THE IMPACT OF COFFEE CONSUMPTION ON HUMAN HEALTH: A REVIEW OF SCIENTIFIC EVIDENCE
Abstract
The purpose of this review is to present the current state of knowledge on the impact of coffee consumption on human health, with particular emphasis on its bioactive components and physiological effects. The method for the scientific literature review involved were the various systematic analyses, meta-analyses, and also the reports of global public health institutions like the European Food Safety Authority (EFSA) [7], the World Health Organization (WHO) [19], and the American College of Obstetricians and Gynecologists (ACOG) [1].
The theoretical section discusses the chemical composition of coffee, including caffeine, polyphenols, chlorogenic acids, and diterpenes, as well as their mechanisms of action on the nervous, metabolic, and cardiovascular systems. The review indicates that moderate coffee consumption (approximately two to four cups per day) is associated with a lower risk of type 2 diabetes, Parkinson’s disease, certain cancers, and reduced all-cause mortality [15][5]. Yet, overconsumption can cause sleep disorders, anxiety, acid reflux, and high blood pressure in people who are easily affected. Besides that, the review also points to factors that influence the impact of coffee on the body, such as the genetics of caffeine metabolism and the ways of preparation. Finally, it is stated that moderate consumption of coffee, particularly filtered, can be a safe practice and even have a positive effect on health. The main factors deciding this are the amount of coffee, the individual's tolerance, and the general dietary and lifestyle context.
References
American College of Obstetricians and Gynecologists. (2020). Moderate caffeine consumption during pregnancy (ACOG Committee Opinion No. 462). https://www.acog.org
Butt, M. S., & Sultan, M. T. (2011). Coffee and its consumption: Benefits and risks. Critical Reviews in Food Science and Nutrition, 51(4), 363-373. https://doi.org/10.1080/10408390903586412
Cornelis, M. C., El-Sohemy, A., Kabagambe, E. K., & Campos, H. (2006). Coffee, CYP1A2 genotype, and risk of myocardial infarction. JAMA, 295(10), 1135-1141. https://doi.org/10.1001/jama.295.10.1135
Costa, J., Lunet, N., Santos, C., Santos, J., & Vaz-Carneiro, A. (2010). Caffeine exposure and the risk of Parkinson’s disease: A systematic review and meta-analysis of observational studies. Journal of Alzheimer’s Disease, 20(S1), S221-S238. https://doi.org/10.3233/JAD-2010-091525
Ding, M., Bhupathiraju, S. N., Chen, M., van Dam, R. M., & Hu, F. B. (2014). Caffeinated and decaffeinated coffee consumption and risk of type 2 diabetes: A systematic review and a dose-response meta-analysis. Diabetes Care, 37(2), 569-586. https://doi.org/10.2337/dc13-1203
Drake, C., Roehrs, T., Shambroom, J., & Roth, T. (2013). Caffeine effects on sleep taken 0, 3, or 6 hours before going to bed. Journal of Clinical Sleep Medicine, 9(11), 1195-1200. https://doi.org/10.5664/jcsm.3170
European Food Safety Authority. (2015). Scientific opinion on the safety of caffeine. EFSA Journal, 13(5), 4102. https://doi.org/10.2903/j.efsa.2015.4102
Fredholm, B. B., Battig, K., Holmen, J., Nehlig, A., & Zvartau, E. E. (1999). Actions of caffeine in the brain with special reference to factors that contribute to its widespread use. Pharmacological Reviews, 51(1), 83-133.
Grosso, G., Godos, J., Galvano, F., & Giovannucci, E. L. (2017). Coffee, caffeine, and health outcomes: An umbrella review. Annual Review of Nutrition, 37, 131-156. https://doi.org/10.1146/annurev-nutr-071816-064941
International Agency for Research on Cancer. (2018). Coffee, mate and very hot beverages. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans (Vol. 116). World Health Organization.
Loftfield, E., Cornelis, M. C., Caporaso, N., Yu, K., Sinha, R., & Freedman, N. D. (2018). Association of coffee drinking with mortality by genetic variation in caffeine metabolism: Findings from the UK Biobank. JAMA Internal Medicine, 178(8), 1086-1097. https://doi.org/10.1001/jamainternmed.2018.2425
Mostofsky, E., Rice, M. S., Levitan, E. B., & Mittleman, M. A. (2016). Habitual coffee consumption and risk of heart failure: A dose–response meta-analysis. Circulation: Heart Failure, 5(4), 401405. https://doi.org/10.1161/CIRCHEARTFAILURE.112.967299
Myers, M. G. (1998). Caffeine and cardiac arrhythmias. American Journal of Medicine, 105(1), 94-99. https://doi.org/10.1016/S0002-9343(98)00096-9
Nehlig, A. (2016). Effects of coffee/caffeine on brain health and disease: What should I tell my patients? Practical Neurology, 16(2), 89-95. https://doi.org/10.1136/practneurol-2015-001162
Poole, R., Kennedy, O. J., Roderick, P., Fallowfield, J. A., Hayes, P. C., & Parkes, J. (2017). Coffee consumption and health: Umbrella review of meta-analyses of multiple health outcomes. BMJ, 359, j5024. https://doi.org/10.1136/bmj.j5024
Urgert, R., & Katan, M. B. (1997). The cholesterol-raising factor from coffee beans. Annual Review of Nutrition, 17, 305-324. https://doi.org/10.1146/annurev.nutr.17.1.305
UK Biobank. (2022). Coffee consumption and risk of cardiovascular disease and mortality: A large prospective cohort study. European Journal of Preventive Cardiology, 29(8), 1107-1116. https://doi.org/10.1093/eurjpc/zwab157
World Cancer Research Fund / American Institute for Cancer Research. (2018). Diet, nutrition, physical activity and cancer: A global perspective. Continuous Update Project Expert Report.
World Health Organization. (2020). Diet, nutrition and the prevention of chronic diseases (WHO Technical Report Series No. 916). World Health Organization.
Zentgraf, R., Buettner, A., & Bohn, T. (2012). Coffee consumption and gastroesophageal reflux disease: A critical review. European Journal of Nutrition, 51(7), 813-821. https://doi.org/10.1007/s00394-012-0388-9
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