THE IMPACT OF PARTICULAR CHEMICALS IN CLOTHING ON HUMAN HEALTH — SUMMARY OF RECENT FINDINGS
Abstract
Recent studies clearly indicate that textile contamination with hazardous chemicals increasingly poses an emerging public health concern. Beyond its significant environmental implications, such contamination may lead to a variety of adverse health effects, including allergic skin reactions and an increased risk of autoimmune, metabolic, and oncological diseases. This comprehensive review highlights key chemical groups of concern frequently found in textiles that come into direct and prolonged contact with the skin, including heavy metals, per- and polyfluoroalkyl substances (PFAS), phthalates, and bisphenols. Their concentration in textiles, potential for bioaccumulation, and associated toxicological effects are concisely discussed in the context of human exposure and overall health risk. The following review synthesizes secondary data extracted from environmental studies, systematic reviews and meta-analyses obtained from PubMed between 2017 and 2025. The primary aim of this review is to present the current state of knowledge regarding the amounts, associated risks, and potential health effects of these chemicals.
References
Key L. (2024). Here's the Rub: Skin Care Products and Children's Phthalate Exposures. Environmental health perspectives, 132(12), 124002. https://doi.org/10.1289/EHP16068
Guo, Z., Cheng, Y., Zhu, L., et al. (2024). Dermal exposure to alkylphenol ethoxylates in as-purchased garments: Human health risk assessment. AATCC Journal of Research, 11(6), 456–463. https://doi.org/10.1177/24723444241275987
Ji, X., Liu, J., Shen, J., Su, P., Liang, J., Feng, X., Liu, X., & Liu, R. (2024). Characterization of chemical additives in daily clothing regarding human exposure and environmental emissions. Environmental Science & Technology Letters, 11(6), 619–625. https://doi.org/10.1021/acs.estlett.4c00297
Lavalle, R., Agnello, M., Mua, R., Fontana, M., Cravello, B., Piu, M., Panico, F., Cresti, R., Marcello, I., Attias, L., Ferranti, C., Palleschi, L., Baldassarri, L., Draisci, R., & Famele, M. (2025). Unveiling the Chemical Safety of Clothing Articles, Textiles and Footwear With Regard to the Presence of Carcinogenic, Mutagenic, or Reprotoxic Substances, Endocrine Disruptors and Skin Sensitizers Under EU Regulatory Restrictions. Contact dermatitis, 10.1111/cod.70026. Advance online publication. https://doi.org/10.1111/cod.70026
Rovira, J., Souza, M. C. O., Nadal, M., & Domingo, J. L. (2025). Human health risks from textile chemicals: a critical review of recent evidence (2019-2025). Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering, 60(2), 79–91. https://doi.org/10.1080/10934529.2025.2514406
Nguyen, T., & Saleh, M. A. (2017). Exposure of women to trace elements through the skin by direct contact with underwear clothing. Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering, 52(1), 1–6. https://doi.org/10.1080/10934529.2016.1221212
Zuo, C., Li, Y., Chen, Y., Jiang, J., Qiu, W., & Chen, Q. (2024). Leaching of heavy metals from polyester microplastic fibers and the potential risks in simulated real-world scenarios. Journal of hazardous materials, 461, 132639. https://doi.org/10.1016/j.jhazmat.2023.132639
Herrero, M., Rovira, J., González, N., Marquès, M., Barbosa, F., Sierra, J., Domingo, J. L., Nadal, M., & Souza, M. C. O. (2023). Clothing as a potential exposure source of trace elements during early life. Environmental research, 233, 116479. https://doi.org/10.1016/j.envres.2023.116479
Chen, H., Cheng, J., Li, Y., Li, Y., Wang, J., & Tang, Z. (2023). Occurrence and potential release of heavy metals in female underwear manufactured in China: Implication for women's health. Chemosphere, 342, 140165. https://doi.org/10.1016/j.chemosphere.2023.140165
Chen, H., Chai, M., Cheng, J., Wang, Y., & Tang, Z. (2022). Occurrence and health implications of heavy metals in preschool children's clothing manufactured in four Asian regions. Ecotoxicology and environmental safety, 245, 114121. https://doi.org/10.1016/j.ecoenv.2022.114121
Herrero, M., Rovira, J., Esplugas, R., Nadal, M., & Domingo, J. L. (2020). Human exposure to trace elements, aromatic amines and formaldehyde in swimsuits: Assessment of the health risks. Environmental research, 181, 108951. https://doi.org/10.1016/j.envres.2019.108951
Xiong, M., Cui, D., Cheng, Y., Ma, Z., Liu, C., Yan, C., Li, L., & Xiang, P. (2025). Heavy Metals in Infant Clothing: Assessing Dermal Exposure Risks and Pathways for Sustainable Textile Policies. Toxics, 13(8), 622. https://doi.org/10.3390/toxics13080622
Salami, E. A., & Rotimi, O. A. (2024). The impact of Bisphenol-A on human reproductive health. Toxicology reports, 13, 101773. https://doi.org/10.1016/j.toxrep.2024.101773
Ryu, D. Y., Pang, W. K., Adegoke, E. O., Rahman, M. S., Park, Y. J., & Pang, M. G. (2023). Bisphenol-A disturbs hormonal levels and testis mitochondrial activity, reducing male fertility. Human reproduction open, 2023(4), hoad044. https://doi.org/10.1093/hropen/hoad044
Trela-Kobędza, E., & Ajduk, A. (2025). The impact of bisphenol A and its analogs on female reproductive health. Reproductive biology, 25(3), 101028. https://doi.org/10.1016/j.repbio.2025.101028
Lazurova, Z., Lazurova, I., & Shoenfeld, Y. (2022). Bisphenol A as a Factor in the Mosaic of Autoimmunity. Endocrine, metabolic & immune disorders drug targets, 22(7), 728–737. https://doi.org/10.2174/1871530321666210516000042
Kim, K. Y., Lee, E., & Kim, Y. (2019). The Association between Bisphenol A Exposure and Obesity in Children-A Systematic Review with Meta-Analysis. International journal of environmental research and public health, 16(14), 2521. https://doi.org/10.3390/ijerph16142521
Wu, W., Li, M., Liu, A., Wu, C., Li, D., Deng, Q., Zhang, B., Du, J., Gao, X., & Hong, Y. (2020). Bisphenol A and the Risk of Obesity a Systematic Review With Meta-Analysis of the Epidemiological Evidence. Dose-response : a publication of International Hormesis Society, 18(2), 1559325820916949. https://doi.org/10.1177/1559325820916949
Hyun, S. A., & Ka, M. (2024). Bisphenol A (BPA) and neurological disorders: An overview. The international journal of biochemistry & cell biology, 173, 106614. https://doi.org/10.1016/j.biocel.2024.106614
Khan, N. G., Correia, J., Adiga, D., Rai, P. S., Dsouza, H. S., Chakrabarty, S., & Kabekkodu, S. P. (2021). A comprehensive review on the carcinogenic potential of bisphenol A: clues and evidence. Environmental science and pollution research international, 28(16), 19643–19663. https://doi.org/10.1007/s11356-021-13071-w
Wang, S., Lang, H., Cheng, J., Ma, J., Wang, J., & Tang, Z. (2025). Bisphenol compounds in female underwear manufactured in China and their potential risks to women's health. Journal of hazardous materials, 491, 137934. https://doi.org/10.1016/j.jhazmat.2025.137934
Jurikova, M., Dvorakova, D., Bechynska, K., & Pulkrabova, J. (2024). Bisphenols in daily clothes from conventional and recycled material: evaluation of dermal exposure to potentially toxic substances. Environmental science and pollution research international, 31(43), 55663–55675. https://doi.org/10.1007/s11356-024-34904-4
van der Veen, I., Hanning, A. C., Stare, A., Leonards, P. E. G., de Boer, J., & Weiss, J. M. (2020). The effect of weathering on per- and polyfluoroalkyl substances (PFASs) from durable water repellent (DWR) clothing. Chemosphere, 249, 126100. https://doi.org/10.1016/j.chemosphere.2020.126100
Zhao, X., Han, Y., Fu, M., Zhou, S., Yang, Y., Zhang, W., Peng, C., Zhang, W., Li, Q., Zhu, Q., & Yang, J. (2025). In vitro assessment of dermal penetration and skin barrier impairment by per- and polyfluoroalkyl substances (PFASs) from consumer products. Environmental pollution (Barking, Essex : 1987), 385, 127049. Advance online publication. https://doi.org/10.1016/j.envpol.2025.127049
Rudzanova, B., Vlaanderen, J., Kalina, J., Piler, P., Zvonar, M., Klanova, J., Blaha, L., & Adamovsky, O. (2023). Impact of PFAS exposure on prevalence of immune-mediated diseases in adults in the Czech Republic. Environmental research, 229, 115969. https://doi.org/10.1016/j.envres.2023.115969
Du, X., Wu, Y., Tao, G., Xu, J., Du, Z., Wu, M., Gu, T., Xiong, J., Xiao, S., Wei, X., Ruan, Y., Xiao, P., Zhang, L., & Zheng, W. (2024). Association between PFAS exposure and thyroid health: A systematic review and meta-analysis for adolescents, pregnant women, adults and toxicological evidence. The Science of the total environment, 953, 175958.
Qiao, J. C., Li, Z. H., Ma, Y. B., Ma, H. Y., Zhang, M. Y., Zhang, X. J., & Hu, C. Y. (2024). Associations of per- and polyfluoroalkyl substances (PFAS) and their mixture with risk of rheumatoid arthritis in the U.S. adult population. Environmental health : a global access science source, 23(1), 38. https://doi.org/10.1186/s12940-024-01073-3
Zhang, Q., Zhang, M., & Zhao, C. (2024). Exposure to Per- and Polyfluoroalkyl Substances and Risk of Psoriasis: A Population-Based Study. Toxics, 12(11), 828. https://doi.org/10.3390/toxics12110828
Li, H. L., Ma, W. L., Liu, L. Y., Zhang, Z., Sverko, E., Zhang, Z. F., Song, W. W., Sun, Y., & Li, Y. F. (2019). Phthalates in infant cotton clothing: Occurrence and implications for human exposure. The Science of the total environment, 683, 109–115. https://doi.org/10.1016/j.scitotenv.2019.05.132
Tang, Z., Chai, M., Wang, Y., & Cheng, J. (2020). Phthalates in preschool children's clothing manufactured in seven Asian countries: Occurrence, profiles and potential health risks. Journal of hazardous materials, 387, 121681. https://doi.org/10.1016/j.jhazmat.2019.121681
Zhang, W., Zheng, N., Wang, S., Sun, S., An, Q., Li, X., Li, Z., Ji, Y., Li, Y., & Pan, J. (2023). Characteristics and health risks of population exposure to phthalates via the use of face towels. Journal of environmental sciences (China), 130, 1–13. https://doi.org/10.1016/j.jes.2022.10.016
Aldegunde-Louzao, N., Lolo-Aira, M., & Herrero-Latorre, C. (2024). Phthalate esters in clothing: A review. Environmental toxicology and pharmacology, 108, 104457. https://doi.org/10.1016/j.etap.2024.104457
Valenzuela-Leon, P., & Dobrinski, I. (2017). Exposure to phthalate esters induces an autophagic response in male germ cells. Environmental epigenetics, 3(3), dvx010. https://doi.org/10.1093/eep/dvx010
Copyright (c) 2025 Justyna Tasior, Karolina Kasprzak, Małgorzata Kuczek, Aleksandra Wiśniewska, Julia Marek, Mateusz Jasiński, Michał Szalach, Aleksandra Żywicka, Bartosz Burda

This work is licensed under a Creative Commons Attribution 4.0 International License.
All articles are published in open-access and licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0). Hence, authors retain copyright to the content of the articles.
CC BY 4.0 License allows content to be copied, adapted, displayed, distributed, re-published or otherwise re-used for any purpose including for adaptation and commercial use provided the content is attributed.

