CHANGES IN THE HAEMOSTASIS SYSTEM OF PATIENTS WITH ALCOHOLIC CIRRHOSIS OF THE LIVER ASSOCIATED WITH NON-ALCOHOLIC FATTY LIVER DISEASE

Nataliia Matkovska

doi:10.31435/rsglobal_ws/30062019/6572

Nataliia Matkovska Assosiate Professor, Ukraine, Ivano-Frankivsk, Ivano-Frankivsk National Medical University; Department of Therapy and Family Practice of postgraduate study faculty

DOI: https://doi.org/10.31435/rsglobal_ws/30062019/6572

Keywords: alcoholic liver disease, non-alcoholic fatty liver disease, hemostasis

Abstract

The purpose of the research was to study the changes in haemostatic system in patients with alcohol liver disease (ALD) associated with NAFLD. The decrease in the synthetic function of the liver and the development of hypersensitivity syndrome in patients with ALC in combination with NAFLD is accompanied by more pronounced changes in the various parts of the haemostasis of the corresponding Child-Pugh class, which manifests itself in the decrease in the number of blood corpuscles, PI levels, and growth of indicators for D-dimers, INR, Von Willebrand factor, PT, TT, APTT. Such changes lead to hypo- and hypercoagulation states, which may be accompanied by complications such as thrombosis and bleeding.

References

Intagliata NM, Davis JPE, Caldwell SH. Coagulation Pathways, Hemostasis, and Thrombosis in Liver Failure. Semin Respir Crit Care Med 2018; 39:598.

Bos S, van den Boom B, Kamphuisen PW, Adelmeijer J, Blokzijl H, Schreuder T, Lisman T. Haemostatic profiles are similar across all aetiologies of cirrhosis. Thromb Haemost. 2019; 119 (2): 246-253.

Vinholt PJ, Hvas AM, Nielsen C, Söderström AC, Sprogøe U, Fialla AD, Nybo M. Reduced platelet activation and platelet aggregation in patients with alcoholic liver cirrhosis. Platelets. 2018 Jul; 29 (5): 520-527.

Тугушев А. С., Михантьев Д. И., Нешта В. В., Черковская О. С., Рязанова Е. Д. Коррекция системы гемостаза у больных циррозом печени. Запорожский медицинский журнал. 2015. №5 (92): 45-47.

Potze W, Siddiqui MS, Boyett SL, Adelmeijer J, Daita K, Sanyal AJ, Lisman T. Preserved hemostatic status in patients with non-alcoholic fatty liver disease. J Hepatol. 2016 Nov; 65(5): 980-987.

Anna K. Kopec, Nikita Joshi, James P. Luyendyk. Role of hemostatic factors in hepatic injury and disease: Animal models de-liver. J Thromb Haemost. 2016 Jul; 14 (7): 1337-1349.

Kalambokis GN, Oikonomou A, Christou L et al. Von Willebrand factor and procoagulant imbalance predict outcome in patients with cirrhosis and thrombocytopenia. J Hepatol. 2016; 65: 921.

Yilmaz, VT, Dincer D, Avci AB, Cetinkaya R. Significant Association between Serum Levels of von Willebrand Factor (vWF) Antigen with Stages of Cirrhosis. The Eurasian Journal of Medicine. 2015; 47(1): 21-25.

Hugenholtz GC, Macrae F, Adelmeijer J, et al. Procoagulant changes in fibrin clot structure in patients with cirrhosis are associated with oxidative modifications of fibrinogen. J Thromb Haemost 2016; 14: 1054.

Fisher C, Patel VC, Stoy SH et al. Balanced haemostasis with both hypo- and hyper-coagulable features in critically ill patients with acute-on-chronic-liver failure. J Crit Care. 2018; 43: 54.

Intagliata NM, Argo CK, Stine JG et al. Concepts and Controversies in Haemostasis and Thrombosis Associated with Liver Disease: Proceedings of the 7th International Coagulation in Liver Disease Conference. J Thromb Haemost. 2018; 118: 1491.

Blasi A, Calvo A, Prado V, et al. Coagulation Failure in Patients With Acute-on-Chronic Liver Failure and Decompensated Cirrhosis: Beyond the International Normalized Ratio. Hepatology 2018; 68:2325.

Хурум З. Ю., Кулбужева М. И., Кончакова А. А. Кровотечение из варикозно-расширенных вен пищевода при циррозе печени. Кубанский научный медицинский вестник. 2017. №2 (163): 135-138.

Budimir I, Gradišer M, Nikolić M, Baršić N, Ljubičić N, Kralj D, Budimir I Jr. Glasgow Blatchford, preendoscopic Rockall and AIMS65 scores show no difference in predicting rebleeding rate and mortality in variceal bleeding. Scand J Gastroenterol. 2016 Nov; 51 (11): 1375-9.

Bos S, Potze W, Siddiqui MS, Boyett SL, Adelmeijer J, Daita K, Lisman T, Sanyal AJ. Changes of in vitro potency of anticoagulant drugs are similar between patients with cirrhosis due to alcohol or nonalcoholic fatty liver disease. Thromb Res. 2017 Feb; 150: 41-43.

Potze W, Siddiqui MS, Sanyal AJ. Vascular Disease in Patients with Nonalcoholic Fatty Liver Disease. Semin Thromb Hemost. 2015 Jul; 41 (5): 488-93.

Stine JG, Niccum BA, Zimmet AN et al. Increased risk of venous thromboembolism in hospitalized patients with cirrhosis due to non-alcoholic steatohepatitis. Clin Transl Gastroenterol. 2018; 9: 140.