OMEGA-3 FATTY ACID SUPPLEMENTATION FOR ATTENTION DEFICIT HYPERACTIVITY DISORDER IN CHILDREN AND ADOLESCENT: LITERATURE REVIEW
Abstract
Introduction and objective:
Attention Deficit Hyperactivity Disorder affects 5.29% globally, with rising incidence, particularly in boys. The eleventh revision of the International Classification of Diseases defines ADHD by persistent patterns of inattention and/or hyperactivity-impulsivity. Stimulants (such as methylphenidate) and atomoxetine are effective but carry side effects. Omega-3 fatty acids show promise in influencing synaptic membrane structure and neurotransmitter activity. Studies suggest benefits for ADHD symptoms, making Omega-3 supplementation a potential adjunctive treatment.
Review methods:
PubMed database was used for the review. An electronic search was performed within publication years (2005–2024) using English search phrases such as "ADHD," "ADHD treatment," "Omega-3 supplementation," and "polyunsaturated fatty acids in ADHD." All retrieved articles, including original and randomized controlled studies, were analyzed.
Results:
The average Omega-3 intake in the U.S. falls below recommended levels. Western diets' Omega-6 dominance may exacerbate inflammation, while Omega-3 deficiencies could impact ADHD symptoms. Studies suggest Omega-3 supplementation may reduce impulsivity and improve attention. A Mexican trial found comparable efficacy between Omega-3/6 and methylphenidate (MPH). However, a French trial favored a placebo. Recent Italian research found limited benefits in mild ADHD cases.
Conclusions:
As ADHD rates rise, more research is needed to manage the disorder. Omega-3 supplementation shows mixed results in improving symptoms, highlighting the need for further investigation. For a final determination of this impact, it seems necessary to conduct studies with a long observation period, in which various doses and combinations of Omega-3 acids will be considered, as well as retrospective studies.
References
Abdullah, M., Jowett, B., Whittaker, P. J., & Patterson, L. (2019). The effectiveness of omega-3 supplementation in reducing ADHD associated symptoms in children as measured by the Conners' rating scales: A systematic review of randomized controlled trials. J Psychiatr Res, 110, 64-73. https://doi.org/10.1016/j.jpsychires.2018.12.002
Barragán, E., Breuer, D., & Döpfner, M. (2017). Efficacy and Safety of Omega-3/6 Fatty Acids, Methylphenidate, and a Combined Treatment in Children With ADHD. J Atten Disord, 21(5), 433-441. https://doi.org/10.1177/1087054713518239
Bloch, M. H., & Mulqueen, J. (2014). Nutritional supplements for the treatment of ADHD. Child Adolesc Psychiatr Clin N Am, 23(4), 883-897. https://doi.org/10.1016/j.chc.2014.05.002
Bos, D. J., Oranje, B., Veerhoek, E. S., Van Diepen, R. M., Weusten, J. M., Demmelmair, H., Koletzko, B., de Sain-van der Velden, M. G., Eilander, A., Hoeksma, M., & Durston, S. (2015). Reduced Symptoms of Inattention after Dietary Omega-3 Fatty Acid Supplementation in Boys with and without Attention Deficit/Hyperactivity Disorder. Neuropsychopharmacology, 40(10), 2298-2306. https://doi.org/10.1038/npp.2015.73
Bozzatello, P., Brignolo, E., De Grandi, E., & Bellino, S. (2016). Supplementation with Omega-3 Fatty Acids in Psychiatric Disorders: A Review of Literature Data. J Clin Med, 5(8). https://doi.org/10.3390/jcm5080067
Carucci, S., Romaniello, R., Demuru, G., Curatolo, P., Grelloni, C., Masi, G., Liboni, F., Mereu, A., Contu, P., Lamberti, M., Gagliano, A., & Zuddas, A. (2022). Omega-3/6 supplementation for mild to moderate inattentive ADHD: a randomised, double-blind, placebo-controlled efficacy study in Italian children. Eur Arch Psychiatry Clin Neurosci, 272(8), 1453-1467. https://doi.org/10.1007/s00406-022-01428-2
Chang, J. P., Su, K. P., Mondelli, V., & Pariante, C. M. (2018). Omega-3 Polyunsaturated Fatty Acids in Youths with Attention Deficit Hyperactivity Disorder: a Systematic Review and Meta-Analysis of Clinical Trials and Biological Studies. Neuropsychopharmacology, 43(3), 534-545. https://doi.org/10.1038/npp.2017.160
Cholewski, M., Tomczykowa, M., & Tomczyk, M. (2018). A Comprehensive Review of Chemistry, Sources and Bioavailability of Omega-3 Fatty Acids. Nutrients, 10(11). https://doi.org/10.3390/nu10111662
Cornu, C., Mercier, C., Ginhoux, T., Masson, S., Mouchet, J., Nony, P., Kassai, B., Laudy, V., Berquin, P., Franc, N., Le Heuzey, M. F., Desombre, H., & Revol, O. (2018). A double-blind placebo-controlled randomised trial of omega-3 supplementation in children with moderate ADHD symptoms. Eur Child Adolesc Psychiatry, 27(3), 377-384. https://doi.org/10.1007/s00787-017-1058-z
Cortese, S., Holtmann, M., Banaschewski, T., Buitelaar, J., Coghill, D., Danckaerts, M., Dittmann, R. W., Graham, J., Taylor, E., & Sergeant, J. (2013). Practitioner review: current best practice in the management of adverse events during treatment with ADHD medications in children and adolescents. J Child Psychol Psychiatry, 54(3), 227-246. https://doi.org/10.1111/jcpp.12036
Culpepper, L., & Mattingly, G. (2010). Challenges in identifying and managing attention-deficit/hyperactivity disorder in adults in the primary care setting: a review of the literature. Prim Care Companion J Clin Psychiatry, 12(6). https://doi.org/10.4088/PCC.10r00951pur
Dark, C., Homman-Ludiye, J., & Bryson-Richardson, R. J. (2018). The role of ADHD associated genes in neurodevelopment. Dev Biol, 438(2), 69-83. https://doi.org/10.1016/j.ydbio.2018.03.023
Decandia, D., Landolfo, E., Sacchetti, S., Gelfo, F., Petrosini, L., & Cutuli, D. (2022). n-3 PUFA Improve Emotion and Cognition during Menopause: A Systematic Review. Nutrients, 14(9). https://doi.org/10.3390/nu14091982
Döpfner, M., Dose, C., Breuer, D., Heintz, S., Schiffhauer, S., & Banaschewski, T. (2021). Efficacy of Omega-3/Omega-6 Fatty Acids in Preschool Children at Risk of ADHD: A Randomized Placebo-Controlled Trial. J Atten Disord, 25(8), 1096-1106. https://doi.org/10.1177/1087054719883023
Drechsler, R., Brem, S., Brandeis, D., Grünblatt, E., Berger, G., & Walitza, S. (2020). ADHD: Current Concepts and Treatments in Children and Adolescents. Neuropediatrics, 51(5), 315-335. https://doi.org/10.1055/s-0040-1701658
Faraone, S. V., Perlis, R. H., Doyle, A. E., Smoller, J. W., Goralnick, J. J., Holmgren, M. A., & Sklar, P. (2005). Molecular genetics of attention-deficit/hyperactivity disorder. Biol Psychiatry, 57(11), 1313-1323. https://doi.org/10.1016/j.biopsych.2004.11.024
Katzman, M. A., Bilkey, T. S., Chokka, P. R., Fallu, A., & Klassen, L. J. (2017). Adult ADHD and comorbid disorders: clinical implications of a dimensional approach. BMC Psychiatry, 17(1), 302. https://doi.org/10.1186/s12888-017-1463-3
Organization, W. H. (2021). International Statistical Classification of Diseases and Related Health Problems (11th ed,; ICD-11). Retrieved April 20, 2024 from https://icd.who.int/browse/2024-01/mms/en#821852937
Polanczyk, G., de Lima, M. S., Horta, B. L., Biederman, J., & Rohde, L. A. (2007). The worldwide prevalence of ADHD: a systematic review and metaregression analysis. Am J Psychiatry, 164(6), 942-948. https://doi.org/10.1176/ajp.2007.164.6.942
Posner, J., Polanczyk, G. V., & Sonuga-Barke, E. (2020). Attention-deficit hyperactivity disorder. Lancet, 395(10222), 450-462. https://doi.org/10.1016/s0140-6736(19)33004-1
San Mauro Martin, I., Sanz Rojo, S., González Cosano, L., Conty de la Campa, R., Garicano Vilar, E., & Blumenfeld Olivares, J. A. (2022). Impulsiveness in children with attention-deficit/hyperactivity disorder after an 8-week intervention with the Mediterranean diet and/or omega-3 fatty acids: a randomised clinical trial. Neurologia (Engl Ed), 37(7), 513-523. https://doi.org/10.1016/j.nrleng.2019.09.009
Sharma, A., & Couture, J. (2014). A review of the pathophysiology, etiology, and treatment of attention-deficit hyperactivity disorder (ADHD). Ann Pharmacother, 48(2), 209-225. https://doi.org/10.1177/1060028013510699
Thapar, A., & Cooper, M. (2016). Attention deficit hyperactivity disorder. Lancet, 387(10024), 1240-1250. https://doi.org/10.1016/s0140-6736(15)00238-x
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