THE ROLE OF DIET AND MICRONUTRIENTS IN MIGRAINE PREVENTION

Keywords: Migraine, Diet, Micronutrients, Magnesium, Riboflavin, Coenzyme Q10, Vitamin D, Omega-3 Fatty Acids, Prophylaxis

Abstract

Migraine is a chronic neurological disorder characterized by recurrent episodes of throbbing headache, often unilateral, accompanied by symptoms such as nausea, photophobia, and phonophobia. Dietary factors and deficiencies in micronutrients, such as magnesium, riboflavin, coenzyme Q10, vitamin D, and omega-3 fatty acids, play a significant role in modulating the frequency and severity of migraine attacks.

This article analyzes the biological mechanisms linking diet to migraine, the effectiveness of supplementation with selected micronutrients, and the importance of eliminating potential trigger factors, such as tyramine, monosodium glutamate, or aspartame.

Based on a review of scientific literature, including Polish and English-language sources, it was demonstrated that a properly balanced diet, including the Mediterranean and ketogenic diets, and individually tailored supplementation can significantly reduce the risk of migraine attacks. The need for further research to optimize dietary strategies and personalize interventions to improve the quality of life of migraine patients was emphasized.

References

Lipton RB, Bigal ME. Migraine: epidemiology, impact, and risk factors for progression. *Headache*. 2005;45(Suppl 1):S3-S13. doi:10.1111/j.1526-4610.2005.4501001.x

Headache Classification Committee of the International Headache Society (IHS). The International Classification of Headache Disorders, 3rd edition. *Cephalalgia*. 2018;38(1):1-211. doi:10.1177/0333102417738202

Stępień A, Kozubski W. Migrena: patofizjologia i leczenie. *Neurologia Praktyczna*. 2019;3:12-18.

Russell MB, Olesen J. A nosographic analysis of the migraine aura in a general popula-tion. *Brain*. 1996;119(Pt 2):355-361. doi:10.1093/brain/119.2.355

Gazerani P. Migraine and diet. *Nutrients*. 2020;12(6):1658. doi:10.3390/nu12061658

Nowaczewska M, Wiciński M, Kaźmierczak W. The ambiguous role of caffeine in mi-graine headache: from trigger to treatment. *Nutrients*. 2020;12(8):2259. doi:10.3390/nu12082259

Charles AC, Baca SM. Cortical spreading depression and migraine. *Nat Rev Neurol*. 2013;9(11):637-644. doi:10.1038/nrneurol.2013.192

Edvinsson L, Haanes KA, Warfvinge K, Krause DN. CGRP as the target of new migraine therapies — successful translation from bench to clinic. *Nat Rev Neurol*. 2018;14(6):338-350. doi:10.1038/s41582-018-0003-1

Yorns WR, Hardison HH. Mitochondrial dysfunction in migraine. *Semin Pediatr Neu-rol*. 2013;20(3):188-193. doi:10.1016/j.spen.2013.09.002

Longoni M, Ferrarese C. Inflammation and excitotoxicity: role in migraine pathogenesis. *Neurol Sci*. 2006;27(Suppl 2):S107-S110. doi:10.1007/s10072-006-0582-2

Littarru GP, Tiano L. Clinical aspects of coenzyme Q10: an update. *Nutrition*. 2010;26(3):250-254. doi:10.1016/j.nut.2009.08.008

Nappi G, Jensen R, Nappi RE, et al. Food and headache attacks: a review. *Curr Pain Headache Rep*. 2010;14(5):360-366. doi:10.1007/s11916-010-0135-3

Blau JN. Migraine triggers: practice and theory. *Pathol Biol (Paris)*. 1992;40(4):367-372.

Calder PC. Omega-3 fatty acids and inflammatory processes: from molecules to man. *Biochem Soc Trans*. 2017;45(5):1105-1115. doi:10.1042/BST20160474

Mauskop A, Varughese J. Why all migraine patients should be treated with magnesium. *J Neural Transm*. 2012;119(5):575-579. doi:10.1007/s00702-012-0790-2

Welch KM, Ramadan NM. Mitochondria, magnesium and migraine: the Mt. Sinai expe-rience. *Cephalalgia*. 1995;15(Suppl 15):8-12.

Assarzadegan F, Asgarzadeh S, Hatamabadi HR, et al. Serum concentration of magnesi-um as an independent risk factor in migraine attacks: a matched case-control study. *Headache*. 2016;56(9):1418-1423. doi:10.1111/head.12925

Peikert A, Wilimzig C, Köhne-Volland R. Prophylaxis of migraine with oral magnesium: results from a prospective, multi-center, placebo-controlled and double-blind randomized study. *Cephalalgia*. 1996;16(4):257-263. doi:10.1046/j.1468-2982.1996.1604257.x

Chiu HY, Yeh TH, Huang YC, et al. Effects of intravenous and oral magnesium on reduc-ing migraine: a meta-analysis of randomized controlled trials. *Pain Physician*. 2016;19(1):E97-E112.

Ranade VV, Somberg JC. Bioavailability and pharmacokinetics of magnesium after ad-ministration of magnesium salts to humans. *Am J Ther*. 2001;8(5):345-357. doi:10.1097/00045391-200109000-00008

Krzysik M, Biernat J, Grajeta H. Wpływ wybranych składników odżywczych na funkcjo-nowanie układu odpornościowego. *Adv Clin Exp Med*. 2007;16(1):123-133.

Domitrz I, Stępień A. Migrena – leczenie i profilaktyka. *Medycyna po Dyplomie*. 2020;29(4):45-52.

Powers HJ. Riboflavin (vitamin B-2) and health. *Am J Clin Nutr*. 2003;77(6):1352-1360. doi:10.1093/ajcn/77.6.1352

Sparaco M, Feleppa M, Lipton RB, et al. Mitochondrial dysfunction and migraine: evi-dence and hypotheses. *Cephalalgia*. 2006;26(4):361-372. doi:10.1111/j.1468-2982.2005.01059.x

Colombo B, Saraceno L, Comi G. Riboflavin and migraine: the bridge over troubled mi-tochondria. *Neurol Sci*. 2014;35(Suppl 1):141-144. doi:10.1007/s10072-014-1755-9

Schoenen J, Jacquy J, Lenaerts M. Effectiveness of high-dose riboflavin in migraine prophylaxis: a randomized controlled trial. *Neurology*. 1998;50(2):466-470. doi:10.1212/wnl.50.2.466

Boehnke C, Reuter U, Flach U, et al. High-dose riboflavin treatment is efficacious in migraine prophylaxis: an open study in a tertiary care centre. *Eur J Neurol*. 2004;11(7):475-477. doi:10.1111/j.1468-1331.2004.00813.x

Zempleni J, Galloway JR, McCormick DB. Pharmacokinetics of orally and intravenously administered riboflavin in healthy humans. *Am J Clin Nutr*. 1996;63(1):54-66. doi:10.1093/ajcn/63.1.54

Narodowe Centrum Edukacji Żywieniowej. Witaminy rozpuszczalne w wodzie – rola w organizmie. 2018. [Dostęp: 2025-04-29].

Evers S, Afra J, Frese A, et al. EFNS guideline on the drug treatment of migraine – re-vised report of an EFNS task force. *Eur J Neurol*. 2009;16(9):968-981. doi:10.1111/j.1468-1331.2009.02748.x

Littarru GP, Tiano L. Clinical aspects of coenzyme Q10: an update. *Nutrition*. 2010;26(3):250-254. doi:10.1016/j.nut.2009.08.008

Markley HG. Coenzyme Q10 and riboflavin: the mitochondrial connection. *Headache*. 2012;52(Suppl 2):81-87. doi:10.1111/j.1526-4610.2012.02233.x

Hershey AD, Powers SW, Vockell AL, et al. Coenzyme Q10 deficiency and response to supplementation in pediatric and adolescent migraine. *Headache*. 2007;47(1):73-80. doi:10.1111/j.1526-4610.2007.00652.x

Sándor PS, Di Clemente L, Coppola G, et al. Efficacy of coenzyme Q10 in migraine prophylaxis: a randomized controlled trial. *Neurology*. 2005;64(4):713-715. doi:10.1212/01.WNL.0000151975.03581.ED

Hershey AD, Powers SW, Vockell AL, et al. Coenzyme Q10 deficiency and response to supplementation in pediatric and adolescent migraine. *Headache*. 2007;47(1):73-80. doi:10.1111/j.1526-4610.2007.00652.x

Gaul C, Diener HC, Danesch U, et al. Improvement of migraine symptoms with a propri-etary supplement containing riboflavin, magnesium, and CoQ10: a randomized, placebo-controlled, double-blind, multicenter trial. *J Headache Pain*. 2015;16:516. doi:10.1186/s10194-015-0516-6

Pravst I, Zmitek K, Zmitek J. Coenzyme Q10 contents in foods and fortification strate-gies. *Crit Rev Food Sci Nutr*. 2010;50(4):269-280. doi:10.1080/10408391003665529

Rożniecki JJ. Rola diety w leczeniu migreny. *Food Forum*. 2020;4:22-28.

Holick MF. Vitamin D deficiency. *N Engl J Med*. 2007;357(3):266-281. doi:10.1056/NEJMra070553

Wrzosek M, Łukaszkiewicz J, Jakubczyk A, et al. Witamina D a zdrowie: znaczenie w profilaktyce i leczeniu. *Postępy Hig Med Dośw*. 2013;67:363-371. doi:10.5604/17322693.1048273

Prakash S, Shah ND. Chronic tension-type headache with vitamin D deficiency: casual or causal association? *Headache*. 2009;49(8):1214-1222. doi:10.1111/j.1526-4610.2009.01483.x

Celikbilek A, Gocmen AY, Zararsiz G, et al. Serum levels of vitamin D, vitamin D-binding protein and vitamin D receptor in migraine patients. *J Headache Pain*. 2014;15:68. doi:10.1186/1129-2377-15-68

Mottaghi T, Khorvash F, Maracy MR, et al. Effect of vitamin D supplementation on symptoms and C-reactive protein in migraine patients. *J Res Med Sci*. 2015;20(5):477-482. doi:10.4103/1735-1995.163964

Buettner C, Burstein R. Vitamin D and headaches: a systematic review. *Headache*. 2018;58(8):1256-1267. doi:10.1111/head.13373

Pludowski P, Holick MF, Grant WB, et al. Vitamin D supplementation guidelines. *J Steroid Biochem Mol Biol*. 2018;175:125-135. doi:10.1016/j.jsbmb.2017.01.021

Vieth R. Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety. *Am J Clin Nutr*. 1999;69(5):842-856. doi:10.1093/ajcn/69.5.842

Calder PC. Omega-3 fatty acids and inflammatory processes: from molecules to man. *Biochem Soc Trans*. 2017;45(5):1105-1115. doi:10.1042/BST20160474

Simopoulos AP. Omega-3 fatty acids in inflammation and autoimmune diseases. *J Am Coll Nutr*. 2002;21(6):495-505. doi:10.1080/07315724.2002.10719248

Ramsden CE, Faurot KR, Zamora D, et al. Targeted alteration of dietary n-3 and n-6 fatty acids for the treatment of chronic headaches: a randomized trial. *Pain*. 2013;154(11):2441-2451. doi:10.1016/j.pain.2013.07.028

Maghsoumi-Norouzabad L, Mansoori A, Abed R, et al. Effects of omega-3 fatty acids on the frequency, severity, and duration of migraine attacks: a systematic review and meta-analysis of randomized controlled trials. *Nutr Neurosci*. 2021;24(12):961-970. doi:10.1080/1028415X.2019.1697815

Altamura C, Cecchi G, Bravo M, et al. The Healthy Eating Plate advice for migraine pre-vention: an interventional study. *Nutrients*. 2020;12(6):1579. doi:10.3390/nu12061579

Szponar L, Respondek W. Kwasy tłuszczowe w żywieniu człowieka. *Żywienie Człowieka i Metabolizm*. 2011;38(3):135-147.

Simopoulos AP. The importance of the omega-6/omega-3 fatty acid ratio in cardiovascu-lar disease and other chronic diseases. *Exp Biol Med (Maywood)*. 2008;233(6):674-688. doi:10.3181/0711-MR-311

Finocchi C, Sivori G. Food as trigger and aggravating factor of migraine. *Neurol Sci*. 2012;33(Suppl 1):S77-S80. doi:10.1007/s10072-012-1046-5

Hanington E. The role of tyramine in the aetiology of migraine, and related studies on the cerebral and extracerebral circulations. *Headache*. 1967;7(3):92-98. doi:10.1111/j.1526-4610.1967.hed0703092.x

Martin VT, Vij B. Diet and headache: part 1. *Headache*. 2016;56(9):1543-1552. doi:10.1111/head.12953

Freeman M. Reconsidering the effects of monosodium glutamate: a literature review. *J Am Acad Nurse Pract*. 2006;18(10):482-486. doi:10.1111/j.1745-7599.2006.00160.x

Martin VT, Vij B. Diet and headache: part 2. *Headache*. 2016;56(10):1553-1562. doi:10.1111/head.12954

Lindseth GN, Coolahan SE, Petros TV, et al. Neurobehavioral effects of aspartame con-sumption. *Res Nurs Health*. 2014;37(3):185-193. doi:10.1002/nur.21595

Nowaczewska M, Wiciński M, Kaźmierczak W. To eat or not to eat: a review of the rela-tionship between chocolate and migraines. *Nutrients*. 2020;12(3):608. doi:10.3390/nu12030608

Nowaczewska M, Wiciński M, Kaźmierczak W. The ambiguous role of caffeine in mi-graine headache: from trigger to treatment. *Nutrients*. 2020;12(8):2259. doi:10.3390/nu12082259

Hindiyeh NA, Zhang N, Farrar M, et al. The role of diet and nutrition in migraine trig-gers and treatment: a systematic literature review. *Headache*. 2020;60(7):1300-1316. doi:10.1111/head.13836

Blau JN. Migraine triggers: practice and theory. *Pathol Biol (Paris)*. 1992;40(4):367-372.

Narodowe Centrum Edukacji Żywieniowej. Migrena a dieta i inne czynniki stylu życia. 2019. [Dostęp: 2025-04-29].

Jenkins DJ, Kendall CW, Augustin LS, et al. Glycemic index: overview of implications in health and disease. *Am J Clin Nutr*. 2002;76(1):266S-273S. doi:10.1093/ajcn/76/1.266S

Masino SA, Rho JM. Mechanisms of ketogenic diet action. *Epilepsia*. 2010;51(Suppl 5):85. doi:10.1111/j.1528-1167.2010.02833.x

Gross EC, Klement RJ, Schoenen J, et al. Potential protective mechanisms of ketone bodies in migraine prevention. *Nutrients*. 2019;11(4):811. doi:10.3390/nu11040811

Di Lorenzo C, Coppola G, Sirianni G, et al. Migraine improvement during short lasting ketogenesis: a proof-of-concept study. *Eur J Neurol*. 2015;22(1):170-177. doi:10.1111/ene.12550

Gross EC, Klement RJ, Schoenen J, et al. Potential protective mechanisms of ketone bodies in migraine prevention. *Nutrients*. 2019;11(4):811. doi:10.3390/nu11040811

Barbanti P, Fofi L, Aurilia C, et al. Ketogenic diet in migraine: rationale, findings, and perspectives. *Neurol Sci*. 2017;38(Suppl 1):111-115. doi:10.1007/s10072-017-2889-6

Willett WC, Sacks F, Trichopoulou A, et al. Mediterranean diet pyramid: a cultural mod-el for healthy eating. *Am J Clin Nutr*. 1995;61(6 Suppl):1402S-1406S. doi:10.1093/ajcn/61.6.1402S

Estruch R, Ros E, Salas-Salvadó J, et al. Primary prevention of cardiovascular disease with a Mediterranean diet supplemented with extra-virgin olive oil or nuts. *N Engl J Med*. 2018;378(25):e34. doi:10.1056/NEJMoa1800389

Altamura C, Cecchi G, Bravo M, et al. The Healthy Eating Plate advice for migraine pre-vention: an interventional study. *Nutrients*. 2020;12(6):1579. doi:10.3390/nu12061579

Trichopoulou A, Costacou T, Bamia C, et al. Adherence to a Mediterranean diet and sur-vival in a Greek population. *N Engl J Med*. 2003;348(26):2599-2608. doi:10.1056/NEJMoa025039

Szponar L, Respondek W. Żywienie w profilaktyce chorób przewlekłych. *Żywienie Człowieka i Metabolizm*. 2012;39(2):89-102.

Pross N. Effects of dehydration on brain functioning: a life-span perspective. *Ann Nutr Metab*. 2017;70(Suppl 1):30-36. doi:10.1159/000463060

Popkin BM, D’Anci KE, Rosenberg IH. Water, hydration, and health. *Nutr Rev*. 2010;68(8):439-458. doi:10.1111/j.1753-4887.2010.00304.x

Evers S, Afra J, Frese A, et al. EFNS guideline on the drug treatment of migraine – re-vised report of an EFNS task force. *Eur J Neurol*. 2009;16(9):968-981. doi:10.1111/j.1468-1331.2009.02748.x

Slavin M, Ailani J. A clinical approach to addressing diet with migraine patients. *Curr Neurol Neurosci Rep*. 2017;17(2):17. doi:10.1007/s11910-017-0721-1

Hindiyeh NA, Zhang N, Farrar M, et al. The role of diet and nutrition in migraine trig-gers and treatment: a systematic literature review. *Headache*. 2020;60(7):1300-1316. doi:10.1111/head.13836

Popkin BM, D’Anci KE, Rosenberg IH. Water, hydration, and health. *Nutr Rev*. 2010;68(8):439-458. doi:10.1111/j.1753-4887.2010.00304.x

Rożniecki JJ, Stępień A, Domitrz I. Leczenie migreny przewlekłej – zalecenia. *Polskie Towarzystwo Bólów Głowy*. 2020.

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Published
2025-09-30
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Patrycja Świercz, Konrad Strużek, Agnieszka Kwiatkowska, Ewelina Mączka, Wiktor Tracz, Kinga Teper, Sandra Khiralla-Gawlik, Aleksandra Anna Strzelecka, Aleksandra Ewa Basak, & Jakub Tomaszewski. (2025). THE ROLE OF DIET AND MICRONUTRIENTS IN MIGRAINE PREVENTION. International Journal of Innovative Technologies in Social Science, 5(3(47). https://doi.org/10.31435/ijitss.3(47).2025.3667

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