PROSPECTS FOR THE USE OF ZEOLITE CONTAINING GEOMIN FORTE IN THE TREATMENT OF COVID-19 AND POST COVID-19 CONDITION

Marina Giorgobiani; Nana Gorgaslidze; Aliosha Bakuridze; Lasha Bakuridze; Nodar Sulashvili

doi:10.31435/rsglobal_ws/28022022/7781

Marina Giorgobiani MD, PhD, Doctor of Medical Sciences, Professor of Tbilisi State Medical University, Faculty of Public Health, Department of Hygiene and Medical Ecology, Tbilisi, Georgia
Nana Gorgaslidze MD, PhD, Doctor of Pharmaceutical Sciences, Professor of Tbilisi State Medical University, Faculty of Pharmacy, Head of The Department of Social and Clinical Pharmacy, Tbilisi, Georgia
Aliosha Bakuridze MD, PhD, Doctor of Pharmaceutical Sciences, Professor of Tbilisi State Medical University, Faculty of Pharmacy, Head of The Department of Pharmaceutical Technology, Tbilisi, Georgia
Lasha Bakuridze MD, PhD, Doctor of Pharmaceutical Sciences, Associate Professor of Tbilisi State Medical University, Faculty of Pharmacy, Department of Pharmaceutical Technology, Tbilisi, Georgia
Nodar Sulashvili MD, PhD, Doctor of Theoretical Medicine in Pharmaceutical and Pharmacological Sciences, Associate Professor of Alte University, International School of Medicine, Division of Pharmacology, Invited Professor of Tbilisi State Medical University, Tbilisi, Georgia

DOI: https://doi.org/10.31435/rsglobal_ws/28022022/7781

Keywords: Prospects, use, zeolite containing Geomin Forte, treatment, covid-19, post covid, condition.

Abstract

The aim of the research was to study and analyze peculiarities and prospects for the use of zeolite containing Geomin Forte in the treatment of covid-19 and post covid-19 condition. Antioxidants are substances that the human body constantly needs in order to maintain it in a normal state, which means maintaining the necessary balance between free oxidative radicals and antioxidant forces, the role of which is played by antioxidants.
Vitamin E increases the body's nonspecific resistance, and by activating the synthesis of cytokines, tocopherol stimulates its own anti-inflammatory activity. The effect of vitamin E is to stimulate the reproduction of immune cells, systems that need to quickly multiply when they meet the source of a possible disease. In the body, this process is called mitogenesis.
The pharmacodynamic effects of tocopherol are synergistic when combined with vitamins C and A. Retinol provides formation of immune (protective) cells, lining respiratory tract and gastrointestinal tract, serving as a natural barrier to infection. Medicine will enhance possibilities of adaptation of the organism to the changed environment, because, in many cases, it is very difficult to protect the population from the impact of the negative factor (including ionizing radiation, natural disasters, etc.) According the study results “Geomin Forte” can be used during intoxications (used as the best sorbent for food, infectious, occupational intoxications, chronic metals and chronic exposure to radiation). As well as when the functional state of the immune system is impaired and fatigue and as an adjunct for allergic diseases. The mineral zeolite (clinoptilolite), the 500 mg activated clinoptilolite "Geomin Forte" developed by us is characterized by antioxidant action. Unlike the conventional antioxidants, it stimulates the body's endogenous antioxidant system and is a direct-acting oxidoreductive agent. Its activated natural mineral zeolite (clinoptilolite) acts directly on the cell membrane as a surface-active donor of electrons.
With its oxidizing effect, "Geomin Forte" is 200 times more than vitamins C and E. Used in combination with antioxidant therapy in the context of standard treatment for the following diseases: Diabetes mellitus, accelerated aging process; alzheimer's disease; parkinson's disease; endocrine pathologies; atherosclerosis and ischemic heart disease, hypertensive disease, stroke, rheumatism.

References

Mousavizadeh L, Ghasemi S. Genotype and phenotype of COVID-19: Their roles in pathogenesis. Journal of Microbiology, Immunology and Infection. 2020 Mar 31.

De Wilde, Adriaan H et al. “Host Factors in Coronavirus Replication.” Current topics in microbiology and immunology vol. 419 (2018): 1-42.

Pan Zhai 1, Yanbing Ding 1, Xia Wu 2, Junke Long 3, YanjunZhong 4, Yiming Li 5The Epidemiology, Diagnosis and Treatment of COVID-19Int J Antimicrob Agents. 2020 May;55(5):105955.

Liu H, Wang LL, Zhao SJ, Kwak-Kim J, Mor G, Liao AH. Why are pregnant women susceptible to viral infection: an immunological viewpoint, Journal of reproductive immunology, 2020 Mar 19:103122.

World Health Organization. Novel Coronavirus (2019-nCoV) technical guidance: Patient management.

https://www.who.int/emergencies/diseases/novel-coronavirus-2019/technical-guidance/patient-management (Accessed on February 02, 2020).

Kickbusch I, Leung G. Response to the emerging novel coronavirus outbreak. BMJ 2020; Pp 36-40.

World Health Organization. COVID 19 Landscape of experimental treatments. Retrieved from https://www.who.int/publications-detail/covid-19-landscape-of-experimental-treatments (Accessed on April 29, 2020).

https://www.sciencemag.org/news/2020/04/new-york-clinical-trial-quietly-tests-heartburn-remedy-againstcoronavirus (Accessed on April 27, 2020).

Amarowicz R., Pegg R.B., Rahimi-Moghaddam P., Barl B., Weil J.A. Free-radical scavenging capacity and antioxidant activity of selected plant species from the Canadian prairies. Food Chem. 2014; 84:551–562.

Besco E., Braccioli E., Vertuani S., Ziosi P., Brazzo F., Bruni R., Sacchetti G., Manfredini S. The use of photochemiluminescence for the measurement of the integral antioxidant capacity of baobab products. Food Chem. 2007; 102:1352–1356.

Bou Ghanem E.N., Clark S., Du X., Wu D., Camilli A., Leong J.M., Meydani S.N. The α-tocopherol form of vitamin E reverses age-associated susceptibility to streptococcus pneumoniae lung infection by modulating pulmonary neutrophil recruitment. J. Immunol. 2015; 194:1090–1099.

Padayatty, S. J., Katz, A., Wang, Y., Eck, P., Kwon, O., Lee, J.–H., Chen, S., Corpe, C., Dutta, A., Dutta, S. K, Levine, M. Vitamin C as an Antioxidant: Evaluation of Its Role in Disease Prevention. //J. Am. Coll. Nutrition – 2013.– Vol. 22.– P. 18–35.

Giorgobiani M., Zurashvili B., Bakuridze Al., Putkaradze J. _ Zeolites for human health //Georgian Moambe, 2006, January-March, p. 213-215.

Putkaradze J., Pantsulaia I., Giorgobiani M., et.al. – New Nutritional Supplement: Georgian Zeolites enriched with Extracts of the Edible Plant//”1International Symposium and Advanced Course” Active Pharmaceutical ingredients from research to industrial and regulatory issues”, APIB – 2009, June, 3-6, p.41.

Giorgobiani M., Bakuridze Al., Zurashvili B., Rutkaradze J., Bakuridze L. - Modern radioecological problems and prospects for the use of antioxidants of mineral origin for strengthening the health of the population. Ministry of Health of Ukraine Chroni // Khark ი in, 2013, 30.

Retrieved from www.megamin

Andrea Mastinou, Amit Kumar, Giuseppina Maccarinelli, Sara Anna Bonini, Marica Premoli, Francesca Aria, Alessandra Gianoncelli, Maurizio Memo. Zeolite clinoptilolite: healing properties of an ancient mineral

Retrieved from https://investrd.ru/ka/interesting/kak-lechit-radiaciyu-vyvodim-radiaciyu-posle-rentgenachem-opasno.html

Retrieved from https://pubmed.ncbi.nlm.nih.gov/15310086/

M. Giorgobiani, B. Zurashvili, A. Bakuridze et al. Prospects for the use of Georgian zeolites in medical, pharmaceutical and environmental technologies, Allergology and Immunology, vol. 9, No. 5, October, 2008, p. 560-562

M. Giorgobiani, A. Bakuridze, B. Zurashvili, J. Putkaradze, L. Bakuridze Georgian Minerals in Modern Pharmaceutical Technologies, Proceedings of the International Scientific-Practical Conference, "Innovative Technologies and Modern Materials" Akaki Tsereteli State University, Kutaisi, 2010, 275- 276.

M. Giorgobiani, B. Zurashvili, L. Bakuridze, Al. Bakuridze, J. Putkaradze, Global Pollution and Prospects for the use of modern means of strengthening the body's adaptive mechanisms, Experimental and Clinical Medicine, 3, 2014, 10-12.

M. Giorgobiani, A. Kochlamazashvili, A. Orkosnelli, Combined use of Dioscoride and Geomin during dyslipidemia, Experimental and Clinical Medicine, N2, 2017, p. 74-76.

M. Giorgobiani, T. Shengelia, L. Giorgobiani, L. Bakuridze. Perspectives on the use of Geomin Forte in sports medicine, Materials of the International Congress of the Society of Physiologists of Ivane Beritashvili, Tbilisi, Tbilisi, 2019, September 23-25, P. 215-216.

M. Giorgobiani, A. Kochlamazashvili, Combined action of "Status" and "Geomin" drugs in infarction rehabilitation in women, Experimental and Clinical Medicine, 2020, 3, pp. 32-34.