REPARATIVE OSTEOGENESIS IN NORMAL STATE AND UNDER CONDITIONS OF IODINE DEFICIENCY
Abstract
The study presents the results of investigation of iodine deficiency condition on the bone tissue and healing post-traumatic bone defects under conditions of iodine deficiency.
The experimental part of the study was performed on 63 randomized brand albino male rats of 3-month age. Peculiarities of the reparative osteogenesis were studied on the model of a traumatic injury simulated one-type in the proximal meta-diaphysis of the femoral bone irrespective of the experimental conditions in the frontal plane in the form of perforated defect. The defect was made by means of a drill 1mm in diameter.
The results of the study are indicative of a negative effect of iodine deficiency produced on reparative osteogenesis manifested by inhibition of the process and associated with disorders in the formation of osseous regeneration, deterioration of the structural-functional state of the osseous tissue, development of degenerative-necrotic changes in the osseous tissue and epiphyseal cartilage.
References
Автандилов Г.Г. Медицинская морфометрия. Руководство. – М.: Медицина, 1990. – 384 с.
Бруско А. Т. Теореттичні та біологічні аспекти загоєння переломів кісток / А.Т. Бруско // Хірургічне лікування, медична реабілітація, фізіотерапія переломах при переломах кісток та захворюваннях суглобів: міжнар. наук.-практ. конф. з міжнар. уч., 10–11 квітня, 2008p.: тези доп. – Київ– Маньківка, 2008. – С. 14–17.
Гайко Г. В., Бруско А. Т. Теоретические аспекты физиологической и патологической регенерации костей с позиций системных представлений // Журнал НАМН Украины. – 2013. – Том 19, No 4. – С. 471-481
Григоровский В. В. Метаболическая реакция организма и репаративная регенерация кости при инициированном повреждении / В.В. Григоровский, С.М. Магомедов // Ортопед. травматол. – 2000. – No 2. – С. 101–102.
Зміни гормонального стану при ускладненому перебігу репаративного остеосинтезу після множинних та поєднаних переломів довгих кісток / О.О. Коструб, В.О. Литовченко, М.І. Березка [та ін.] // Проблеми остеології. – 2000. – Т. 3, No 4. – С. 35–36.
Danish investigation on iodine intake and thyroid disease Dan Thyr: status and perspectives / P. Laurberg, T. Jorgensen, H. Perrild, L. Ovsen [et al.] // European Journal of Endrinology. – 2006.– Vol. 155. – P. 219–228.
Ren F. L. Efect of selenium and iodine deficiency on bone, cartilage growth plate and chondrocyte differentiation in two generations of rats / F.L. Ren R.X. Guo //Osteoarthritis Cartilage. – 2007. – Vol. 15.– P. 1171–1177.
Visser T. J. The elemental impotance of ufficient iodine intake / T.J. Visser // Endocrinology. – 2006. – Vol. 147, No 5. – P. 4039–4045.
Thyroid status during skeletal development determines adult bone structure and mineralization / K. Basset, K. Nordstrom, A. Boyde [et.al.] // Mol Endocrinology. – 2007.– Vol. 21, No 8. – P. 1893–1904.
Volzke H. Association Between Serum Insulin-Like Growth Factor I Levels and Thyroid Disorders in a Population-Based Study / H. Volzke // J. Of Clinical Endocrinology & Metabolism. – 2007. – Vol. 92, No 10. – P. 4039–4045.
Views:
224
Downloads:
187
Copyright (c) 2019 The authors
This work is licensed under a Creative Commons Attribution 4.0 International License.
All articles are published in open-access and licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0). Hence, authors retain copyright to the content of the articles.
CC BY 4.0 License allows content to be copied, adapted, displayed, distributed, re-published or otherwise re-used for any purpose including for adaptation and commercial use provided the content is attributed.
