ФУНКЦІОНАЛЬНИЙ СТАН ГУМОРАЛЬНОЇ ЛАНКИ ІМУНІТЕТУ ПРИ ТРАВМАТИЧНІЙ ХВОРОБІ У ПАЦІЄНТІВ З ПІДВИЩЕНИМ ІНДЕКСОМ МАСИ ТІЛА

Кучерявченко В. В.; Волкова Ю. В.; Шарлай К. Ю.

doi:10.31435/rsglobal_ws/30042019/6473

Кучерявченко В. В. к. мед. н., Україна, Харків, Харківський національний медичний університет кафедра медицини невідкладних станів, анестезіології та інтенсивної терапії
Волкова Ю. В. проф., д. мед. н., Україна, Харків, Харківський національний медичний університет кафедра медицини невідкладних станів, анестезіології та інтенсивної терапії
Шарлай К. Ю. к. мед. н., Україна, Харків, Харківський національний медичний університет кафедра медицини невідкладних станів, анестезіології та інтенсивної терапії

DOI: https://doi.org/10.31435/rsglobal_ws/30042019/6473

Keywords: humoral immunity, traumatic disease, increased body mass index, systemic multivariate analysis

Abstract

The aim of our work was to analyze the functional state of the humoral immunity in traumatic disease in patients with an increased body mass index (IBMI). Using the systemic multivariate analysis, the integral indices of the B-system of immunogenesis were determined on the basis of a dynamic study of 1344 complex immunograms in 224 patients with IBMI with polytrauma with different starting figures for BMI in the period 1 day to 1 year from the moment of injury. Patients were divided into 3 groups depending on the starting BMI figures. It was revealed that changes in humoral processes in traumatic disease in patients with IBMI persist for a long time; the degree of damage to the B-system and the orientation of the reactions in the examined patients are of a similar nature; the manifestations and adequacy of the compensation processes and the severity of the acquired pathology of this subsystem depend on the patient's BMI, since the initial integral indicators in the comparison groups did not differ much.

References

Gray, S., Dieudonne, B. (2018). Optimizing Care for Trauma Patients with Obesity. Cureus, 10(7), 2130.

Winfield, R.D., Southard, R.E., Turnbull, I.R., Bochicchio, K., Reese, S., Freeman, B.D., Bochicchio, G.V. (2015). Angiotensin Inhibition Is Associated with Preservation of T-Cell and Monocyte Function and Decreases Multiple Organ Failure in Obese Trauma Patients. J Am Coll Surg, 221(2), 486-494.

Kornblith, L.Z., Howard, B., Kunitake, R. (2015). Obesity and clotting: Body mass index independently contributes to hypercoagulability after injury. J Trauma Acute Care Surg, 78(1), 30-36.

Chuang, J.F., Rau, C.S., Kuo, P.J. Traumatic injuries among adult obese patients in southern Taiwan: a cross-sectional study based on a trauma registry system. BMC Public Health, 16, 275-279.

Majdan, M., Brazinova, A., Wilbacher, I., Rusnak, M., Mauritz, W. (2015). The impact of body mass index on severity, patterns and outcomes after traumatic brain injuries caused by low level falls. Eur J Trauma Emerg Surg, 41(6), 651–656.

Premaor, M.O., Comim, F.V., Compston, J.E. (2014). Obesity and fractures. Arq Bras Endocrinol Metabol, 58(5), 470–477.

Dhungel, V., Liao, J., Raut, H., Lilienthal, M.A., Garcia, L.J., Born, J., Choi, K.C. (2015). Obesity delays functional recovery in trauma patients. J Surg Res, 193 (1), 415–420.

Osborne, Z., Rowitz, B., Moore, H., Oliphant, U., Butler, J., Olson, M., Aucar, J. (2014). Obesity in trauma: outcomes and disposition trends. Am J Surg, 207(3), 387–392.