MORPHOLOGY OF THE HEART IN THE DELAYED PERIOD OF EXPOSURE TO LOW DOSES OF LEAD
Abstract
The aim of this study was to investigate the delayed effects of low doses of lead exposure on the hart using an original experimental model for studying the delayed effects. Analysis of the obtained morphological picture revealed structural abnormalities affecting both the muscular and stromal-vascular components. The degree of damage is in direct correlation with the received dose of lead. The above indicates that lead loading, even in low doses, is accompanied by structural abnormalities in the heart even after a long time. Most likely, this is due to the ability of lead to accumulate in the body and remain there for a long time. Vascular disorders play a certain, if not the main, role in the damage to muscle cells. However, the presence of a complex mechanism, which also implies primary damage to cardiomyocytes under the influence of lead, cannot be ruled out. Due to the properties of lead and its impact on the body, and also due to the fact that it is impossible to stop the spread of lead in nature, it is important, along with the study of the mechanisms and results of lead exposure, to find prophylactic means that displace lead ions from the body and regulate metabolism, which is affected by their activity.
References
Atchison W.D. (2003). “Effects of toxic environmental contaminants on voltage-gated calcium channel function: from past to present” J Bioenerg Biomembr. 35:507–532. [in English].
Bhatnagar A. (2006). “Environmental cardiology: studying mechanistic links between pollution and heart disease” Circ Res. 99:692–705. [in English].
Bressler J., K-a K., Chakraborti T., Goldstein G. (1999). “Molecular mechanisms of lead neurotoxicity” Neurochem Res. 24:595–600. [in English].
Carmignani M., Boscolo P., Poma A., Volpe A.R. (1999). “Kininergic system and arterial hypertension following chronic exposure to inorganic lead” Immunopharmacology. 44(1-2):105–110. [in English].
Ding Y., Vaziri N.D., Gonick H.C. (1998). “Lead-induced hypertension. II. Response to sequential infusions of l-arginine, superoxide dismutase, and nitroprusside” Environ Res. 76(2). 107-113. [in English].
Dursun N., Arifoglu C., Süer C., Keskinol L. (2005). “Blood pressure relationship to nitric oxide, lipid peroxidation, renal function, and renal blood flow in rats exposed to low lead levels” Biol Trace Elem Res. 104(2):141–149. [in English].
Engwa G.A. et al. (2019). “Mechanism and health effects of heavy metal toxicity in humans Poisoning in the Modern World-New Tricks for an Old Dog?” Intech Open (2019), 10.5772/intechopen.82511. [in English].
Ekong E. B., Jaar B. G., Weaver V. M. (2006). “Lead-related nephrotocixity: a review of the epidemiologic evidence” Kidney Int. 70(12):2074–2084. [in English].
Farmand F., Ehdaie A., Roberts C.K., Sindhu R.K. (2005). “Lead-induced dysregulation of superoxide dismutases, catalase, glutathione peroxidase, and guanylate cyclase” Environ Res. 98(1):33–39. [in English].
Gidlow D.A. (2015). “Lead toxicity” Occup Med (Oxford, England) 65:348-356. [in English].
Heo Y., Parsons P.J., Lawrence D.A. (1996). “Lead differentially modifies cytokine production in vitro and in vivo” Toxicol Appl Pharmacol. 138:149–157. [in English].
Kirberger M., Yang J.J. (2008). “Structural differences between Pb 2+ and Ca 2+ binding sites in proteins: implications with respect to toxicity” J Inorg Biochem. V.102, Issue 10. 1901–1909. [in English].
Lancéreaux E. (1881). “Nephrite et arthrite saturnine; coincidences de ces affections; parallèle ave la néphrite et l’arthrite goutteuses” Transact Int Med Congr. 2:193–202. [in French].
Lopez A.D. et al. (2006). “Global and regional burden of disease and risk factors, 2001: systematic analysis of population health data” Lancet. 367:1747–1757. [in English].
Lorimer G. (1886). “Saturnine gout, and its distinguishing marks” BMJ. 2:163. [in English].
Lundström N.G. et al. (1997). “Cumulative lead exposure in relation to mortality and lung cancer morbidity in a cohort of primary smelter workers” Scandinavian Journal of Work, Environment & Helt. 23(1).24-30. [in English].
Manning K.L., Wünschmann A., Redig P. (2018). Lead intoxication in free-ranging bald eagles (Haliaeetus leucocephalus). Veterinary Pathology. V. 56. Issue 2. [in English].
Mermanishvili T., Pataraia G., Chachia G., Chanturidze N. (2022). “Adverse effects of excess lead doses on the heart muscle” II of the world Scientific Conference "Health and Sport", Tbilisi, May 17-18. [in Georgian].
Minaii B., Towfighi Z., Abdollahi M. (2008). “Toxicity of lead acetate on rabbit arteries: a histological evaluation” Toxicology Letters 180(2), 180(2). [in English].
Muntner P., Menke A., DeSalvo K.B., Rabito F.A., Batuman V. (2005). “Continued decline in blood lead levels among adults in the United States: The National Health and Nutrition Examination Surveys” Arch Intern Med. 165(18) 2155-2161. [in English].
Navas-Acien A. et al. (2007). “Lead Exposure and Cardiovascular Disease - A Systematic Review” Environ Health Perspect. Mar; 115(3): 472-482. [in English].
Nicolas de Francisco O., Feeney D., Armien A., Wunschmann A., Redig P.T. (2016). “Correlation of brain magnetic resonance imaging of spontaneously lead poisoned bald eagles (Haliaeetus leucocephalus) with histologic lesions: a pilot study” Vet. Sci. 105: 236-242. [in English].
Pataraia G. et al. (2018). “Delayed effects of lead exposure: An experimental model and epidemiological research” Nova Science Publishers Inc. USA. 271-280. [in English].
Pataraia G., Mermanishvili T., Chanturidze N. (2021). Lead Exposure as a Premise for Limiting the Ability to Maximize the Realization of Physical Activity. World Science 10(71) RS Global Sp. z O.O., Pl.2021. https://doi.org/10.31435/rsglobal_ws/30112021/7699. [in Russian].
Revis NW, Zinsmeister AR, Bull R. (1981). “Atherosclerosis and hypertension induction by lead and cadmium ions: an effect prevented by calcium ion” Proc Natl Acad Sci USA. 78(10). 6494–6498. [in English].
Rodriguez-Iturbe B., Sindhu R.K., Quiroz Y., Vaziri N.D. (2005). “Chronic exposure to low doses of lead results in renal infiltration of immune cells, NF-kB activation, and overexpression of tubulointerstitial angiotensin II” Antioxid Redox Signal. Vol. 7. No 9-10. 1269–1274. [in English].
Steenland K., Selevan Sh., Landrigan Ph. (1992). “The mortality of lead smelter workers: an update” American Journal of Public Health. Vol. 82, No. 12. P. 3. [in English].
Stohs S.J., Bagchi D. (1995). “Oxidative mechanisms in the toxicity of metal ions” Free Radic Biol Med. 18(2). 321–336. [in English].
US EPA (2006). “Air Quality Criteria For Lead (Final Report)” U.S. Environmental Protection Agency. [in English].
Vaziri N.D., Ding Y., Ni Z. (2001). “Compensatory up-regulation of nitric-oxide synthase isoforms in lead-induced hypertension; reversal by a superoxide dismutase-mimetic drug” J Pharmacol Exp Ther. 298(2):679-685. [in English].
Vorvolakos T., Arseniou S., Samakouri M. (2016). “There is no safe threshold for lead exposure: A literature review” Psychiatriki. 27:204–214. [in English].
Wang Ch. et al. (2004). “Platycodin D and D3 isolated from the root of Platycodon grandiflorum modulate the production of nitric oxide and secretion of TNF-α in activated RAW 264.7 cells” International Immunopharmacology. V. 4. Issue 8. [in English].
Weinhold B. (2004). ”Environmental cardiology: getting to the heart of the matter” Environ Health Perspect. 112(15):880–A887. [in English].
WHO (2017). “Guidelines for drinking-water quality” WHO Chronicle, 38, 104-108. [in English].
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