World Science 2020-10-18T21:05:36+02:00 RS Global, Editorial office (journals department) Open Journal Systems <p style="line-height: 1.6;"><strong>Original articles</strong><br>p-ISSN: 2413-1032<br>e-ISSN: 2414-6404<br>DOI: 10.31435/rsglobal_ws<br>OCLC Number: 1051262033<br>Publisher - RS Global Sp. z O.O., Poland<br>Subject areas: engineering and medicine</p> SOFTWARE SELECTION ON BASE OF SUGENO INTEGRAL 2020-10-05T09:51:22+02:00 Vagif Salimov <p>The article is devoted to the problem of&nbsp; software selection. As a rule, this tasks are formalized as models of multi-criteria decision making (MCDM). The peculiarity of this problem is in the fact that the evaluation criteria , is generally defined by linguistic expert. This requires the use of special methods, in particularly, the theory of fuzzy sets. To solve the problem, an approach based on the&nbsp; a fuzzy measure&nbsp; was used . In general, a fuzzy measure allows one to take into account the effect of the mutual influence of criteria. The main difficulty lies in identifying this measure. The fuzzy Sugeno measure and &nbsp;Sugeno integral were used. An example of solving the indicated problem is given.</p> 2020-08-22T00:00:00+02:00 Copyright (c) 2020 Vagif Salimov RISK ASSESSMENT OF CARBONATE GAS FORMATION IN MANUAL ARC WELDING 2020-10-14T19:50:16+02:00 Березуцький В. В. Хондак І. І. <p>The risk analysis is performed of carbon monoxide formation during manual arc welding of metal products using electrodes. The system of protection is considered of the person against carbon monoxide in the room of manufacturing which consists of means of collective and individual protection. The reasons are analysed for failures of the workplace safety system. A failure tree was constructed of the welder's protection system against carbon monoxide using a protective mask, which is not equipped with a gas detector, and when working in a mask which is equipped with a gas detector. The mathematical models of welding processes are obtained as a result of research and analysis of the results. Mathematical expressions are given for calculating the reliability of the protection system. The risk assessment take the place for carbon monoxide poisoning during welding works with the system of ensuring the safety of the employee, i.e. the notification system for the presence of carbon monoxide in the work area (individual alarm) and without it.</p> 2020-08-23T00:00:00+02:00 Copyright (c) 2020 The authors FACTOR RESEARCH OF PRIME COST OF INTERNATIONAL ROAD TRANSPORTATION OF PARTY CARGO 2020-10-14T22:15:11+02:00 Ширяєва Світлана Володимирівна Свірін Дмитро Олександрович <div class="page" title="Page 2"> <div class="layoutArea"> <div class="column"> <p>One of the important tasks to be solved by carriers and freight forwarders in the organization of international road transportation of party cargoes is the choice of effective methods of cargo transportation. For this purpose it is expedient to estimate each method on criteria of efficiency of the international road transportations of party cargoes (time, financial, etc.). A very important financial criterion is the prime cost of 1 km of the vehicle mileage during the international road transportation of party cargoes. The influence of factors on it, such as: mileage of vehicles, operating costs for international road transportation of party goods, the volume of the consignment of goods transported. Factor analysis was performed by different methods: multiple regression, nonlinear multiple regression and neural networks. According to the results of research, we can conclude that the smallest balances in the prediction of neural networks, because they are self-improving and give a more accurate result.</p> </div> </div> </div> 2020-08-31T00:00:00+02:00 Copyright (c) 2020 The authors VERTICAL FARMS 2020-10-07T16:12:23+02:00 Veselin Rangelov Daniela Staykova <p>The urbanized population is increasing year by year, leaving fewer and fewer inhabitants in the province. This inevitably leads to increased energy and resource consumption, leading to environmental problems. All this, combined with climate change, calls for a more holistic approach to the provision of raw materials and resources in future cities, both in the main aspects of sustainable development, social, environmental and economic. From this point of view, vertical farms can be an instrument that addresses these aspects.</p> 2020-08-22T00:00:00+02:00 Copyright (c) 2020 USING OF THE METHOD OF RADIO-THERMAL IMAGING TECHNOLOGY FOR THE SEARCH FOR ORE DEPOSITS OF PLATINUM GROUP METALS, INCLUDING PALLADIUM 2020-10-14T10:37:03+02:00 Wladimir Shel Stepchenko Wladimir Nikolaevich Rodna Valentina Antonovna Bagryantsev Wladimir Anatolievich <p>The possibilities of the method of Radio-Thermal Imaging Technology for the search for ore deposits of platinum group metals, in particular - palladium, are considered on the example of the Elansky deposit of the Voronezh crystalline massif. Geothermal sections show a columnar geological structure (intrusion) of a main ore body containing palladium and other platinum group elements. The deep origin of ore deposits of platinoid-copper-nickel-palladium deposits, the connection of ore structures with dikes has been traced.</p> 2020-09-02T00:00:00+02:00 Copyright (c) 2020 Wladimir Shel, Stepchenko Wladimir Nikolaevich, Rodna Valentina Antonovna, Bagryantsev Wladimir Anatolievich SYNTHESIS OF NOVOLAC TYPE PHENOL FORMALDEHYDE OLIGOMERS 2020-10-16T08:46:09+02:00 Givi Papava Marina Gurgenishvili Ia Chitrekashvili Eter Gavashelidze Nora Dokhturishvili <div class="page" title="Page 2"> <div class="section"> <div class="layoutArea"> <div class="column"> <p>Mixed novolac-type oligomers are synthesized in the melt on the base of oxibenzene and its alkilsubstituted. The content of dioxibenzene changes in the range of 0,1 – 0,5 mol. The influence of temperature and duration of the reaction of initial components, transformation has been studied.</p> </div> </div> </div> </div> 2020-08-26T00:00:00+02:00 Copyright (c) 2020 The authors EPOXY POLYMERS BASED ON DIGLYCIDYL ETHERS WITH CYCLIC GROUPS 2020-10-16T08:58:16+02:00 Givi Papava Nora Dokhturishvili Marina Gurgenishvili Ia Chitrekashvili Zurab Chubinishvili <p>Glycidyl ethers of polycyclic bisphenols of norbornan type and their phenyl substituted derivatives were obtained and studied. They were solidified by diaminodiphenylsulphon and methyltetrahydrophthalic anhydride. The data of the termogravimetric analysis of the obtained polymers showed that they are characterizes by high thermal – and heat stability.<br>The properties of polymers depend on the structure of the hardener and its chemical nature as well. The properties of polymers were sharply changed when glycidyl derivatives of bisphenols were cured by hardeners of different chemical structure. The presence of cyclic structures in the hardener molecule causes considerable increase of their thermal stability. Polymers on the basis of chlorine substituted glycidyl ethers of polycyclic bisphenols are characterized by incombustibility.</p> 2020-08-31T00:00:00+02:00 Copyright (c) 2020 Givi Papava, Nora Dokhturishvili, Marina Gurgenishvili, Ia Chitrekashvili, Zurab Chubinishvili STUDY OF POLYCONDENSATION PROCESS OF CARBAMIDE WITH FORMALDEHYDE TO RECEIVE BIODEGRADABLE POLYMERS 2020-10-18T20:32:42+02:00 Givi Papava Nazi Gelashvili Eter Gavashelidze Riva Liparteliani Ketevan Archvadze <p>Biodegradation of polymers of spatial structure is complicated at the impact of soil destructive microorganisms and biodegradation requires long time. We have implemented target-oriented synthesis of a polymer to receive linear structure polymers where labile peptide bonds are preserved.<br>To implement target-oriented synthesis of a polymer and to determine optimal conditions for reaction mechanism we studied the process of kinetics and its regularities – reaction temperature, duration, components ratio, concentration, reaction speed constant and activation energy. The Arrhenius factor and succession of introduction of initial components to the reaction medium were computed, catalyst nature and other properties were determined.<br>High effect of prolongation was achieved, when carbamide and formaldehyde molar ratio was 1:1. In this case linear structure polymer is formed where peptide -CH<sub>2</sub> – NH – are preserved.<br>The simplified structure of linear polymer is expressed as followed: – HNCONHCH<sub>2</sub>[ NHCONHCH<sub>2 </sub>]<sub>n</sub> – HNCONHCH<sub>2</sub> – .</p> 2020-09-04T00:00:00+02:00 Copyright (c) 2020 Givi Papava, Nazi Gelashvili, Eter Gavashelidze, Riva Liparteliani, Ketevan Archvadze СОЗДАНИЕ И ИССЛЕДОВАНИЕ ГЕЛИОТЕХНОЛОГИЧЕСКОЙ УСТАНОВКИ С ПОЛИКАРБОНАТНЫМ ПОКРЫТИЕМ 2020-10-18T20:43:02+02:00 Ketevan Archvadze Ilia Chachava Russudan Tsiskarishvili Nanuli Khotenashvili Zurab Tabukashvili <p>The proposed solar dryer (S / D) has a polycarbonate coating, which is actually a combined dryer. By drying an agricultural products in the proposed apparatus, it is possible to get ecologically pure and high quality food. The "greenhouse effect" in S / D ensures the temperature under the glass is 15-25°C, higher than the ambient temperature. In windy weather, the product to be dried cannot be left in the open air due to strong winds, in this device drying in windy weather occurs no less intensively than in hot weather, although the air temperature in S / D is not high. During wind it is recommended to locate the S / D with the inlet towards the wind. The high drying speed occurs due to the increased convective movement. The wind creates a fan effect both at the inlet S / D and at the outlet - at the end of the pipe. In the proposed installation, it is possible to dry various agricultural products, both in direct sunlight and without them.</p> 2020-09-14T00:00:00+02:00 Copyright (c) 2020 Ketevan Archvadze, Ilia Chachava, Russudan Tsiskarishvili, Nanuli Khotenashvili, Zurab Tabukashvili THE INFLUENCE OF SPORTS TO THE FUNCTIONAL POSSIBILITIES OF THE CARDIOVASCULAR SYSTEM OF GIRLS AGED 17-21 OF THE PODILSKY REGION 2020-10-14T14:33:35+02:00 Boiko M. O. Furman Yu. M. Onyshchuk V. E. Havrylova N. V. Miroshnichenko V. M. <p>In this article considers the effectiveness of the impact of sports on the functionality of the cardiovascular system of girls 17-21 years old living within the Podolsk region. The function of the cardiovascular system of girls was evaluated by the ability to recover after termination of work (by the parameters of heart rate). Classes cycling and playing sports (performance of muscle work of which is connected with the mixed mode of power supply) and martial arts (performance of muscular work is associated with anaerobic (lactate) mode of power supply) contribute to improvement the functional possibilities of the cardiovascular system. This is manifested by the acceleration of recovery of heart rate after metered physical loads of 1 watts and 2 watts per 1 kg of body weight. The smallest percentage of person with a slow recovery of heart rate were detected among athletes, volleyball players and representatives of complex coordination sports. These individuals are involved in the performing of physical exercise with anaerobic (alactate) processes of metabolism.</p> 2020-09-04T00:00:00+02:00 Copyright (c) 2020 Boiko M. O., Furman Yu. M., Onyshchuk V. E., Havrylova N. V., Miroshnichenko V. M. MANUAL THERAPY FOR TREATING CHRONIC PELVIC PAIN SYNDROME 2020-10-03T11:05:39+02:00 Sergii Frank Michael Frank George Frank <p>Chronic pelvic pain syndrome is a combination of multiple chronic urogenital pain syndromes. This paper deals with only some of them such as: prostate, bladder and vaginal pain syndromes as well as the possibility of treating non-infectious instances of the said syndromes with manual therapy. The study proves that manual therapy combined with shock wave therapy can successfully aid patients with treatment-resistant manifestations of chronic pelvic pain syndrome, in particular, prostatic, bladder and vaginal pain syndromes, who haven't been able to achieve their desired results through conventional treatment.</p> 2020-08-15T00:00:00+02:00 Copyright (c) 2020 Sergii Frank, Michael Frank, George Frank MORPHOMETRIC CHARACTERISTICS OF GINGIVAL COMPONENTS AT DIFFERENT TERMS OF EXPERIMENTAL OPIOID INFLUENCE 2020-10-03T11:18:12+02:00 Fik V. B. Palʹtov Ye. V. <p>The aim of the study was to investigate changes in morphometric parameters of the gingival epithelial thickness, connective tissue papillae height and lumen diameter of arterioles, capillaries and venules in the dynamics after two, four and six weeks of experimental opioid exposure. Studies were performed on outbred white male rats. In the experiment, animals were injected with increasing opioid analgesic nalbuphine for six weeks, which ranged from 0.212 to 0.252 mg / kg. For histological and morphometric studies, semi-thin sections of the upper and lower jaws of rats were used. It was found that with the introduction of the opioid analgesic nalbuphine in increasing doses, the difference in the components of the periodontium were statistically significant compared with similar values of intact animals, indicating reactive changes in the gingival mucosa during short-term opioid action. After six weeks of opioid exposure, morphometrically revealed a sharp change in the vector of dynamics, which was manifested by statistically significant changes in the values of the components of the gums compared with similar indicators of intact animals, indicating the development of inflammatory- dystrophic changes in periodontal tissues.</p> 2020-08-18T00:00:00+02:00 Copyright (c) 2020 Fik V. B., Palʹtov Ye. V. MANUAL THERAPY FOR TREATING SACROILIAC JOINT PAIN DISORDERS 2020-10-04T12:30:21+02:00 Sergii Frank Michael Frank George Frank <p>Pain in sacroiliac joint structures and their dysfunction constitutes a large portion of lumbosacral spine pathologies. Their symptoms are diverse as they are associated with inflammatory processes in the joints themselves, as well as the instability of the joints and their supporting ligaments. All components of these structures can be a source of pain, so it is quite difficult to diagnose and treat this disease. Treatment of sacroiliac joint pathologies needs to be multifaceted. This study proves that manual therapy combined with shock wave therapy can successfully aid patients with treatment-resistant pain syndromes and dysfunction of sacroiliac joints who haven't been able to achieve their desired results through conventional conservative and surgical treatment.</p> 2020-08-20T00:00:00+02:00 Copyright (c) 2020 Sergii Frank, Michael Frank, George Frank EXPERIMENTAL SUBSTANTIATION OF ASPECTS OF PATHOGENESIS OF PYO-INFLAMMATORY COMPLICATIONS OF ТHORACOABDOMINAL TRAUMAS 2020-10-18T12:33:23+02:00 Дмитрий Минухин Александр Цивенко Alla Korolevska Людмила Тарасенко Дарья Мельник Андрей Шкурат <p>The research presents the pathophysiological substantiation of the MODS and early pyo-inflammatory complications formation during early post-traumatic period of severe blunt thoracic and abdominal trauma in experimental rats. The decrease in intestinal oxygen extraction developed as response to trauma, the permeability of the intestinal barrier is disturbed.<br>It is accompanied by a massive influx of intestinal bacterial endotoxins into the blood, which is manifested by a significant decrease in the concentration of blood plasma Anti-LPS-IgG of rats.<br>This process is an inducer of cascade immunopathological reactions of the body and launching into a number of pathological circles with the subsequent development of MODS and promotes to the development of early pyo-inflammatory complications.</p> 2020-08-28T00:00:00+02:00 Copyright (c) 2020 Дмитрий Минухин, Александр Цивенко, Alla Korolevska, Людмила Тарасенко, Дарья Мельник, Андрей Шкурат RELATIONSHIP BETWEEN THE RESULTS OF IMMUNOHISTOCHEMICAL EXAMINATION (PHH3, KI-67) AND POSITRON EMISSION TOMOGRAPHY DATA (SUVMAX) OF OROPHARYNGEAL SQUAMOUS CELL CARCINOMA 2020-10-18T12:57:55+02:00 Lysak Andrii Diadyk Olena <p>The authors established the relationship between the indicators of immunohistochemical examination — proliferation markers (Ki67) and mitotic count (pHH3) with the indicators of positron emission tomography — SUVmax. The identified patterns of cancer cells differentiation and their metabolic activity are promising for the diagnosing and screening of tumours of varying degrees of progression and origin, which will allow forecasting the course of the disease at all stages of diagnostics. The study intends to assess the level of oropharyngeal squamous cell histopathological differentiation by immunohistochemical diagnostic methods, and their metabolic activity using positron emission tomography.<br>1. Study of the activity of metabolic processes of transformed oropharyngeal cancer cells using positron emission tomography;<br>2. Determination of tumour proliferative potential by the number of positive stains to Ki-67 (%) and pHH3 by immunohistochemical diagnostic methods;<br>3. Identification of the relationship between morphological changes of oropharyngeal cancer cells and their metabolic activity.<br>Materials and methods. We studied 130 samples of squamous cell carcinoma of the oropharyngeal area. We determined the level of metabolic activity — SUVmax — by positron emission tomography (PET) at the preoperative patient treatment stage. In the postoperative period, the proliferation index (Ki67) and the mitotic count (pHH3) were determined by histological and immunohistochemical methods. Upon assessment of the level of differentiation of tumour cells, patients were divided into three groups: Group I - patients having tumour cells in the G1 phase of mitosis (28 patients); Group II — tumour cells in the G2 phase of mitosis (48 patients); Group III — tumour cells in the G3 phase of mitosis (54 patients). We evaluated PET results according to the Maximum Standard Unit Value (SUVmax).<br>We determined the relationship between morphological changes and metabolic activity of tumour cells by 2- fluoro-[18F]-2-deoxy-D-glucose accumulation and immunohistochemical examination.<br>Results. We established a statistically significant difference between the groups (p&lt;0.001 according to the Kruskal- Wallis test for all indicators). Thus, with decreasing Me level, the differentiation of SUVmax of tumours significantly (p&lt;0.05) increases, which indicates an increase in the degree of malignancy of tumours. We evaluated the results of immunohistochemical examination by Ki67 and pH3 markers in the study groups. Comparing Ki67 and pHH3, a statistically significant difference was found between the groups (p&lt;0.001 according to the Kruskal- Wallis test for all indicators). Thus, with a decrease in the Me level, the differentiation of Ki67 increases significantly (p&lt;0.05), and an increase in pH3 indicates an increase in the degree of malignancy of tumours. Conclusions. We statistically proved the relationship between Ki67, pH3 and SUVmax in oropharyngeal squamous cell carcinoma. We established the possibility of preoperative forcasting of the level of tumour differentiation and the use of pHH3 immunohistochemical marker as a reliable criterion for assessing the level of tumour differentiation, including hardly diagnosable squamous cell carcinoma.</p> 2020-08-30T00:00:00+02:00 Copyright (c) 2020 The authors MANUAL THERAPY IN THE TREATMENT OF TEMPOROMANDIBULAR JOINT AND MENISCUS DISLOCATION 2020-10-14T12:40:06+02:00 Сергій Франк Михайло Франк Георгій Франк <p>The treatment of temporomandibular joint and meniscus dislocation belongs to the field of dentistry and maxillofacial surgery and is considered to be a lengthy and complex process. In this paper, the authors attempt to link the occurrence of such dislocations with pathological conditions of the upper segments of the cervical spine and prove that manual correction of the affected segments of the spine significantly accelerates and facilitates the treatment of temporomandibular joint and meniscus dislocations.</p> 2020-09-04T00:00:00+02:00 Copyright (c) 2020 Сергій Франк, Михайло Франк, Георгій Франк DYNAMICS OF PHOSPHATE LEVEL AND ADAPTATION POTENTIAL IN THE IMPLEMENTATION OF THE ERAS-PROTOCOL IN OVERWEIGHT PATIENTS WITH A SURGICAL PROFILE 2020-10-14T12:52:24+02:00 Dyachenko Hlib Dmytrovych Volkova Yuliya <p>The results of the treatment of overweight patients under the ERAS program are presented. When comparing different variants of the intensive care protocol, it is best to add colecalciferol and D-fructose-1,6-diphosphate sodium salt hydrate.<br>An increase in the amount of secretory active adipose tissue in the body is accompanied by a decrease in the bioavailability of vitamin D, a decrease in the level of 25 (OH) D in the blood increases the level of parathyroid hormone. The introduction of a planned surgical profile in overweight patients at the screening stage 10 days before surgery to determine the level of 25 (OH) D in the blood is a key point in deciding the possibility of a perioperative period under the ERAS program. Additional use to its classic protocol of colecalciferol (positive effect on long-term effects and is significant in the prediction process) and sodium D-fructose-1,6-diphosphate hydrate solution (directly affects the effect of rapid recovery after elective surgery) improves the quality of motor activity of patients after operations, increases their adaptive capacity by restoring lost muscle function. The optimized classical algorithm of the ERAS program significantly (p &lt;0.05) improved the quality of life in the long run (30 days after surgery), such as physical functioning, general health, viability scale, mental health (SF-36 scale) and reduced body mass index.</p> 2020-09-08T00:00:00+02:00 Copyright (c) 2020 Dyachenko Hlib Dmytrovych, Volkova Yuliya EFFECTS OF MANUAL CORRECTION OF PELVIC TILT ON THE COURSE OF ONYCHOCRYPTOSIS 2020-10-14T13:03:19+02:00 Сергій Франк Михайло Франк Георгій Франк <p>The study conducted proves that pelvic tilt is one of the root causes of onychocryptosis. Recovering the correct position of pelvic bones via manual methods restores the symmetrical position of the nail edge in the lateral nail fold of a toe, thus preventing any damage to the soft tissues of the lateral nail fold which is what causes onychocryptosis in the first place. By correcting pelvic bone imbalance via manual methods, we can therefore eliminate onychocryptosis without even touching the affected toe.</p> 2020-09-12T00:00:00+02:00 Copyright (c) 2020 Сергій Франк, Михайло Франк, Георгій Франк INFLUENCE OF SUBARACHNOID ANESTHESIA IN THE PRONE POSITION ON THE ENERGY OF CIRCULATION 2020-10-14T13:14:54+02:00 Mykhnevych Kostiantyn Georgijovych Volkova Yuliya Viktorivna Kudinova Olha Vasylivna Dolgopolova Anastasia Valeriivna Lutska Svitlana <p>The energy supply of the body has an energy price, which is paid, in particular, by the myocardium. This price depends on the circulatory conditions, which can also be affected by iatrogenic factors, such as subarachnoid anesthesia (SA) in the prone position. Decreasing of a vascular tone under the influence of SA requires the myocardium to increase energy consumption to maintain an adequate cardiac index (CI). With a resistive type of circulation, autoregulation of blood circulation may become untenable, that requires artificial maintenance of vascular tone with the α1-adrenomimetics, that also contribute to an increase in energy expenditure by the myocardium. All this makes the assessment of blood flow energy relevant.<br>The aim of the study was to study the effect of SA in the prone position on the energy of circulation.<br>65 patients underwent transpedicular stabilization of 1-2 segments under SA in the prone position have been examined. On the eve of the operation, the prognostic index of hemodynamic instability (PIHI) has been determined by the N. Lysohub’s method. At three stages (the position on the back after performing SA, 5 and 20 minutes after turning on the prone position), kinetic (systolic index, ejection fraction, heart rate and SI), dynamic (effective, or average, AP — APe, central venous pressure, the difference between them — systemic perfusion pressure and specific peripheral vascular resistance) and hemic (blood oxygen content) indicators have been determined. Based on these indicators and the energy potential of oxygen (the energy obtained by glucose oxidation by 1 mol of oxygen), the following energy parameters have been calculated: flow power index (FPI), tissue power consumption index (TPCI), oxygen reserve (OR) and circulatory reserve index (CRI). APe was maintained at least 60 mm Hg during anesthesia by infusion and, if necessary, by administration of the α1- adrenomimetic phenylephrine. Patients have been retrospectively divided into 2 groups: patients of the VF1 group (n = 25) needed phenylephrine administration, and patients of the VF2 group (n = 40) did not need it.<br>The following results have been obtained. The minimum PIHI in the VF1 group was 0.1, which made it possible to expect a high probability of hemodynamic instability, while in the VF2 group it was no higher than 0.05. The integral kinetic parameter CI in the groups did not differ significantly, but the energy consumption and their efficiency between the groups significantly differed. FPI in the VF1 group was significantly lower than in the VF2 group, although TPCI did not differ significantly between the groups. TPCI compliance with tissue needs was determined by OR, which was significantly lower in the VF1 group. The final parameter CRI was significantly lower in the VF1 group, although CI did not differ significantly from the VF2 group level. This indicates energy insufficiency of circulation in patients with a resistive type of circulation against the background of SA in the prone position, so with this type, the presence of which is confirmed by a high PIHI, preference should be given to another type of anesthesia.</p> 2020-09-14T00:00:00+02:00 Copyright (c) 2020 The authors COMPARISON OF PLASMA COAGULABILITY AFTER SHORT-TERM TREATMENT WITH ROSUVASTATIN VERSUS ATORVASTATIN IN UNSTABLE ANGINA PATIENTS 2020-10-14T14:23:14+02:00 Yuliya Tyravska Viktor Lizogub Nataliia Raksha Oleksii Savchuk <p>Statins are the integral medications for the management of patients with acute coronary syndrome including unstable angina (UA) with multiple pleiotropic effects. However, the influence of statins on the coagulation system is controversial. Our study aimed to explore the effects of atorvastatin and rosuvastatin in high doses on some coagulation parameters (prothrombin pool (PP) and soluble fibrin-monomer complexes (SFMC) concentration) after a 7-days follow-up period in patients with UA. We recruited 50 patients aged 55 to 70 years with progressive UA. Standard therapy according to ESC guidelines 2020 was recommended for all patients. Before treatment onset, they were divided into 2 groups: group A – 26 patients were prescribed atorvastatin, group R – 24 patients with rosuvastatin treatment. The blood samples to analyze the concentration of PP and SFMC were collected twice – before the treatment onset and 7 days after. We revealed significant decrease in PP concentration (p=0,02) and increase in SFMC concentration (p=0,01) in group A patients while there were no significant changes of investigated parameters (p=0,94, p=0,57 respectively) in group R. Additionally, we have noted significant negative correlation between baseline PP concentration and direction of PP changes (r=-0,803, p&lt;0,001) as well as PP changes direction and SFMC concentration after treatment (r=-0,655, p&lt;0,001). Thus, we may consider that atorvastatin and rosuvastatin are characterized by different influences on coagulation in patients with progressive UA with standard basic treatment. The rebound coagulation system activation after anticoagulant discontinuation is more pronounced in UA patients against a background of atorvastatin treatment in comparison with rosuvastatin.</p> 2020-09-14T00:00:00+02:00 Copyright (c) 2020 Yuliya Tyravska, Viktor Lizogub, Nataliia Raksha, Oleksii Savchuk INNOVATIONS IN NANOMEDICINE AND NANOPHARMACY 2020-10-03T17:00:35+02:00 Brubaker I. O. Bilan O. A. Marchenko-Tolsta K. S. <p>The review examines current trends in the development of biomedical nanotechnology, its application in various fields of medicine and prospects for further development. Among the main directions — monitoring and control of delivery, distribution and use of drugs; nanobiosensors; diagnostics of pathological states; theranostics; use of nanostructured materials in regenerative medicine; nanotoxicology; nanophytopharmacy; green synthesis; development of new nanobiotech devices and nanorobototics.</p> 2020-08-20T00:00:00+02:00 Copyright (c) 2020 Brubaker I. O., Bilan O. A., Marchenko-Tolsta K. S. ANALYSIS OF THE MODERN STATE OF SPORT NUTRITION DEVELOPMENT IN THE WORLD AND UKRAINE 2020-10-15T08:58:51+02:00 Alla Nemchenko Viktoriia Mishchenko Olena Vynnyk <div class="page" title="Page 2"> <div class="layoutArea"> <div class="column"> <p>Today, such a segment of the market as sports nutrition (SN) is dynamically developing due to the active growth of interest in sports among the population (the average annual growth of the global SN market in the next five years will be from 8.1% to 11.0%), which is why the analysis the current state of SN development in the world and Ukraine is a pressing issue. There are 62.2 million citizens in Europe today, including 1.2 million Ukrainians. Currently, the global SN market is actively developing and valued at more than $ 10 billion, and domestic at $ 90 million. US dollars. Currently, a pharmacy network of online stores "" Your Health and Beauty "is being developed in Ukraine, which together with preventive products offers SN. In the assortment of the network the dependency is established: foreign brands predominate - Weider (USA / Germany, 14,8%), Kevin Levrone (Poland, 13,8%), Optimum Nutrition (USA, 7,6%). Unfortunately, only 10.0% of the analysed products are manufactured in Ukraine (Levobol, Fitness Factor). The majority of SN is dry powder mixtures (65%); the predominant weight of SN is 0.500 kg (18%); dominated by taste: vanilla (17%), chocolate and strawberries (12% each); by designation proteins (62%) and fat burners (19%) are preferred. Currently, many scientists are paying close attention to the problems of analysing the feasibility and physiological importance of using SN products in the diets of both athletes and consumers seeking to lead an active, energetic and healthy lifestyle, so that monitoring of SN status in the world and in different countries is a pressing issue today.</p> </div> </div> </div> 2020-08-24T00:00:00+02:00 Copyright (c) 2020 The authors TECHNICAL TRAINING OF GYMNASTS-ARTISTS AT THE STAGE OF SPORTS IMPROVEMENT 2020-10-18T20:51:14+02:00 Akhmedova Jamilya Adizovna <p>The following article discusses the problem of organizing and monitoring the special-physical and technical training of young gymnasts at the stage of sports improvement. It is shown that the main advantage achieved during the training session with objects is the regulation of the number of repetitions at high work intensity.</p> 2020-09-01T00:00:00+02:00 Copyright (c) 2020 Akhmedova Jamilya Adizovna PHYSIOTHERAPY AS A MEANS OF IMPROVING THE PHYSICAL AND FUNCTIONAL PERFORMANCE OF YOUNG TRIATHLETES 2020-10-18T21:05:36+02:00 Niyazova Regina Rustamovna <p>The article deals with the problem of finding methods of restorative means that increase the body's performance and search for integral characteristics of the effectiveness of adaptation of the athlete's body to high volume and intensity of training and competitive loads.</p> 2020-09-18T00:00:00+02:00 Copyright (c) 2020 Niyazova Regina Rustamovna