations for Alzheimer's Disease: Current and Future Pharmacotherapy Options. Journal of Alzheimer's disease : JAD, 67(3), 779–794. https://doi.org/10.3233/JAD-18076
Hane, F. T., Robinson, M., Lee, B. Y., Bai, O., Leonenko, Z., & Albert, M. S. (2017). Recent Progress in Alzheimer's Disease Research, Part 3: Diagnosis and Treatment. Journal of Alzheimer's disease : JAD, 57(3), 645–665. https://doi.org/10.3233/JAD-160907.
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Copyright (c) 2025 Wiktor Doroszuk, Jakub Hamouta, Dominika Nowak, Patrycja Długosz, Julia Konat, Magdalena Próchnicka, Michał Siwek, Adam Zarzycki, Jan Noskowicz, Jan Urban, Bartosz Skorupski, Natalia Strumnik
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