THE USE OF THE PRP THERAPY TO ACTIVATE FOLLICULOGENESIS IN WOMEN OF THE LATE REPRODUCTIVE AGE IN PROGRAMS OF ASSISTED REPRODUCTIVE TECHNOLOGIES

Uliana Dorofeieva; Oleksandra Boichuk

doi:10.31435/rsglobal_ws/30042021/7538

Uliana Dorofeieva postgraduate student at the Subdepartment of Obstetrics and Gynecology of the Department of Postgraduate Studies of Ivano-Frankivsk National Medical University
Oleksandra Boichuk MD, professor at the Subdepartment of Obstetrics and Gynecology of the Department of Postgraduate Studies of Ivano-Frankivsk National Medical University

DOI: https://doi.org/10.31435/rsglobal_ws/30042021/7538

Keywords: infertility, late reproductive age, folliculogenesis, intraovarian PRP injection

Abstract

The rate of infertility in married couples of reproductive age in this country makes up from 10 to 15%, in some regions this value is close to 20% - a
critical level that has a negative impact on demographic figures. The rate of pregnancy depends directly on the women’s age and decreases by 3.3
times starting from the age of 19 and by the age of 48. The decrease in the ability to conceive is accounted for by subtle mechanisms related to the
deterioration of the quality of oocytes. The patients who are prepared for an extracorporeal fertilization program (ECF) and do not respond to
controlled ovarian hyperstimulation protocols are considered to be poor respondents. Many studies focused on the development of an optimal
treatment method. However, none of the approaches seems to be effective enough to guarantee a successful use. Platelet-rich plasma is a new and
promising method that is successfully used in the reproductive science to solve a number of medical problems. All the patients whose common
features were low oocyte output and poor embryo quality as well as failed ECF attempts were offered a treatment method of autologous PRP therapy
after their written consent. Three months later, one obtained astonishing results, which by the markers of biochemical infertility alone could be
classified as a complete biological phenomenon and are also characterized by improved embryo quality. The results of hormonal homeostasis show a
decrease in the level of the follicle-stimulating hormone by 67.33% while the level of the anti-muellerian hormone is 75.18% higher.
Thus, the use of the PRP therapy in poor respondents helps them to overcome their problematic reproductive barrier.

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