ENERGY DRINKS IN YOUTH: CARDIOVASCULAR, NEUROPSYCHIATRIC, AND POLICY PERSPECTIVES — A NARRATIVE REVIEW
Abstract
Introduction and Objective: Energy drink (ED) consumption has markedly increased among adolescents and young adults, raising clinical and public-health concerns. Evidence links EDs to acute cardiovascular, neuropsychiatric, and metabolic disturbances, yet findings remain fragmented. This narrative review aimed to synthesize recent data on physiological effects, behavioral correlates, and regulatory responses to ED use in youth.
Materials and Methods: A narrative search of PubMed (1990–October 2025) identified randomized and crossover trials, observational studies, and PubMed-indexed reviews addressing ED exposure among individuals aged 10–35 years. Six domains were analyzed: cardiovascular, neuropsychiatric, metabolic/gastrointestinal/dental, sport performance, policy and labeling, and medication interactions.
Results: Evidence consistently indicates transient increases in systolic and diastolic blood pressure, heart-rate variability changes, and QTc prolongation following ED intake. Cross-sectional and longitudinal studies associate frequent ED consumption with reduced sleep duration, anxiety, depressive symptoms, and higher stress scores. Metabolic data show elevated insulin and glucose levels and rare cases of niacin-related hepatotoxicity. Co-use of EDs with alcohol amplifies risk-taking behaviors and cardiovascular strain. Despite labeling restrictions, marketing continues to target youth, with variable national policy enforcement.
Conclusions: ED use among adolescents and young adults exerts measurable short-term cardiovascular and neuropsychiatric effects and contributes to risky behavior patterns. Preventive efforts should combine clinical counseling on caffeine and alcohol co-use with regulatory strategies addressing marketing and accessibility.
References
Gualberto, P. I. B., Benvindo, V. V., Waclawovsky, G., & Deresz, L. F. (2024). Acute effects of energy drink consumption on cardiovascular parameters in healthy adults: a systematic review and meta-analysis of randomized clinical trials. Nutrition reviews, 82(8), 1028–1045. https://doi.org/10.1093/nutrit/nuad112
Kaldenbach, S., Hysing, M., Strand, T. A., & Sivertsen, B. (2024). Energy drink consumption and sleep parameters in college and university students: a national cross-sectional study. BMJ open, 14(2), e072951. https://doi.org/10.1136/bmjopen-2023-072951
Wassef, B., Kohansieh, M., & Makaryus, A. N. (2017). Effects of energy drinks on the cardiovascular system. World journal of cardiology, 9(11), 796–806. https://doi.org/10.4330/wjc.v9.i11.796
Shah, S. A., Szeto, A. H., Farewell, R., Shek, A., Fan, D., Quach, K. N., Bhattacharyya, M., Elmiari, J., Chan, W., O'Dell, K., Nguyen, N., McGaughey, T. J., Nasir, J. M., & Kaul, S. (2019). Impact of High Volume Energy Drink Consumption on Electrocardiographic and Blood Pressure Parameters: A Randomized Trial. Journal of the American Heart Association, 8(11), e011318. https://doi.org/10.1161/JAHA.118.011318
Basrai, M., Schweinlin, A., Menzel, J., Mielke, H., Weikert, C., Dusemund, B., Putze, K., Watzl, B., Lampen, A., & Bischoff, S. C. (2019). Energy Drinks Induce Acute Cardiovascular and Metabolic Changes Pointing to Potential Risks for Young Adults: A Randomized Controlled Trial. The Journal of nutrition, 149(3), 441–450. https://doi.org/10.1093/jn/nxy303
Temple, J. L., Bernard, C., Lipshultz, S. E., Czachor, J. D., Westphal, J. A., & Mestre, M. A. (2017). The Safety of Ingested Caffeine: A Comprehensive Review. Frontiers in psychiatry, 8, 80. https://doi.org/10.3389/fpsyt.2017.00080
Curran, C. P., & Marczinski, C. A. (2017). Taurine, caffeine, and energy drinks: Reviewing the risks to the adolescent brain. Birth defects research, 109(20), 1640–1648. https://doi.org/10.1002/bdr2.1177
Rostami, M., Babashahi, M., Ramezani, S., & Dastgerdizad, H. (2024). A scoping review of policies related to reducing energy drink consumption in children. BMC public health, 24(1), 2308. https://doi.org/10.1186/s12889-024-19724-y
Marinoni, M., Parpinel, M., Gasparini, A., Ferraroni, M., & Edefonti, V. (2022). Risky behaviors, substance use, and other lifestyle correlates of energy drink consumption in children and adolescents: a systematic review. European journal of pediatrics, 181(4), 1307–1319. https://doi.org/10.1007/s00431-021-04322-6
Marinoni, M., Parpinel, M., Gasparini, A., Ferraroni, M., & Edefonti, V. (2022). Psychological and socio-educational correlates of energy drink consumption in children and adolescents: a systematic review. European journal of pediatrics, 181(3), 889–901. https://doi.org/10.1007/s00431-021-04321-7
Jagim, A. R., Harty, P. S., Barakat, A. R., Erickson, J. L., Carvalho, V., Khurelbaatar, C., Camic, C. L., & Kerksick, C. M. (2022). Prevalence and Amounts of Common Ingredients Found in Energy Drinks and Shots. Nutrients, 14(2), 314. https://doi.org/10.3390/nu14020314
Oberhoffer, F. S., Dalla-Pozza, R., Jakob, A., Haas, N. A., Mandilaras, G., & Li, P. (2023). Energy drinks: effects on pediatric 24-h ambulatory blood pressure monitoring. A randomized trial. Pediatric research, 94(3), 1172–1179. https://doi.org/10.1038/s41390-023-02598-y
Costa, R., Rocha, C., & Santos, H. (2023). Cardiovascular and Cerebrovascular Response to RedBull® Energy Drink Intake in Young Adults. Anatolian journal of cardiology, 27(1), 19–25. https://doi.org/10.14744/AnatolJCardiol.2022.2315
Lasheras, I., Seral, P., Alonso-Ventura, V., & Santabárbara, J. (2021). The impact of acute energy drink consumption on electrical heart disease: A systematic review and meta-analysis. Journal of electrocardiology, 65, 128–135. https://doi.org/10.1016/j.jelectrocard.2021.01.020
Azarm, V., Link, J. P., Mandilaras, G., Li, P., Dalla-Pozza, R., Jakob, A., Haas, N. A., Oberhoffer, F. S., & Schrader, M. (2024). Acute Cardiovascular Effects of Simultaneous Energy Drink and Alcohol Consumption in Young Adults: A Review of Case Reports. Pediatric reports, 16(3), 618–630. https://doi.org/10.3390/pediatric16030052
Lévy, S., Santini, L., Capucci, A., Oto, A., Santomauro, M., Riganti, C., Raviele, A., & Cappato, R. (2019). European Cardiac Arrhythmia Society Statement on the cardiovascular events associated with the use or abuse of energy drinks. Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing, 56(1), 99–115. https://doi.org/10.1007/s10840-019-00610-2
Grasser, E. K., Yepuri, G., Dulloo, A. G., & Montani, J. P. (2014). Cardio- and cerebrovascular responses to the energy drink Red Bull in young adults: a randomized cross-over study. European journal of nutrition, 53(7), 1561–1571. https://doi.org/10.1007/s00394-014-0661-8
Papaioannou, T. G., Karatzi, K., Karatzis, E., Papamichael, C., & Lekakis, J. P. (2005). Acute effects of caffeine on arterial stiffness, wave reflections, and central aortic pressures. American journal of hypertension, 18(1), 129–136. https://doi.org/10.1016/j.amjhyper.2004.08.017
Li, P., Mandilaras, G., Jakob, A., Dalla-Pozza, R., Haas, N. A., & Oberhoffer, F. S. (2022). Energy Drinks and Their Acute Effects on Arterial Stiffness in Healthy Children and Teenagers: A Randomized Trial. Journal of clinical medicine, 11(8), 2087. https://doi.org/10.3390/jcm11082087
Ehlers, A., Marakis, G., Lampen, A., & Hirsch-Ernst, K. I. (2019). Risk assessment of energy drinks with focus on cardiovascular parameters and energy drink consumption in Europe. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 130, 109–121. https://doi.org/10.1016/j.fct.2019.05.028
Darpo, B., Nebout, T., & Sager, P. T. (2006). Clinical evaluation of QT/QTc prolongation and proarrhythmic potential for nonantiarrhythmic drugs: the International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use E14 guideline. Journal of clinical pharmacology, 46(5), 498–507. https://doi.org/10.1177/0091270006286436
Mandilaras, G., Li, P., Dalla-Pozza, R., Haas, N. A., & Oberhoffer, F. S. (2022). Energy Drinks and Their Acute Effects on Heart Rhythm and Electrocardiographic Time Intervals in Healthy Children and Teenagers: A Randomized Trial. Cells, 11(3), 498. https://doi.org/10.3390/cells11030498
La Vieille, S., Gillespie, Z., Bonvalot, Y., Benkhedda, K., Grinberg, N., Rotstein, J., Barber, J., & Krahn, A. D. (2021). Caffeinated energy drinks in the Canadian context: health risk assessment with a focus on cardiovascular effects. Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme, 46(9), 1019–1028. https://doi.org/10.1139/apnm-2021-0245
Kaldenbach, S., Leonhardt, M., Lien, L., Bjærtnes, A. A., Strand, T. A., & Holten-Andersen, M. N. (2022). Sleep and energy drink consumption among Norwegian adolescents - a cross-sectional study. BMC public health, 22(1), 534. https://doi.org/10.1186/s12889-022-12972-w
Kaldenbach, S., Hysing, M., Strand, T. A., & Sivertsen, B. (2024). Energy drink consumption and sleep parameters in college and university students: a national cross-sectional study. BMJ open, 14(2), e072951. https://doi.org/10.1136/bmjopen-2023-072951
Tomanic, M., Paunovic, K., Lackovic, M., Djurdjevic, K., Nestorovic, M., Jakovljevic, A., & Markovic, M. (2022). Energy Drinks and Sleep among Adolescents. Nutrients, 14(18), 3813. https://doi.org/10.3390/nu14183813
Trapp, G. S., Hurworth, M., Jacoby, P., Maddison, K., Allen, K., Martin, K., Christian, H., Ambrosini, G. L., Oddy, W., & Eastwood, P. R. (2021). Energy drink intake is associated with insomnia and decreased daytime functioning in young adult females. Public health nutrition, 24(6), 1328–1337. https://doi.org/10.1017/S1368980020001652
Kim, D. H., Kim, B., Lee, S. G., & Kim, T. H. (2023). Poor sleep is associated with energy drinks consumption among Korean adolescents. Public health nutrition, 26(12), 3256–3265. https://doi.org/10.1017/S136898002300191X
Cho, J. A., Kim, S., Shin, H., Kim, H., & Park, E. C. (2024). The Association between High-Caffeine Drink Consumption and Anxiety in Korean Adolescents. Nutrients, 16(6), 794. https://doi.org/10.3390/nu16060794
Maraqa, B., Fasfoos, A., Alami, M., Banat, N., Amr, O., & Saraheen, A. (2025). Energy drinks, depression, insomnia, and stress in palestinian adolescents: a cross-sectional study. International journal of adolescent medicine and health, 37(1), 35–43. https://doi.org/10.1515/ijamh-2024-0178
Nimri, L., Mansour, B., Benhos, A., Banna, A., Nasrallah, E., Sackran, M., Ahmad, A. A., Ardi, Z., & Horovitz, O. (2024). Energy drink consumption among Israeli-Arab adolescents: Gender differences in anxiety and well-being. Public health challenges, 3(3), e187. https://doi.org/10.1002/puh2.187
Kaur, S., Christian, H., Cooper, M. N., Francis, J., Allen, K., & Trapp, G. (2020). Consumption of energy drinks is associated with depression, anxiety, and stress in young adult males: Evidence from a longitudinal cohort study. Depression and anxiety, 37(11), 1089–1098. https://doi.org/10.1002/da.23090]
Higbee, M. R., Gipson, C. S., & El-Saidi, M. (2022). Caffeine Consumption Habits, Sleep Quality, Sleep Quantity, and Perceived Stress of Undergraduate Nursing Students. Nurse educator, 47(2), 120–124. https://doi.org/10.1097/NNE.0000000000001062
Brunborg, G. S., Raninen, J., & Burdzovic Andreas, J. (2022). Energy drinks and alcohol use among adolescents: A longitudinal study. Drug and alcohol dependence, 241, 109666. https://doi.org/10.1016/j.drugalcdep.2022.109666
Biggio, F., Talani, G., Asuni, G. P., Bassareo, V., Boi, M., Dazzi, L., Pisu, M. G., Porcu, P., Sanna, E., Sanna, F., Serra, M., Serra, M. P., Siddi, C., Acquas, E., Follesa, P., & Quartu, M. (2024). Mixing energy drinks and alcohol during adolescence impairs brain function: A study of rat hippocampal plasticity. Neuropharmacology, 254, 109993. https://doi.org/10.1016/j.neuropharm.2024.109993
Petribu, B. N., Abrahao, K. P., & Souza-Formigoni, M. L. O. (2023). Ethanol combined with energy drinks: Two decades of research in rodents. Frontiers in behavioral neuroscience, 16, 1100608. https://doi.org/10.3389/fnbeh.2022.1100608
Vieno, A., Canale, N., Potente, R., Scalese, M., Griffiths, M. D., & Molinaro, S. (2018). The multiplicative effect of combining alcohol with energy drinks on adolescent gambling. Addictive behaviors, 82, 7–13. https://doi.org/10.1016/j.addbeh.2018.01.034
Marczinski, C. A., Stamates, A. L., & Maloney, S. F. (2018). Differential development of acute tolerance may explain heightened rates of impaired driving after consumption of alcohol mixed with energy drinks versus alcohol alone. Experimental and clinical psychopharmacology, 26(2), 147–155. https://doi.org/10.1037/pha0000173
Milazzo, N. A., Cao, D. X., Diwaker, G., Thornton, J. A., & Shah, S. A. (2021). A Survey of Energy Drink Consumption and Associated Adverse Effects in Air Force Personnel. Military medicine, 186(1-2), e143–e148. https://doi.org/10.1093/milmed/usaa362
Naveh, G., Mansour, B., Bader, M., Steckler, R., Nasrallah, E., Hujeyrat, H., Magzal, F., Elias, N., Horovitz, O., & Nimri, L. (2024). Physiological Impacts of Energy Drink Consumption: A Clinical Analysis in Adolescents. Nutrients, 16(14), 2328. https://doi.org/10.3390/nu16142328
von Bremen, J., Kloukos, D., Bettenhäuser-Hartung, L., & Schmid, J. Q. (2025). Energy drink-induced white spot lesions on labial and lingual tooth surfaces in adolescents treated with lingual appliances: a retrospective cohort study. Clinical oral investigations, 29(7), 370. https://doi.org/10.1007/s00784-025-06445-8
Barajas-Torres, G. C., Klünder-Klünder, M., Garduño-Espinosa, J., Parra-Ortega, I., Franco-Hernández, M. I., & Miranda-Lora, A. L. (2022). Effects of Carbonated Beverage Consumption on Oral pH and Bacterial Proliferation in Adolescents: A Randomized Crossover Clinical Trial. Life (Basel, Switzerland), 12(11), 1776. https://doi.org/10.3390/life12111776
. Vivekanandarajah, A., Ni, S., & Waked, A. (2011). Acute hepatitis in a woman following excessive ingestion of an energy drink: a case report. Journal of medical case reports, 5, 227. https://doi.org/10.1186/1752-1947-5-227
Harb, J. N., Taylor, Z. A., Khullar, V., & Sattari, M. (2016). Rare cause of acute hepatitis: a common energy drink. BMJ case reports, 2016, bcr2016216612. https://doi.org/10.1136/bcr-2016-216612
Huang, B., Kunkel, D., & Kabany, M. E. (2014). Acute Liver Failure Following One Year of Daily Consumption of a Sugar-Free Energy Drink. ACG case reports journal, 1(4), 214–216. https://doi.org/10.14309/crj.2014.57
Jesse, B. D., Nguyen, N. V., & Balasanova, A. A. (2024). Acute Liver Failure and Liver Transplant After Excessive Energy Drink Consumption. The primary care companion for CNS disorders, 26(1), 23cr03613. https://doi.org/10.4088/PCC.23cr03613
De Sanctis, V., Soliman, N., Soliman, A. T., Elsedfy, H., Di Maio, S., El Kholy, M., & Fiscina, B. (2017). Caffeinated energy drink consumption among adolescents and potential health consequences associated with their use: a significant public health hvd. Acta bio-medica : Atenei Parmensis, 88(2), 222–231. https://doi.org/10.23750/abm.v88i2.6664
Falk, B., Burstein, R., Rosenblum, J., Shapiro, Y., Zylber-Katz, E., & Bashan, N. (1990). Effects of caffeine ingestion on body fluid balance and thermoregulation during exercise. Canadian journal of physiology and pharmacology, 68(7), 889–892. https://doi.org/10.1139/y90-135
Millard-Stafford, M. L., Cureton, K. J., Wingo, J. E., Trilk, J., Warren, G. L., & Buyckx, M. (2007). Hydration during exercise in warm, humid conditions: effect of a caffeinated sports drink. International journal of sport nutrition and exercise metabolism, 17(2), 163–177. https://doi.org/10.1123/ijsnem.17.2.163
John, K., Kathuria, S., Peel, J., Page, J., Aitkenhead, R., Felstead, A., Heffernan, S. M., Jeffries, O., Tallent, J., & Waldron, M. (2024). Caffeine ingestion compromises thermoregulation and does not improve cycling time to exhaustion in the heat amongst males. European journal of applied physiology, 124(8), 2489–2502. https://doi.org/10.1007/s00421-024-05460-z
Del Coso, J., Estevez, E., & Mora-Rodriguez, R. (2009). Caffeine during exercise in the heat: thermoregulation and fluid-electrolyte balance. Medicine and science in sports and exercise, 41(1), 164–173. https://doi.org/10.1249/MSS.0b013e318184f45e
Najberg, H., Mouthon, M., Coppin, G., & Spierer, L. (2023). Reduction in sugar drink valuation and consumption with gamified executive control training. Scientific reports, 13(1), 10659. https://doi.org/10.1038/s41598-023-36859-x
Pałka, T., Rydzik, Ł., Koteja, P. M., Piotrowska, A., Bagińska, M., Ambroży, T., Angelova-Igova, B., Javdaneh, N., Wiecha, S., Filip-Stachnik, A., & Tota, Ł. (2024). Effect of Various Hydration Strategies on Work Intensity and Selected Physiological Indices in Young Male Athletes during Prolonged Physical Exercise at High Ambient Temperatures. Journal of clinical medicine, 13(4), 982. https://doi.org/10.3390/jcm13040982
Bergeron, M. F., Waller, J. L., & Marinik, E. L. (2006). Voluntary fluid intake and core temperature responses in adolescent tennis players: sports beverage versus water. British journal of sports medicine, 40(5), 406–410. https://doi.org/10.1136/bjsm.2005.023333
Amiri, M., Ghiasvand, R., Kaviani, M., Forbes, S. C., & Salehi-Abargouei, A. (2019). Chocolate milk for recovery from exercise: a systematic review and meta-analysis of controlled clinical trials. European journal of clinical nutrition, 73(6), 835–849. https://doi.org/10.1038/s41430-018-0187-x
Nguyen, M., Jarvis, S. E., Tinajero, M. G., Yu, J., Chiavaroli, L., Mejia, S. B., Khan, T. A., Tobias, D. K., Willett, W. C., Hu, F. B., Hanley, A. J., Birken, C. S., Sievenpiper, J. L., & Malik, V. S. (2023). Sugar-sweetened beverage consumption and weight gain in children and adults: a systematic review and meta-analysis of prospective cohort studies and randomized controlled trials. The American journal of clinical nutrition, 117(1), 160–174. https://doi.org/10.1016/j.ajcnut.2022.11.008
Cho H. W. (2018). How Much Caffeine is Too Much for Young Adolescents?. Osong public health and research perspectives, 9(6), 287–288. https://doi.org/10.24171/j.phrp.2018.9.6.01
Committee on Nutrition and the Council on Sports Medicine and Fitness (2011). Sports drinks and energy drinks for children and adolescents: are they appropriate?. Pediatrics, 127(6), 1182–1189. https://doi.org/10.1542/peds.2011-0965
Jean G. (2017). How can we restrict the sale of sports and energy drinks to children? A proposal for a World Health Organization-sponsored framework convention to restrict the sale of sports and energy drinks. Australian dental journal, 62(4), 420–425. https://doi.org/10.1111/adj.12520
Wierzejska, R. E., Taraszewska, A. M., Wiosetek-Reske, A., & Poznańska, A. (2025). Consumption of Energy Drinks and Attitudes Among School Students Following the Ban on Sales to Minors in Poland. Nutrients, 17(19), 3167. https://doi.org/10.3390/nu17193167
Temple J. L. (2009). Caffeine use in children: what we know, what we have left to learn, and why we should worry. Neuroscience and biobehavioral reviews, 33(6), 793–806. https://doi.org/10.1016/j.neubiorev.2009.01.001
Hammond, D., & Reid, J. L. (2018). Exposure and perceptions of marketing for caffeinated energy drinks among young Canadians. Public health nutrition, 21(3), 535–542. https://doi.org/10.1017/S1368980017002890
Mandilaras, G., Li, P., Dalla-Pozza, R., Jakob, A., Haas, N. A., & Oberhoffer, F. S. (2025). Impact of Acute Energy Drink Consumption on Heart Rate Variability in Children and Adolescents. A Randomized Trial. Pediatric cardiology, 10.1007/s00246-025-03770-3. Advance online publication. https://doi.org/10.1007/s00246-025-03770-3
Yaşar, S., Geneş, M., Eravcı, Ö., Arslan, A., Şirin, H., Görmel, S., Fırtına, S., Karpat, M. S., Barçın, C., & Çelik, M. (2025). Evaluating the Acute Effects of Energy Drink Consumption on Arterial Stiffness in Healthy Young Adults. Anatolian journal of cardiology, 29(10), 564–570. Advance online publication. https://doi.org/10.14744/AnatolJCardiol.2025.5210
Ajibo, C., Van Griethuysen, A., Visram, S., & Lake, A. A. (2024). Consumption of energy drinks by children and young people: a systematic review examining evidence of physical effects and consumer attitudes. Public health, 227, 274–281. https://doi.org/10.1016/j.puhe.2023.08.024
Khouja, C., Kneale, D., Brunton, G., Raine, G., Stansfield, C., Sowden, A., Sutcliffe, K., & Thomas, J. (2022). Consumption and effects of caffeinated energy drinks in young people: an overview of systematic reviews and secondary analysis of UK data to inform policy. BMJ open, 12(2), e047746. https://doi.org/10.1136/bmjopen-2020-047746
World Health Organization (WHO) WHO manual on sugar-sweetened beverage taxation policies to promote healthy diets. Geneva: World Health Organization; 2022. [cited October 19 2025].Available from: https://www.who.int/publications/i/item/9789240056299
Muth, N. D., Dietz, W. H., Magge, S. N., Johnson, R. K., AMERICAN ACADEMY OF PEDIATRICS, SECTION ON OBESITY, COMMITTEE ON NUTRITION, & AMERICAN HEART ASSOCIATION (2019). Public Policies to Reduce Sugary Drink Consumption in Children and Adolescents. Pediatrics, 143(4), e20190282. https://doi.org/10.1542/peds.2019-0282
Rostami, M., Babashahi, M., Karimi, M., & Khodakarim, S. (2025). Developing policy recommendations for controlling energy drink consumption in secondary school students using social marketing theory, Shiraz, Iran: A study protocol. PloS one, 20(4), e0321766. https://doi.org/10.1371/journal.pone.0321766
Fletcher, A., Jamal, F., Fitzgerald-Yau, N., & Bonell, C. (2013). ‘We’ve Got Some Underground Business Selling Junk Food’: Qualitative Evidence of the Unintended Effects of English School Food Policies. Sociology, 48(3), 500-517. https://doi.org/10.1177/0038038513500102
Sundborn, G., Thornley, S., Veatupu, L., & Lang, B. (2022). If soft drink companies can do it, why can't government? Sugary drink sales policies in schools must be tightened. Australian and New Zealand journal of public health, 46(3), 415–416. https://doi.org/10.1111/1753-6405.13218
Baxter, C. (2010). Stockley's drug interactions. Pharmaceutical Press
Goldfrank, L. R., & Hoffman, R. S. (2006). Goldfrank's toxicologic emergencies (Vol. 831). McGraw-Hill
Yartsev, A., & Peisah, C. (2021). Caffeine-clozapine interaction associated with severe toxicity and multiorgan system failure: a case report. BMC psychiatry, 21(1), 192. https://doi.org/10.1186/s12888-021-03199-x
Drug Interactions Checker. (accessed on 19 October 2025). Available online: www.drugs.com/drug_interactions.html
Shi, X., Xue, W., Liang, S., Zhao, J., & Zhang, X. (2016). Acute caffeine ingestion reduces insulin sensitivity in healthy subjects: a systematic review and meta-analysis. Nutrition journal, 15(1), 103. https://doi.org/10.1186/s12937-016-0220-7
Posadzki, P., Watson, L., & Ernst, E. (2013). Herb-drug interactions: an overview of systematic reviews. British journal of clinical pharmacology, 75(3), 603–618. https://doi.org/10.1111/j.1365-2125.2012.04350.x
Diamond, B. J., & Bailey, M. R. (2013). Ginkgo biloba: indications, mechanisms, and safety. The Psychiatric clinics of North America, 36(1), 73–83. https://doi.org/10.1016/j.psc.2012.12.006
Diamond, B. J., & Bailey, M. R. (2013). Ginkgo biloba: indications, mechanisms, and safety. The Psychiatric clinics of North America, 36(1), 73–83. https://doi.org/10.1016/j.psc.2012.12.006
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