EXPERIMENTAL SUBSTANTIATION OF ASPECTS OF PATHOGENESIS OF PYO-INFLAMMATORY COMPLICATIONS OF ТHORACOABDOMINAL TRAUMAS
Abstract
The research presents the pathophysiological substantiation of the MODS and early pyo-inflammatory complications formation during early post-traumatic period of severe blunt thoracic and abdominal trauma in experimental rats. The decrease in intestinal oxygen extraction developed as response to trauma, the permeability of the intestinal barrier is disturbed.
It is accompanied by a massive influx of intestinal bacterial endotoxins into the blood, which is manifested by a significant decrease in the concentration of blood plasma Anti-LPS-IgG of rats.
This process is an inducer of cascade immunopathological reactions of the body and launching into a number of pathological circles with the subsequent development of MODS and promotes to the development of early pyo-inflammatory complications.
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