ALTERATIONS OF LOCAL BLOOD FLOW IN THE PENUMBRA ZONE OF LOCAL CEREBRAL INFARCTION

Tchlikadze N.; Arabuli M.; Nikuradze N.; Solomonia R.; Mitagvaria N.

doi:10.31435/rsglobal_ws/31052019/6513

Tchlikadze N. Ilya State University, Tbilisi, Georgia
Arabuli M. Tbilisi State Medical University, Tbilisi, Georgia
Nikuradze N. Tbilisi State Medical University Tbilisi, Georgia
Solomonia R. Ilya State University. Ivane Beritashvili Center for Experimental Biomedicine Tbilisi, Georgia
Mitagvaria N. Ivane Beritashvili Center for Experimental Biomedicine Tbilisi, Georgia

DOI: https://doi.org/10.31435/rsglobal_ws/31052019/6513

Keywords: Photochemical Stroke, Penumbra, Blood Flow, Cerebral Cortex, Rats

Abstract

The main objective of this study was to reveal the circulatory changes in the Penumbra zone of stroke, which was induced by the photochemical method in the cerebral cortex of the rats. It has been revealed that the maximum reduction in blood supply in the penumbra zone during permanent ischemia is achieved 24 hours after the completion of the process of inducing thrombosis of vessels. Therapeutic intervention to save the cells of the Penumbra zone, which are in the initial stages of apoptosis, it is advisable to carry out in the first 12 hours after the onset of stroke.

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