REPARATIVE OSTEOGENESIS IN NORMAL STATE AND UNDER CONDITIONS OF IODINE DEFICIENCY

  • Kovalchuk P. Ye. PhD in Traumatology, Assoc. Professor, Department of Traumatology and Orthopedics, Higher State Educational Establishment of Ukraine «Bukovinian State Medical University», Ukraine
  • Gasko М. V. PhD in Traumatology, Assoc. Professor, Department of Traumatology and Orthopedics, Higher State Educational Establishment of Ukraine «Bukovinian State Medical University», Ukraine
  • Tulyulyuk S. V. Assistant, Department of Traumatology and Orthopedics, Higher State Educational Establishment of Ukraine «Bukovinian State Medical University», Ukraine
  • Shutka V. J. MD, PhD, Assoc. Professor, Department of Urology and Neurosurgery, Higher State Educational Establishment of Ukraine «Bukovinian State Medical University», Ukraine
Keywords: osteogenesis, iodine, deficiency

Abstract

The study presents the results of investigation of iodine deficiency condition on the bone tissue and healing post-traumatic bone defects under conditions of iodine deficiency.
The experimental part of the study was performed on 63 randomized brand albino male rats of 3-month age. Peculiarities of the reparative osteogenesis were studied on the model of a traumatic injury simulated one-type in the proximal meta-diaphysis of the femoral bone irrespective of the experimental conditions in the frontal plane in the form of perforated defect. The defect was made by means of a drill 1mm in diameter.
The results of the study are indicative of a negative effect of iodine deficiency produced on reparative osteogenesis manifested by inhibition of the process and associated with disorders in the formation of osseous regeneration, deterioration of the structural-functional state of the osseous tissue, development of degenerative-necrotic changes in the osseous tissue and epiphyseal cartilage.

References

Автандилов Г.Г. Медицинская морфометрия. Руководство. – М.: Медицина, 1990. – 384 с.

Бруско А. Т. Теореттичні та біологічні аспекти загоєння переломів кісток / А.Т. Бруско // Хірургічне лікування, медична реабілітація, фізіотерапія переломах при переломах кісток та захворюваннях суглобів: міжнар. наук.-практ. конф. з міжнар. уч., 10–11 квітня, 2008p.: тези доп. – Київ– Маньківка, 2008. – С. 14–17.

Гайко Г. В., Бруско А. Т. Теоретические аспекты физиологической и патологической регенерации костей с позиций системных представлений // Журнал НАМН Украины. – 2013. – Том 19, No 4. – С. 471-481

Григоровский В. В. Метаболическая реакция организма и репаративная регенерация кости при инициированном повреждении / В.В. Григоровский, С.М. Магомедов // Ортопед. травматол. – 2000. – No 2. – С. 101–102.

Зміни гормонального стану при ускладненому перебігу репаративного остеосинтезу після множинних та поєднаних переломів довгих кісток / О.О. Коструб, В.О. Литовченко, М.І. Березка [та ін.] // Проблеми остеології. – 2000. – Т. 3, No 4. – С. 35–36.

Danish investigation on iodine intake and thyroid disease Dan Thyr: status and perspectives / P. Laurberg, T. Jorgensen, H. Perrild, L. Ovsen [et al.] // European Journal of Endrinology. – 2006.– Vol. 155. – P. 219–228.

Ren F. L. Efect of selenium and iodine deficiency on bone, cartilage growth plate and chondrocyte differentiation in two generations of rats / F.L. Ren R.X. Guo //Osteoarthritis Cartilage. – 2007. – Vol. 15.– P. 1171–1177.

Visser T. J. The elemental impotance of ufficient iodine intake / T.J. Visser // Endocrinology. – 2006. – Vol. 147, No 5. – P. 4039–4045.

Thyroid status during skeletal development determines adult bone structure and mineralization / K. Basset, K. Nordstrom, A. Boyde [et.al.] // Mol Endocrinology. – 2007.– Vol. 21, No 8. – P. 1893–1904.

Volzke H. Association Between Serum Insulin-Like Growth Factor I Levels and Thyroid Disorders in a Population-Based Study / H. Volzke // J. Of Clinical Endocrinology & Metabolism. – 2007. – Vol. 92, No 10. – P. 4039–4045.

Views:

224

Downloads:

186

Published
2019-08-31
Citations
How to Cite
Kovalchuk P. Ye., Gasko М. V., Tulyulyuk S. V., & Shutka V. J. (2019). REPARATIVE OSTEOGENESIS IN NORMAL STATE AND UNDER CONDITIONS OF IODINE DEFICIENCY. World Science, 2(8(48), 11-13. https://doi.org/10.31435/rsglobal_ws/31082019/6630