ASCORBIC ACID AND THE FORMATION OF NITRIC OXIDE IN HUMAN LEUKOCYTES

  • T. T. Zhumabaeva Osh State University
  • Z. V. Kuropteva Institute of biochemical physics, Russian Academy of Sciences, Moscow
  • Zh. T. Moldaliev Osh State University https://orcid.org/0000-0001-5525-7629
Keywords: Ascorbic acid, leukocyte, EPR spectra, nitrozyl complexes of hem proteins, nitroxide synthases (NOS), the formation of nitric oxide

Abstract

Ascorbic acid is involved in the formation of nitrogen oxide in leukocytes of humans and animals. It is an important role of the AA in maintaining the immune status of the organism.

References

Enstrom J.E. Vitamin C in prospective epidemiological studies. In Vitamin C in Health and Diseases (Packer L., and Fuchs G., eds). 1997. P.381-389, Marcel Dekker, Inc., New York.

Vinson J.A., Hu Shen-Ju, Jung Synah, Stanski A.M. A citrus extract plus AA decreases Lipids, lipid peroxdes, lipoprotein oxidative susceptibility, and atherosclerosis in hypercholes terolemic hamsters // J.Agr. and Food Chem. 1998. V.46. N4. P.1453-1459.

Carr A., Frei B. Does vitamin C act as a pro-oxidant under physiological conditions? // The FASEB J. 1999. V.13. P.1007-1024.

Levine M. New concepts in the biology and biochemistry of ascorbic acid. // N.Engl.J.Med. V.314, P.892-902, 1986.

Halliwel B. Vitamin C: antioxidant or pro-oxidant in vivo? // Free Rad. Res. 1996. V.25. P.439-454.

Burns J.J. Missing step in man, monkey and guinea pig required for the biosynthesis of ascorbic acid. // Nature, 1957. v.180, p.553.

Rose R.C. Transport of ascorbic acid and other water-soluble vitamins // Biochim. Biophys Acta. 1988. V. 947. P. 335-366.

Beyur A. Separation of leucocytes from blood and bone marrow // Scand. J. Clin. Lab. Invest. 1968. V.21. Suppl. P.9713. Pauling L. Vitamin C and the Common Cold. San Francisco, California. 1970. Stone I.The Healing Factor, Vitamin C Against Disease, Grosset and Dunlap, New York. 1972.

Louro S.R.W., Ribeiro P.C., Bemski G. EPR spectral changes of nitrosyl hemes and their relation to the hemoglobin T-R transition // Biоhimica and Biophysica Acta. 1981. V.670. N 1. P.56-63.

Szabo A., Perutz M.F. Equilibrium between Six- and Fife-Coordinated Hemes in Nitrosyl-hemoglobin: Interpretation of ESR Spectra // Biochem. 1976. V. 15, N 20. P. 4427-4428.

Moncada, S., Palmer, R.M.J., Higgs, E.A. Nitric oxide: physiology, pathophysiology and pharmacology. // Pharmacol. Rev., 1991. V.43. P.109-142.

Hebel J.M.., Marletta M.A. Macrophage nitric oxide synthase: relationship between enzyme-bound tetrahydrobiopterin and synthase activity // Biochemistry. 1992. V.31. P.7160-7165.

Schmidt H.H.H.W., Hofmann H., Ogilvie P. // The role of nitric oxide in physiology and pathophysiology. B.; Heidelberg: Springer, 1995. P.75-86.

Bredt D.S. et al. Cloned and expressed nitric oxide synthase structurally resembles cytochrome H-450 reductase.// Nature. 1991. V.351. P.714-718.

Knowles R.G., Moncada S. Nitric oxide synthases in mammals // Biochem. J. 1994. V.298. P.249-258.

Mayer B., John M., Heinzel B., et al. Brain nitric oxide synthase is a biopterin – and flavin-containing multi-functional oxide-reductase // FEBS Lett. 1991. V.288. P.187-191.

Feldman P.L., Griffith O.W., Stuehr D.J. The surprising life of nitric oxide.// C.I. E. N. 1993. Dtc.20. P.26-36.

Heinrich P.C., Castell J.V., Andus T. Interleukin-6 and the acute phase response // Biochem. J., 1990, V.265. P.621-636].

Жумабаева Т.Т., Байдер Л.М., Куроптева З.В. Высвобождение ионов железа из трансферрина под действием оксида азота. // Биофизика, 2000, Т.45, В.4, С.712-715

Levine M. New concepts in the biology and biochemistry of ascorbic acid. // N.Engl.J.Med. V.314, P.892-902, 1986

Девис М., Остин Ж., Патридж Д. Витамин С. Химия и биохимия. М. «Мир».1999. с.99.

Куроптева З.В., Жумабаева Т.Т., Байдер Л.М., Володина Л.А. Аскорбиновая кислота и продуцирование оксида азота в E. Coli. // ДАН РАН, 2000, Т.374. № 4. С.552-554.

Hibbs J. B. Jr., Vavrin Z. Taintor R.R. L-arginine is required for expression of the activated macrophage effector mechanism causing selective metabolic inhibition in target cells.// J. Immunol., 1987. V. 138. №2. P. 550-565.

Hibbs J.D., Taintor R.r., Vavrin Z. Macrophage cytotoxicity: role for L-arginine deiminase and imido nitrogen oxidation to nitrite. // Sciences. 1987. V.235, P.478-486.

Weitzberg E., Lundberg J.O.N. Nonenzymatic nitric oxide production in humans. // Nitric oxide: Biology and Chemistry. 1998. V.2. N2. P. 1-7.

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Published
2019-02-28
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How to Cite
T. T. Zhumabaeva, Z. V. Kuropteva, & Zh. T. Moldaliev. (2019). ASCORBIC ACID AND THE FORMATION OF NITRIC OXIDE IN HUMAN LEUKOCYTES. World Science, 1(2(42), 42-45. https://doi.org/10.31435/rsglobal_ws/28022019/6352