CLINICAL AND LABORATORY PREDICTORS OF LATENT HERPESVIRUS INFECTION IN CHILDREN WITH ROTAVIRUS GASTROENTERITIS
Abstract
To achieve the aim there has been examined 104 children aged 1–3 years with moderate and severe forms of intestinal infection of rotavirus etiology, for which they received appropriate treatment in Kharkiv Regional Children's Infectious Diseases Clinical Hospital. Patients were divided into 2 groups: 1 group — 33 children with no concomitant herpesvirus, and 2 groups — 71 patients with rotavirus gastroenteritis and latent herpesvirus infection, caused by cytomegalovirus, Epstein-Barr virus or human herpes virus 6. Children in examined groups were comparable by gender, age, severity of main disease and other parameters.
Prognosis of latent herpesvirus infection was made by means of multiple binomial regression. Independent predictors of concomitant herpesvirus infection included maximal daily number of vomiting, maximal increase of body temperature, time of onset of catarrhal symptoms since beginning of disease, level of ketone bodies in urine, amount of leukocytes, rod-shaped neutrophils and eosinophils in common blood count during acute phase of disease. As a reference group, we used respective clinical and paraclinical indices of patients with rotavirus infection only. Accuracy of model is 81.73 %.
References
L.M. Boyarska, O.V. Usachova, T.S. Gerasimchuk et al (2014). Kliniko-Imunologichni osoblivosti perebigu gostrih respiratornih Infektsiy u ditey rannogo viku, infikovanih tsitomegalovirusom. Sovremennaya pediatriya. 1 (57), 87-91.
Babik R.K. (2013). Kliniko-immunologicheskie osobennosti virusnyih kishechnyih infektsiy u detey. Extended abstract of Doctor’s thesis. Retrieved from http://medical-diss.com/medicina/kliniko-immunologicheskie-osobennosti-virusnyh-kishechnyh-infektsiy-u-detey
Selim Badur, Serdar Öztürk, Priya Pereira, et al. (2019) Systematic review of the rotavirus infection burden in the WHO-EMRO region, Human Vaccines & Immunotherapeutics, 15:11, 2754-2768, DOI: 10.1080/21645515.2019.1603984
Z.V. Eloeva, S. O. Matvienko, M. S. Dyachenko (2017). Diagnosticheskoe i prognosticheskoe znachenie vnutrikletochnyih vozbuditeley pri atipichnoy infektsionnoy patologii u detey. Problemi bezperervnoyi medichnoyi osviti ta nauki. 1, 21-26. Retrieved from http://www.irbis-nbuv.gov.ua/cgi-bin/irbis_nbuv/cgiirbis_64.exe?I21DBN=LINK&P21DBN=UJRN&Z21ID=&S21REF=10&S21CNR=20&S21STN=1&S21FMT=ASP_meta&C21COM=S&2_S21P03=FILA=&2_S21STR=Psmno_2017_1_6
S.G. Gorbunov, L.N. Mazankova, I.D. Maykova et al. (2018). Features of the immune response and the efficacy of immunotherapy for Rotavirus infection in children. Detskie Infektsii, 17 (3):38-46. doi.org/10.22627/2072-8107-2018-17-3-38-46
V.G. Maydannik, K.O. Smeyan-Gorbunova (2015). Osobennosti kletochnogo zvena immuniteta u detey, bolnyih mono-i mikst-variantami rotavirusnoy infektsii. Zdorove rebenka 2 (61), 15-18.
E.S. Olhovskiy, S. V. Kuznetsov (2016). Osoblivosti klinichnogo perebigu esherihiozu u ditey, Infikovanih virusom Epshteyna-Barr. Eksperementalna i klinichna meditsina. 4 (73), 73-77. Retrieved from http://nbuv.gov.ua/UJRN/eikm_2016_4_17
Long HM, Meckiff BJ, Taylor GS et al. (2019). The T-cell Response to Epstein-Barr Virus–New Tricks from an Old Dog. Front. Immunol. Vol.10:2193. doi: 10.3389/fimmu.2019.02193
Vigovska O.V. (2019) Gerpesvirusni infekciyi u ditej: klasifikaciya, klinichni formi, proyavi, socialno-medichni aspekti. Dityachij likar. 4(49):41-51. Retrieved from https://d-l.com.ua/ua/archive/2016/4%2849%29/pages-41-51/gerpesvirusni-infekciyi-u-ditey-klasifikaciya-klinichni-formi-proyavi-socialno-medichni-aspekti
Usachova, O. V., Paholchuk, T. M., Silina, E. A., et al (2013). Osoblivosti perebigu rotavirusnoyi Infektsiyi u ditey rannogo viku z tsitomegalieyu ta pidhodi do patogenetichnoyi terapiyi. Sovremennaya pediatriya, (1), 134-138.
Views:
187
Downloads:
164
Copyright (c) 2021 Marharyta Yu. Sliepchenko
This work is licensed under a Creative Commons Attribution 4.0 International License.
All articles are published in open-access and licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0). Hence, authors retain copyright to the content of the articles.
CC BY 4.0 License allows content to be copied, adapted, displayed, distributed, re-published or otherwise re-used for any purpose including for adaptation and commercial use provided the content is attributed.
