MORPHOLOGY OF THE HEART IN THE DELAYED PERIOD OF EXPOSURE TO LOW DOSES OF LEAD
Abstract
The aim of this study was to investigate the delayed effects of low doses of lead exposure on the hart using an original experimental model for studying the delayed effects. Analysis of the obtained morphological picture revealed structural abnormalities affecting both the muscular and stromal-vascular components. The degree of damage is in direct correlation with the received dose of lead. The above indicates that lead loading, even in low doses, is accompanied by structural abnormalities in the heart even after a long time. Most likely, this is due to the ability of lead to accumulate in the body and remain there for a long time. Vascular disorders play a certain, if not the main, role in the damage to muscle cells. However, the presence of a complex mechanism, which also implies primary damage to cardiomyocytes under the influence of lead, cannot be ruled out. Due to the properties of lead and its impact on the body, and also due to the fact that it is impossible to stop the spread of lead in nature, it is important, along with the study of the mechanisms and results of lead exposure, to find prophylactic means that displace lead ions from the body and regulate metabolism, which is affected by their activity.
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