ОСОБЛИВОСТІ МОРФОЛОГІЧНИХ КОМПОНЕНТІВ ХРЯЩОВОГО ПОКРИТТЯ КОЛІННОГО СУГЛОБА НА МІКРОСТРУКТУРНОМУ ТА УЛЬТРАСТРУКТУРНОМУ РІВНЯХ НАПРИКІНЦІ ДВОХТИЖНЕВОЇ ВІДМІНИ ЕКСПЕРИМЕНТАЛЬНОГО ОПІОЇДНОГО ВПЛИВУ
Abstract
The work, presented below, compares pathomorphological changes of the articular cartilage in the distal epiphysis of the femur and proximal epiphyses of the tibia at the end of the 56th day in rats after two - week opioid withdrawal at the micro- and ultrastructural levels. The goal was achieved by micro- and ultrastructural visualization of the components of the articular cartilage. Specimen preparation for electron and light microscopy was done according to the generally accepted methods.
The results of this study will form the basis for developing a comprehensive therapeutical approach in management of lesions of structural components of the articular cartilage in opioid chondrodystrophy.
References
Badokin, V. V. (2014). The role of inflammation in the development and course of osteoarthritis. Cjnsilium medicum, 1 (9), 91-95.
Brandt, K. D. (2000). Diagnosis and nonsurgical management of osteoarthritis. Oklahoma: Proffesional communications.
Arden, N., & Nevitt, M. C. (2006). Osteoarthrosis: epidemiology. Best Pract Res Clin Rheumatol, 20 (1), 3-25.
Jordan, K. M., Arden, N. K., Doherty, M., Bannwarth, B., Bijlsma, J.W., ..., & Dougados, M. (2003). EULAR Recommendations 2003: an evidence based approach to the management of knee osteoarthritis: Report of a Task Force of the Standing Committee for international Clinical Studies Including Therapeutic Trials (ESCISIT). Ann Rheum Dis, 62 (12), 1145-1155.
Romais, B. (1953). Microscopic technique. (p. 71-72). Moscow: Medicine.
Glauert, A. M. (1975). Fixatson, dehydration and embedding of biologicalspecimens. In: Glauert A. M. (Ed.), Practical methods in electron microscpi. North-Hollond: American Elsevier.
Stempak J.G., & Ward R.T. (1964). An improved staining method for electron microscopy. J Cell Biol, 22 (3), 697-701.
Reynolds E.S. (1963). The use of lead citrate at high pH as an electronopague stain in electron microscopy. J Cell Biol, 17, 208-212
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