SOMATIC AND PSYCHOLOGICAL COMPLICATIONS OF OBESITY IN THE PEDIATRIC POPULATION : CONTEMPORARY CHALLENGES FOR CLINICAL PRACTICE – A SYSTEMATIC REVIEW
Abstract
Obesity in children is a pandemic of the 21st century. It is a clinically significant problem and one of the most alarming health issues observed in children worldwide. Overweight and obesity result from the interaction of environmental, genetic, iatrogenic and endocrine factors, and their consequences significantly affect overall quality of life. Over the past few decades, it has been shown that obesity in young people influences the future development of diseases such as metabolic, respiratory, cardiovascular, endocrine and psychosocial disorders. This article focuses on the consequences of obesity in children and adolescents, including hypertension, obstructive sleep apnoea, insulin resistance, type 2 diabetes, dyslipidaemia, NAFLD, endocrine disturbances such as premature puberty or PCOS, and a range of mental health issues. We summarise the most important short- and long-term effects of obesity in children and adolescents and highlight the importance of early diagnosis and a multidisciplinary therapeutic approach to prevent short- and long-term complications.
References
Badr M, El-Rabaa G, Freiha M, Kedzia A and Niechciał E (2025) Endocrine consequences of childhood obesity: a narrative review. Front. Endocrinol. 16:1584861. doi: 10.3389/fendo.2025.1584861,
Brady TM (2017) Obesity-Related Hypertension in Children. Front. Pediatr. 5:197. doi: 10.3389/fped.2017.00197,
Di Sessa, A.; Guarino, S.; Umano, G.R.; Arenella, M.; Alfiero, S.; Quaranta, G.; Miraglia del Giudice, E.; Marzuillo, P. MAFLD in Obese Children: A Challenging Definition. Children 2021, 8, 247. https:// doi.org/10.3390/children8030247,
Drozdz, D.; Alvarez-Pitti, J.; Wójcik, M.; Borghi, C.; Gabbianelli, R.; Mazur, A.; Herceg-Cavrak, V.; ˇ Lopez-Valcarcel, B.G.; Brzeziński, M.; Lurbe, E.; et al. Obesity and Cardiometabolic Risk Factors: From Childhood to Adulthood. Nutrients 2021, 13, 4176. https://doi.org/ 10.3390/nu13114176,
Goel A, Reddy S, Goel P (July 20, 2024) Causes, Consequences, and Preventive Strategies for Childhood Obesity: A Narrative Review. Cureus 16(7): e64985. DOI 10.7759/cureus.64985,
Kansra AR, Lakkunarajah S and Jay MS (2021) Childhood and Adolescent Obesity: A Review. Front. Pediatr. 8:581461. doi: 10.3389/fped.2020.581461
Kishimoto I. Subclinical Reactive Hypoglycemia with Low Glucose Effectiveness-Why We Cannot Stop Snacking despite Gaining Weight. Metabolites. 2023 Jun 15;13(6):754. doi: 10.3390/metabo13060754. PMID: 37367911; PMCID: PMC10304473,
Maggio et al.: Medical and non-medical complications among children and adolescents with excessive body weight. BMC Pediatrics 2014 14:232. doi:10.1186/1471-2431-14-232,
Mazur A, Molna´r D, Gawlik AM, Telega G, Vlachopapadopoulou E and Wojcik M (2023) Editorial: Endocrine and metabolic consequences of childhood obesity, volume II. Front. Endocrinol. 14:1239914. doi: 10.3389/fendo.2023.1239914,
Mazur, A.; Zachurzok, A.; Baran, J.; Dere ´n, K.; Łuszczki, E.; Weres, A.; Wyszy ´nska, J.; Dylczyk, J.; Szczudlik, E.; Drozdz, D.; et al. Childhood Obesity: Position Statement of Polish Society of Pediatrics, Polish Society for Pediatric Obesity, Polish Society of Pediatric Endocrinology and Diabetes, the College of Family Physicians in Poland and Polish Association for Study on Obesity. Nutrients 2022, 14, 3806. https:// doi.org/10.3390/nu14183806,
Mostafa Salama, Babu Balagopal, Ilene Fennoy, Seema Kumar, Childhood Obesity, Diabetes, and Cardiovascular Disease Risk, The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 12, December 2023, Pages 3051–3066, https://doi.org/10.1210/clinem/dgad361,
Narang, Indra, Mathew, Joseph L., Childhood Obesity and Obstructive Sleep Apnea, Journal of Nutrition and Metabolism, 2012, 134202, 8 pages, 2012. https://doi.org/10.1155/2012/134202,
Pervanidou, P., Charmandari, E. & Chrousos, G.P. Endocrine Aspects of Childhood Obesity. Curr Pediatr Rep 1, 109–117 (2013). https://doi.org/10.1007/s40124-013-0011-y,
Rahman, S. A., Hossain, M., & Begum, S. (2018). Dyslipidemia in Childhood Obesity: A Review. Bangladesh Journal of Child Health, 42(3), 148–154. https://doi.org/10.3329/bjch.v42i3.39270,
Savino A, Pelliccia P, Chiarelli F, Mohn A. Obesity-related renal injury in childhood. Horm Res Paediatr. 2010;73(5):303-11. doi: 10.1159/000308161. Epub 2010 Apr 14. PMID: 20389099,
Shaban Mohamed, M.A.; AbouKhatwa, M.M.; Saifullah, A.A.; Hareez Syahmi, M.; Mosaad, M.; Elrggal, M.E.; Dehele, I.S.; Elnaem, M.H. Risk Factors, Clinical Consequences, Prevention, and Treatment of Childhood Obesity. Children 2022, 9, 1975. https://doi.org/10.3390/children9121975,
Sliwowska JH, Wojcik M, El Ghoch M and Delvecchio M (2023) Editorial: Metabolic consequences in children and adolescents with obesity: latest insights. Front. Endocrinol. 14:1223129. doi: 10.3389/fendo.2023.1223129,
Ullah MI, Tamanna S. Obesity: Clinical Impact, Pathophysiology, Complications, and Modern Innovations in Therapeutic Strategies. Medicines. 2025; 12(3):19. https://doi.org/10.3390/medicines12030019,
Umekar S, Joshi A. Obesity and Preventive Intervention Among Children: A Narrative Review. Cureus. 2024 Feb 20;16(2):e54520. doi: 10.7759/cureus.54520. PMID: 38516445; PMCID: PMC10955407,
Vlachopapadopoulou E, Mazur A, Gawlik AM, Telega G, Wojcik M, and Molna´r D (2025). Editorial: Endocrine and metabolic consequences of childhood obesity, volume III. Front. Endocrinol. 16:1546470. doi: 10.3389/fendo.2025.1546470.
Copyright (c) 2025 Idalia Myszor, Michał Madej, Maria Kubacka, Lucjan Kocemba, Gabriela Mroczka, Sylwia Nycz-Jucha, Paulina Łobaza, Brygida Pinkowicz, Piotr Rachwał, Barbara Nowak-Misiąg
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