ДИНАМІКА МОРФОЛОГІЧНИХ ЗМІН СТРУКТУРНИХ КОМПОНЕНТІВ ХРЯЩОВОГО ПОКРИТТЯ КОЛІННОГО СУГЛОБА НА УЛЬТРАСТРУКТУРНОМУ РІВНІ НАПРИКІНЦІ ПЕРШОГО, ДРУГОГО ТА ТРЕТЬОГО ТИЖНІВ ОПІОЇДНОГО ВПЛИВУ

  • Войценко К. І. Львівський національний медичний університет імені Данила Галицького, кафедра нормальної анатомії, м. Львів, Україна
  • Пальтов Є. В. Львівський національний медичний університет імені Данила Галицького, кафедра нормальної анатомії, м. Львів, Україна
  • Кривко Ю. Я. Львівський національний медичний університет імені Данила Галицького, кафедра нормальної анатомії, м. Львів, Україна
  • Голейко М. В. Львівський національний медичний університет імені Данила Галицького, кафедра нормальної анатомії, м. Львів, Україна
Keywords: experimental opioid exposure, rat, knee joint, articular cartilage

Abstract

The work presented below, aimed at studying the onset, development and manifestations of pathomorphic chondropathy in acute and subchronic experimental exposure of opioid analgesics. The objective was achieved by using microscopic visualization technique of cellular components of the articular cartilage. To obtain the microstructural materials we applied generally accepted, conventional methods.
The results of the study in the future will allow to form a pathomorphological basis, which can be used for a comparative characterization of the structural components of the articular cartilage of the knee joint in the early and late stages (acute and subchronic) of experimental opioid exposure.

References

Adrashkin, A. P, Salomatin, I. V, & Murashov, B. F. (2003). The role of the cardiovascular system in thanatogenesis in opiate addicts of the second stage. From research to treatment standards: Newsletter on the Russian National Congress of Cardiology. Moscow: Russian Society of Cardiology, 18.

Raietska, L. V. (2008). Trends in the spread of drug addiction in Ukraine. Fighting organized crime and corruption, 18, 67-76.

Treshchinskiy, I. S., Kharchenko, L. A., & Usenko, V. A. (1998). Some issues of drug addiction and substance abuse in Ukraine. Pharmacist, 4, 15-17.

Logash M., & Pokotylo P. (2013). Some aspects of the history of opiates in the context of nowadays drug addiction problems. Bulletin of Biology and Medicine, 4-1 (42), 129-131.

Yakimiv N.Y. (2014). Ultrastructural characteristics structures prismatic-corneal angle eyeball rats after opioid exposure. World of Medicine and Biology, 2 (44), 185-188.

Yakimiv NY. (2014). Ultrastructural characteristics of irido-corneal angle of eye of rats on 7th,14th, 21st and 28th days of opioid influence. Ukrainian morphological almanac, 2, 28-31.

Paltov Ye.V. (2004). Morphological features of the anatomy of the arterial bed of the neck and maxillofacial area of the rat are normal. Scientific herald of the SZ Gzhytsky Lviv National Academy of Veterinary Medicine, 6-1(1), 113-119.

Paltov Ye.V. (2004). Roengenoanatomy of the arteries of the rat head and neck. Clinical anatomy and operative surgery, 3 (2), 26-29.

Paltov Ye.V., Kryvko Yu.Ya., Tomashova S.A., Vil’hova I.V., & Matkivskyi R.M. (2006). The state of microstructural organization of soft tissues of periodontal disease in white rats in norm and their change at different stages of the course of experimental streptozotocin diabetes mellitus. Bulletin of the Sumy State University, 2 (86), 36-43.

Paltov Ye.V., & Kryvko Yu.Ya. (2006). The ultrastructural organization of soft tissues of periodontal disease in white rats is normal and the dynamics of their changes during the course of streptotsotocin- induced experimental diabetes mellitus. World of Medicine and Biology, 3, 35-44.

Paltov Ye.V., Chelpanova I.V., Fik V.B., Vil’hova I.V., Kyryk Kh.A., & Kryvko Yu.Ya. (2017). Pathomorphological changes in layers of retina for six weeks of opioid exposure experiment. World of Medicine and Biology, 2 (60), 146-150.

Paltov Ye.V., & Kryvko Yu.Ya. (2017). Pathological changes in the layers of the retina after eight weeks of opioid influence at the experiment. Bulletin of problems biology and medicine, 4-2 (140), 118-122.

Paltov Ye.V., Fik V.B., & Kryvko Yu.Ya. (2018). Pathomorphological changes in the retina layer at the end of the fourth week of opioid effect, Natural Science Readings abstracts booc. Sosnowiec-Bratislava, 30-32.

Fik V .B., Paltov E.V ., Loh ash M.V ., & Kr yvk o Y u.Y a. (2017). Pecularities of mor ph ological manifestation of the periodontal tissue in experimental animals against the ground of a short-term effect of opioid analgesic. Deutsch. Wissenscaftsch, 2, 54-58.

Fik V.B., Kryvko Yu.Ya., & Paltov E.V. (2018). Microstructural changes of periodontal tissue under the action of opioid analgesics in the early stages. Bukovinian Medical Herald, 22-1 (85), 141-148.

Fik V.B., Paltov E.V., & Kryvko Yu.Ya. (2018). Morphofunctional peculiarities of the periodontal tissue under conditions of simulated eight-week opioid effect. Deutscher Wissenschaftscherold German Science Herald, 1, 14-17. DOI:10.19221/201814.

Onisco, RM, Paltov, YV, Fik, VB, Fitkalo, OS. (2013). Ukraine. Patent No. 76564. Kyiv: Ukrainian Institute of Intellectual Property (Ukrpatent).

Glauert A.M. (1975). Fixation, Dehydration and Embedding of Biological Specimens. In: Practical methods in electron microscpi. North-Hollond: American Elsevier.

Stempak J.G., & Ward R.T. (1964). An improved staining method for electron microscopy. J Cell Biol, 22 (3), 697-701.

Reynolds E.S. (1963). The use of lead citrate at high pH as an electronopague stain in electron microscopy. J Cell Biol, 17, 208-212.

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Published
2019-01-31
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How to Cite
Войценко К. І., Пальтов Є. В., Кривко Ю. Я., & Голейко М. В. (2019). ДИНАМІКА МОРФОЛОГІЧНИХ ЗМІН СТРУКТУРНИХ КОМПОНЕНТІВ ХРЯЩОВОГО ПОКРИТТЯ КОЛІННОГО СУГЛОБА НА УЛЬТРАСТРУКТУРНОМУ РІВНІ НАПРИКІНЦІ ПЕРШОГО, ДРУГОГО ТА ТРЕТЬОГО ТИЖНІВ ОПІОЇДНОГО ВПЛИВУ. Science Review, (1(18), 3-10. https://doi.org/10.31435/rsglobal_sr/31012019/6334
Section
Medicine