THE FUTURE OF ORTHOPAEDIC SURGERY: INTEGRATING 3D PRINTING, AI, AND BIOPRINTING
Abstract
The integration of three-dimensional (3D) printing into orthopedic surgery has significantly influenced surgical planning, implant customization, and patient. outcomes. This review explores clinical applications and the future of 3D printing, bioprinting, artificial intelligence (AI), and future 4D printing technologies in orthopedics. The use of 3D-printed anatomical models and patient-specific surgical guides has been shown to reduce operative time, intraoperative blood loss, and radiation .exposure, while improving implant fit and. surgical precision. Custom-made implants offer individual solutions for reconstructions, especially in cases of severe bone loss and musculoskeletal oncology. Emerging innovations such as AI-assisted design and bioprinted scaffolds further enhance treatment strategies. Additionally, 4D printing.introduces smart implants capable of adapting to physiology, opening new possibilities orthopedic problems. Despite challenges related to cost and production time ongoing technological progress is paving the way for wider clinical adoption.
References
Morgan C, Khatri C, Hanna SA, et al. Use of 3D Printing in Orthopedic Surgery: A Systematic Review and Meta-Analysis. BMJ Open, 2020; 10(10): e034500. https://pubmed.ncbi.nlm.nih.gov/31966970/
Tack P, Victor J, Gemmel P, Annemans L. 3D-printing techniques in orthopedic surgery: an overview. EFORT Open Rev, 2016; 1(5), 133-142. https://pmc.ncbi.nlm.nih.gov/articles/PMC5073919/
Filip DF, Snela S, Przeszłowski Ł, Łazorko A, Dziura W. Extensive type IIIB bone loss of the acetabulum and suitability of 3D printings during planning. J Pre-Clin Clin Res, 2021; 15(2): 63–67. https://agro.icm.edu.pl/agro/element/bwmeta1.element.agro-eb638c60-b417-424e-9e9b-5c58f549b0e7/c/63-67.pdf
Robinson, J., & Robinson, R. 3D printing in total knee arthroplasty: a review of current status and future applications. Orthopedic Reviews, 2021; 13(2): 249-257. https://pmc.ncbi.nlm.nih.gov/articles/PMC8149509/
Philip Tack, Jan Victor, Paul Gemmel and Lieven Annemans 3D-printing techniques in a medical setting: a systematic literature review https://pmc.ncbi.nlm.nih.gov/articles/PMC5073919/pdf/12938_2016_Article_236.pdf
Prasoon Kumar, Pulak Vatsya, Rajesh Kumar Rajnish, Aman Hooda, Mandeep S. Dhillon Application of 3D Printing in Hip and Knee Arthroplasty: A Narrative Review https://pmc.ncbi.nlm.nih.gov/ articles/PMC8149509/pdf/43465_2020_Article_263.pdf
Cabarcas, B. C., Cvetanovich, G. L., Gowd, A. K., et al. Accuracy of Patient-Specific 3-DimensionalPrinted Glenoid Guides for Shoulder Arthroplasty. Orthop J Sports Med, 2019; 7(11): 2325967119882190. https://pubmed.ncbi.nlm.nih.gov/31334434/
Lal, H., Patralekh, M.K. 3D printing and its applications in orthopaedic trauma: A technological marvel. J Clin Orthop Trauma, 2018; 9(3), 260-268. https://pubmed.ncbi.nlm.nih.gov/30202159/
Andre F. Steinert, Lennart Schröder, Lukas Sefrin, Björn Janßen, Jörg Arnholdt, Maximilian Rudert The Impact of Total Knee Replacement with a Customized Cruciate-Retaining Implant Design on Patient-Reported and Functional Outcomes https://pmc.ncbi.nlm.nih.gov/articles/PMC8880382/
Angelini, A., Kotrych, D., Trovarelli, G., Szafrański, A., Bohatyrewicz, A., & Ruggieri, P. Current role of 3D printing in musculoskeletal oncology. Expert Rev Med Devices, 2020; 17(8), 583–594. https://pubmed.ncbi.nlm.nih.gov/37158428/
Javaid M, Haleem A. Additive manufacturing applications in orthopaedics: A review. J Clin Orthop Trauma, 2019; 10(2), 380-386. https://pubmed.ncbi.nlm.nih.gov/30202149/
Bose S, Ke D, Sahasrabudhe H, Bandyopadhyay A. Additive manufacturing of biomaterials for orthopedic implants: A review. Acta Biomater, 2018; 93, 3-18. https://pubmed.ncbi.nlm.nih.gov/31406390/
Ventola CL. Medical Applications for 3D Printing: Current and Projected Uses. P T. 2014 Oct;39(10):704-11. PMID: 25336867; PMCID: PMC4189697. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4189697/
Ioannis G Trikoupis, Ioannis I Mavrodontis, Dimitrios V Papadopoulos, Stavros D Goumenos, Dimitrios A Georgoulis, Panagiotis Gavriil, Dimitra Melissaridou, Olga D Savvidou, Vasileios A Kontogeorgakos, Panayiotis J Papagelopoulos 3D-printed glenoid implant reconstruction, after partial scapulectomy for malignant tumors: a case series https://pubmed.ncbi.nlm.nih.gov/38280074/
Martelli N, Serrano C, van den Brink H, et al. Advantages and Disadvantages of 3-Dimensional Printing in Surgery: A Systematic Review. Surgery. 2016 Oct;159(6):1485-1500. doi: 10.1016/ j.surg.2015.12.017. Epub 2016 Feb 25. PMID: 26969539. https://www.researchgate.net/publication/292386470_Advantages_and_disadvantages_of_3dimensional_printing_in_surgery_A_systematic_review
Javed Iqbal, Zaitoon Zafar, Georgios Skandalakis, Venkataramana Kuruba, Shreya Madan, Syed Faraz Kazim, Christian A Bowers Recent advances of 3D-printing in spine surgery https://pubmed.ncbi.nlm.nih.gov/39246777/
Yikai Liu, Zian Zhang, Wenzhe Wang, Chaoqun Yu, Chang Liu, Zhenchao Huang, Kaige Xu, Haining Zhang Artificial intelligence planning and 3D printing augmented modules in the treatment of a complicated hip joint revision: a case report https://pubmed.ncbi.nlm.nih.gov/37795146/
Benjamin Hajnal, Agoston Jakab Pokorni, Mate Turbucz, Ferenc Bereczki, Marton Bartos, Aron Lazary, Peter Endre Eltes Clinical applications of 3D printing in spine surgery: a systematic review https://pubmed.ncbi.nlm.nih.gov/39774918/
Zhaolong Li, Qinghai Wang, Guangdong Liu A Review of 3D Printed Bone Implants https://pmc.ncbi.nlm.nih.gov/articles/PMC9025296/
Cambre Kelly, Samuel B Adams Jr 3D Printing Materials and Technologies for Orthopaedic Applicationshttps://pubmed.ncbi.nlm.nih.gov/38502597/
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