ЗМІНА СТАНУ КОМПЛЕКСУ ЛЕГЕНЕВОГО СУРФАКТАНТУ ПРИ ВТРУЧАННЯХ З ПРИВОДУ ГОСТРОГО АОРТАЛЬНОГО СИНДРОМУ В УМОВАХ ШТУЧНОГО КРОВООБІГУ
Abstract
Objective. To study changes in the state of pulmonary surfactant complex during interventions in acute aortic syndrome. Materials and methods. Biochemical analysis and cytological study were conducted on 142 samples obtained during the bronchoalveolar lavage performed intraoperatively or in the early postoperative period. Results. It was determined that in the postoperative period the bronchoalveolar fluid of patients with disorders of gas exchange contained significantly more general protein, albumin and fibrinogen, indicating an increase in the alveolar membrane transport. The higher content of plasma proteins in the alveolar fluid of patients with ARDS was due to low phospholipid content, reflecting damage to the lung surfactant system. Conclusion. The obtained data indicates the damage of pulmonary surfactant complex followed by an increase in the alveolar membrane transport leading to development of acute respiratory distress syndrome after surgery on the aorta.
References
Belov YV, Komarov RN, Stepanenko AB, Gasanov A.F. Legochno-plevral'nye oslozhnenija pri hirurgicheskom lechenii zabolevanij nishodjashhego otdela grudnoj aorty. Hirurgiya. Journal Pirogov N.I. 2013; 11: p. 16–19. [in Russian]
Wang J, Bian J, Wan X, Zhu KM, Sun ZZ, Lu AD Association between inflammatory genetic polymorphism and acute lung injury after cardiac surgery with cardiopulmonary bypass. Med Sci Monit. 2010; 16: 260 PMID:20424554; published May 2010
Guérin C Prone ventilation in acute respiratory distress syndrome. Eur Respir Rev. 2014; 23: 249 – 257 PMID: 24881080, DOI:10.1183/09059180.00001114;
Taut FJ, Rippin G, Schenk P, Findlay G, Wurst W, Häfner D, et al. А Search for subgroups of patients with ARDS who may benefit from surfactant replacement therapy: a pooled analysis of five studies with recombinant surfactant protein-C surfactant (Venticute). Chest. 2008; 134: 724 – 732 PMID:18689599, DOI:10.1378/chest.08-0362;
Esteban A, Frutos-Vivar F, Muriel A. Evolution of mortality over time in patients receiving mechanical ventilation. Am J Respir Crit Care Med. 2013; 188: 220 – 230 PMID:23631814, DOI: 10.1164/rccm.201212-2169OC;
Guérin, C. Prone ventilation in acute respiratory distress syndrome. Eur Respir Rev. 2014; 23: 249 – 257 PMID: 24881080, DOI:10.1183/09059180.00001114;
Vlaar AP, Cornet AD, Hofstra JJ, Porcelijn L, Beishuizen A, Kulik W, et al. The effect of blood transfusion on pulmonary permeability in cardiac surgery patients: a prospective multicenter cohort study. Transfusion. 2012; 52: 82 – 90 DOI: 10.1111/j.1537-2995.2011.03231.x;
Yeremenko AA, Levikov DI, Egorov VM Primenenie neinvazivnoj masochnoj vspomogatel'noj ventiljacii legkih pri ostrom respiratornom distress-sindrome u kardiohirurgicheskih bol'nyh. Anesteziologiya i reanimatologiya. 2004; №5: p.14 – 17 [in Russian]
Kogan A, Preisman S, Levin S, Raanani E, Sternik L Adult respiratory distress syndrome following cardiac surgery. J Card Surg. 2014; 29: 41 – 46 PMID:24299028, DOI:10.1111/jocs.12264; publishe 3rd of December 2013
Fox A., Cooper J. Anesthetic management for thoracic aneurism and dissections. Cardiac anesthesia F. Hensley, D. Martin, G. Gravlee. 4th ed. – Philadelphia: Lippincott Williams and Wilkins. 2008. 653 – 694;
Aggarwal N., King L., D’Alessio F. Diverse macrophage populations mediate acute lung inflammation and resolution. Am. J. Physiol. Lung Cell. Mol. Physiol. 2014; 306: 709 – 725 PMID:24508730, PMCID:PMC3989724, DOI:10.1152/ajplung.00341.2013;
Cornet A.D., Kingma S.D., Trof R.J. Hepatosplanchnic ischemia/reperfusion is a major determinant of lung vascular injury after aortic surgery. J Surg Res. 2009; 157: 48 – 54 PMID:19482316, DOI: 10.1016/j.jss.2008.09.021
Views:
154
Downloads:
163
Copyright (c) 2019 The author
![Creative Commons License](http://i.creativecommons.org/l/by/4.0/88x31.png)
This work is licensed under a Creative Commons Attribution 4.0 International License.
All articles are published in open-access and licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0). Hence, authors retain copyright to the content of the articles.
CC BY 4.0 License allows content to be copied, adapted, displayed, distributed, re-published or otherwise re-used for any purpose including for adaptation and commercial use provided the content is attributed.