ВАСКУЛОЕНДОТЕЛІАЛЬНИЙ ФАКТОР РОСТУ А ТА ПОЛІМОРФІЗМ G634C ГЕНА ВЕФР-A У ХВОРИХ ІНФАРКТОМ МІОКАРДА В ГОСТРИЙ ТА ВІДДАЛЕНИЙ ПЕРІОДИ

Копиця М. П.; Кутя І. М.; Родіонова Ю. В.

doi:10.31435/rsglobal_ws/30082018/6061

Копиця М. П. д. мед. н., Україна, Харків, ДУ «Національний інститут терапії ім. Л.Т. Малої НАМН України»
Кутя І. М. к. мед. н., Україна, Харків, ДУ «Національний інститут терапії ім. Л.Т. Малої НАМН України»
Родіонова Ю. В. Україна, Харків, ДУ «Національний інститут терапії ім. Л.Т. Малої НАМН України»

DOI: https://doi.org/10.31435/rsglobal_ws/30082018/6061

Keywords: Vascular endothelial growth factor A (VEGF-A), acute myocardial infarction ST-elevation STEMI, VEGF-A gene polymorphism (G634C), left ventricle remodeling

Abstract

Vascular endothelial growth factor A (VEGF-A) promotes the survival of endothelial cells during acute myocardial infarction, accelerates the development of collateral blood supply to ischemic myocardium, and affects the size diminishing of the necrotic lesion area. The synthesis of the VEGF- A in response to standard stimuli is different between people that is genetically determined. The aim was to study the association of polymorphous variants of the VEGF-A gene (G634C) with the dynamics of structural and functional parameters of left ventricle in patients with acute ST elevation myocardial infarction (STEMI) during a 6-month period.
A significantly higher VEGF-A concentration was determined in the carriers of the GG genotype compared to the GC genotype (p = 0.047) in the acute period. It has been established that the genotype GC in patients with acute myocardial infarction ST-elevation (STEMI) is associated with more pronounced changes in the left ventricular geometry during the acute period. The GC genotype is associated with a better blood pressure control and a decrease in the left ventricle mass after 6 months’ observation.

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