QUERCETIN, LACTOBACILLUS, VITAMIN D3 – THE GOLDEN THREE THAT WILL HELP YOU WITH YOUR ALLERGY PROBLEMS

Barbara Pękowska; Adrianna Brzozowska; Karolina Niewczas; Katarzyna Kozon; Anna Bielicka; Hubert Bochenek; Irmina Czerepak; Julia Gugulska; Michał Bzoma; Karolina Jaros; Adam Niedziela; Dominik Domoń

doi:10.31435/ijitss.3(47).2025.3541

Barbara Pękowska Faculty of Medicine, Kazimierz Pułaski University of Technology and Humanities in Radom: Radom, Poland https://orcid.org/0009-0001-1258-2867
Adrianna Brzozowska Mazowiecki Szpital Bródnowski, ul. Kondratowicza 8, 03-242 Warsaw, Poland. Faculty of Medicine, Medical University of Warsaw, Żwirki i Wigury 61, 02-091 Warsaw, Poland https://orcid.org/0009-0009-2625-4766
Karolina Niewczas Faculty of Medicine, Medical University of Warsaw, Żwirki i Wigury 61, 02-091 Warsaw, Poland https://orcid.org/0009-0009-5007-0123
Katarzyna Kozon Mazowiecki Szpital Bródnowski, ul. Kondratowicza 8, 03-242 Warsaw, Poland. Faculty of Medicine, Medical University of Warsaw, Żwirki i Wigury 61, 02-091 Warsaw, Poland https://orcid.org/0009-0009-6536-946X
Anna Bielicka Non-public Health Care Facility “Dekamed”, Lipińska 99, 05-200 Wołomin, Poland. Faculty of Medicine, Medical University of Warsaw, Żwirki i Wigury 61, 02-091 Warsaw, Poland https://orcid.org/0009-0002-3461-4812
Hubert Bochenek Faculty of Medicine, Medical University of Warsaw, Żwirki i Wigury 61, 02-091 Warsaw, Poland https://orcid.org/0009-0002-7221-2793
Irmina Czerepak Faculty of Medicine, Medical University of Warsaw, Żwirki i Wigury 61, 02-091 Warsaw, Poland https://orcid.org/0009-0009-9964-3439
Julia Gugulska Faculty of Medicine, Medical University of Warsaw, Żwirki i Wigury 61, 02-091 Warsaw, Poland https://orcid.org/0009-0007-8333-5066
Michał Bzoma Faculty of Medicine, Medical University of Warsaw, Żwirki i Wigury 61, 02-091 Warsaw, Poland https://orcid.org/0009-0008-9165-8735
Karolina Jaros Faculty of Medicine, Medical University of Warsaw, Żwirki i Wigury 61, 02-091 Warsaw, Poland https://orcid.org/0009-0006-2573-1389
Adam Niedziela Medical University of Warsaw, Żwirki i Wigury 61, 02-091 Warsaw, Poland https://orcid.org/0009-0002-6178-6484
Dominik Domoń Medical University of Warsaw, Żwirki i Wigury 61, 02-091 Warsaw, Poland https://orcid.org/0009-0008-7631-4563

DOI: https://doi.org/10.31435/ijitss.3(47).2025.3541

Keywords: Asthma, Atopic dermatitis, Allergic Rhinitis, Immunomodulation, Epithelial Barrier, Adjunctive Therapy

Abstract

Objective: Allergic diseases, including asthma, atopic dermatitis (AD) and allergic rhinitis (AR), are increasingly prevalent and significantly impact quality of life. These conditions are driven by an overactive Th2 immune response, leading to chronic inflammation. There is growing interest in novel therapies, such as quercetin, Lactobacillus species and vitamin D₃, which exhibit immunomodulatory properties and could offer new therapeutic strategies for managing allergic diseases.

Methods: This review explores the role of quercetin, Lactobacillus spp. and vitamin D₃ in modulating immune responses associated with asthma, atopic dermatitis and allergic rhinitis. We examined current literature on their mechanisms of action, effects on immune modulation and clinical evidence supporting their use in allergic conditions.

Key findings: Quercetin demonstrated anti-inflammatory, antioxidant, and immunomodulatory effects, reducing Th2 cytokine production and mitigating inflammation in asthma, atopic dermatitis and allergic rhinitis. Lactobacillus species, especially L. rhamnosus and L. plantarum, promoted immune tolerance by enhancing regulatory T cell activity and improving gut barrier integrity. Vitamin D₃, through its active form calcitriol, attenuated Th2-driven inflammation, strengthened epithelial barriers, and improved clinical outcomes in asthma, atopic dermatitis and allergic rhinitis.

Conclusions: Quercetin, Lactobacillus spp. and vitamin D₃ show promising potential as adjunctive therapies in allergic diseases. These interventions modulate key immune pathways, reduce inflammation and restore immune balance. However, further research is needed to establish optimal dosages and treatment regimens.

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QUERCETIN, LACTOBACILLUS, VITAMIN D3 – THE GOLDEN THREE THAT WILL HELP YOU WITH YOUR ALLERGY PROBLEMS

Abstract

References

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