RESTLESS LEG SYNDROME AS A REASON OF CHRONIC INSOMNIA
Abstract
Restless legs syndrome (RLS) is characterized by discomfort in the lower limbs with a strong need to move to bring relief. Based on the available literature and numerous studies on patient groups, we decided to summaries the aetiologias, risk factors, epidemiologies, and treatments for RLS. It is one of the most common causes of insomnia in both adult and child populations. Particularly at risk of developing RLS are people suffering from chronic renal failure, and pregnant women. Causes of RSL include mainly iron deficiency, and disturbances in dopaminergic transmission. Diagnosis is made primarily on the basis of the presence of symptoms, their severity, and frequency. Treatment first recommends non-pharmacological methods in the form of warm baths, massages, relaxation exercises, and avoidance of triggers. At a later stage, patients with more intractable symptoms are treated with oral iron supplementation, dopaminergic agonists, and alpha-2-delta ligands.
References
Gossard, T. R., Trotti, L. M., Videnovic, A., & St Louis, E. K. (2021). Restless Legs Syndrome: Contemporary Diagnosis and Treatment. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 18(1), 140–155. https://doi.org/10.1007/s13311-021-01019-4
Silber, M. H., Buchfuhrer, M. J., Earley, C. J., Koo, B. B., Manconi, M., Winkelman, J. W., & Scientific and Medical Advisory Board of the Restless Legs Syndrome Foundation (2021). The Management of Restless Legs Syndrome: An Updated Algorithm. Mayo Clinic proceedings, 96(7), 1921–1937. https://doi.org/10.1016/j.mayocp.2020.12.026
Silvestri, R., & DelRosso, L. M. (2021). Pediatric Restless Legs Syndrome. Sleep medicine clinics, 16(2), 305–314. https://doi.org/10.1016/j.jsmc.2021.02.006
Allen, R. P., Picchietti, D. L., Garcia-Borreguero, D., Ondo, W. G., Walters, A. S., Winkelman, J. W., Zucconi, M., Ferri, R., Trenkwalder, C., Lee, H. B., & International Restless Legs Syndrome Study Group (2014). Restless legs syndrome/Willis-Ekbom disease diagnostic criteria: updated International Restless Legs Syndrome Study Group (IRLSSG) consensus criteria--history, rationale, description, and significance. Sleep medicine, 15(8), 860–873. https://doi.org/10.1016/j.sleep.2014.03.025
Li, Y. S., Yeh, W. C., & Hsu, C. Y. (2023). Association of low serum ferritin levels with augmentation in patients with restless legs syndrome: A systematic review and meta-analysis. Sleep medicine, 112, 173–180. https://doi.org/10.1016/j.sleep.2023.10.022
Safarpour, Y., Vaziri, N. D., & Jabbari, B. (2023). Restless Legs Syndrome in Chronic Kidney Disease- a Systematic Review. Tremor and other hyperkinetic movements (New York, N.Y.), 13, 10. https://doi.org/10.5334/tohm.752
Szentkiralyi, A., Molnar, M. Z., Czira, M. E., Deak, G., Lindner, A. V., Szeifert, L., Torzsa, P., Vamos, E. P., Zoller, R., Mucsi, I., & Novak, M. (2009). Association between restless legs syndrome and depression in patients with chronic kidney disease. Journal of psychosomatic research, 67(2), 173–180. https://doi.org/10.1016/j.jpsychores.2009.05.004
Winkelmann, J., Stautner, A., Samtleben, W., & Trenkwalder, C. (2002). Long-term course of restless legs syndrome in dialysis patients after kidney transplantation. Movement disorders : official journal of the Movement Disorder Society, 17(5), 1072–1076. https://doi.org/10.1002/mds.10231
Azar, S. A., Hatefi, R., & Talebi, M. (2007). Evaluation of effect of renal transplantation in treatment of restless legs syndrome. Transplantation proceedings, 39(4), 1132–1133. https://doi.org/10.1016/j.transproceed.2007.03.097
Grover, A., Clark-Bilodeau, C., & D'Ambrosio, C. M. (2015). Restless leg syndrome in pregnancy. Obstetric medicine, 8(3), 121–125. https://doi.org/10.1177/1753495X15587452
Nowakowski, S., & Meers, J. M. (2019). Cognitive Behavioral Therapy for Insomnia and Women's Health: Sex as a Biological Variable. Sleep medicine clinics, 14(2), 185–197. https://doi.org/10.1016/j.jsmc.2019.01.002
Tuna Oran, N., Yuksel, E., & Ruzgar, S. (2021). Prevalence of restless leg syndrome and effects on quality of life during pregnancy. Sleep & breathing = Schlaf & Atmung, 25(4), 2127–2134. https://doi.org/10.1007/s11325-021-02311-5
Liang, R., Zhu, W., Gao, Y., Zhao, C., Zhang, C., Xu, L., Zuo, Y., Lv, Y., Zhao, M., Li, C., Gao, J., Mei, J., Gong, X., Zhang, L., Shen, S., Yang, C., Ren, J., Liu, Y., Wang, Z., Wang, P., … Han, F. (2024). Clinical features, polysomnography, and genetics association study of restless legs syndrome in clinic based Chinese patients: A multicenter observational study. Sleep medicine, 117, 123–130. https://doi.org/10.1016/j.sleep.2024.03.022
Becker P. M. (2015). Diagnosis of Restless Leg Syndrome (Willis-Ekbom Disease). Sleep medicine clinics, 10(3), 235–xii. https://doi.org/10.1016/j.jsmc.2015.05.001
Woo, H. G., Lee, D., Hwang, K. J., & Ahn, T. B. (2017). Post-stroke restless leg syndrome and periodic limb movements in sleep. Acta neurologica Scandinavica, 135(2), 204–210. https://doi.org/10.1111/ane.12582
During, E. H., & Winkelman, J. W. (2019). Drug Treatment of Restless Legs Syndrome in Older Adults. Drugs & aging, 36(10), 939–946. https://doi.org/10.1007/s40266-019-00698-1
Vlasie, A., Trifu, S. C., Lupuleac, C., Kohn, B., & Cristea, M. B. (2022). Restless legs syndrome: An overview of pathophysiology, comorbidities and therapeutic approaches (Review). Experimental and therapeutic medicine, 23(2), 185. https://doi.org/10.3892/etm.2021.11108
Klingelhoefer, L., Bhattacharya, K., & Reichmann, H. (2016). Restless legs syndrome. Clinical medicine (London, England), 16(4), 379–382. https://doi.org/10.7861/clinmedicine.16-4-379
Marshall, N. S., Serinel, Y., Killick, R., Child, J. M., Raisin, I., Berry, C. M., Lallukka, T., Wassing, R., Lee, R. W., Ratnavadivel, R., Vedam, H., Grunstein, R., Wong, K. K., Hoyos, C. M., Cayanan, E. A., Comas, M., Chapman, J. L., & Yee, B. J. (2019). Magnesium supplementation for the treatment of restless legs syndrome and periodic limb movement disorder: A systematic review. Sleep medicine reviews, 48, 101218. https://doi.org/10.1016/j.smrv.2019.101218
Comella C. L. (2014). Treatment of restless legs syndrome. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 11(1), 177–187. https://doi.org/10.1007/s13311-013-0247-9
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Copyright (c) 2024 Jakub Jędrychowski, Natalia Pacocha, Natalia Karpowicz, Julia Kaszucka, Justyna Popczyńska, Agnieszka Raczyńska, Małgorzata Krzyżanowska, Marta Zgierska, Kinga Kosiec, Oliwia Krzemień
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