MARKERS OF CONNECTIVE TISSUE METABOLISM IN PATIENTS WITH DIABETIC ARTHROPATHY
Abstract
The aim of study was to investigate markers of connective tissue metabolism (COMP level) and indicators that reflect the synthetic and catabolic phases of the metabolism of the main components of connective tissue - collagen and glycosaminoglycans in patients with diabetic arthropathy.
The study involved 87 patients with diabetes. Patients were examined using a visual analogue scale of the Leken index and WOMAK. Cartilage oligomeric matrix Protein (COMP) was determined using enzyme immunoassay.
Results. The presence of diabetic arthropathy was detected in 78% of patients with type 1 diabetes and in 80% of patients with type 2 diabetes. In the vast majority of patients, the joints of the upper extremities were involved in the pathological process. A direct correlation was established between the presence of arthropathy and the COMP level (r = 0.76, p = 0.001), the Leken index (r = 0.76, p = 0.001), YOUR scale (r = 0.88 , p = 0.001) and WOMAK (R = 0.88, p = 0.001). Patients with type 1 diabetes with joint damage are characterized by a compensatory increase in the synthesis of subchondral bone in response to increased collagen breakdown. For patients with type 1 diabetes with joint damage is characterized by a compensatory increase in subchondral bone synthesis in response to increased collagen breakdown.
Conclusions: The results suggest that arthropathy in patients with type 1 and type 2 diabetes is characterized by an increase in the cartilage degradation marker in direct proportion to the severity and number of affected joints.
References
Haugen IK, Magnusson K, Turkiewicz A, Englund M. (2017) The Prevalence, Incidence, and Progression of Hand Osteoarthritis in Relation to Body Mass Index, Smoking, and Alcohol Consumption. J Rheumatol., 44(9), 1402-1409. doi: 10.3899/jrheum.170026
Louati, K., Vidal, C., Berenbaum, F., Sellam, J. (2015). Association between diabetes mellitus and osteoarthritis: systematic literature review and meta-analysis. R.M.D, 1, e000077. doi: 10.1136/rmdopen-2015- 000077
Rehling T., Bjørkman A., Dam, Andersen M., Ekholm O., Molsted S. (2019) Diabetes is associated with musculoskeletal pain, ostheoarthritis,, osteoporosis and rheumatoid arthritis, 2019 Article ID 6324348 https://doi.org/10.1155/2019/6324348
Berenbaum F. (2012). Diabetes-induced osteoarthritis: from a new paradigm to a new phenotype. Postgrad. Med. J, 88, 240-242. doi: 10.1136/pgmj.2010.146399rep.
King K.B., 2015 King, K. B., & Rosenthal, A. K. (2015). The adverse effects of diabetes on osteoarthritis: update on clinical evidence and molecular mechanisms. Osteoarthritis and Cartilage, 23(6), 841–850. doi: 10.1016/j.joca.2015.03.031
Watt, F.E. (2018). Osteoarthritis biomarkers: Year in review. Osteoarthr. Cartil, 26, 312–318. doi: 10.1016/j.joca.2017.10.016.
Starodubceva, A.I., Vasileva, L.V. (2016). Sravnitelnyi analiz urovnya oligomernogo matriksnogo proteina hrashcha v syvorotke krovi pacientov s zabolevaniyami kostno-myshechnoy sistemy [Comparative analysis of the level of oligomeric matrix cartilage protein in the serum of patients with diseases of the musculoskeletal system]. Clinical laboratory diagnostics, 6 (2), 83-86. doi: 10.18821/0869-2084-2016-61-2-83-86 [in Russian]
Firner, S., Zaucke, F., Heilig, J., de Marées, M., Willwacher, S., Brüggemann, G.P., Niehoff, A. (2020). Impact of knee joint loading on fragmentation of serum cartilage oligomeric matrix protein. J. Orthop Res, 1, 1-9. doi: 10.1002/jor.24586.
Hao, H.Q., Zhang, J.F., He, Q.Q., Wang, Z. (2019). Cartilage oligomeric matrix protein, C-terminal cross-linking telopeptide of type II collagen, and matrix metalloproteinase-3 as biomarkers for knee and hip osteoarthritis (OA) diagnosis: a systematic review and meta-analysis, Osteoarthritis Cartilage, 27(5), 726-736. doi: 10.1016/j.joca.2018.10.009.
Hoch, J.M., Mattacola, C.G., Medina McKeon, J.M., Howard, J.S., Lattermann, C. (2011). Serum cartilage oligomeric matrix protein (sCOMP) is elevated in patients with knee osteoarthritis: a systematic review and meta-analysis. Osteoarthritis and Cartilage, 19(12), 1396–1404. doi: 10.1016/j.joca.2011.09.005
Hosnijeh, F.S., Siebuhr, A.S., Uitterlinden, A.G., Oei, E.H.G., Hofman, A., Karsdal, M.A., Bierma-Zeinstra, S.M., Bay-Jensen, A.C., van Meurs, J.B.J. (2016). Association between biomarkers of tissue inflammation and progression of osteoarthritis: Evidence from the Rotterdam study cohort. Arthritis Res. Ther, 18, 81. doi: 10.1186/s13075-016-0976-3.
Posey, K.L., Hecht, J.T. (2008). The role of cartilage oligomeric matrix protein (COMP) in skeletal disease. Curr. Drug Targets, l(9), 869–877 doi: 10.2174/138945008785909293.
Acharya C., Yik J.H.N., Kishore A., Dinh V.V., Di Cesare P.E., Haudenschild D.R. (2014). Cartilage oligomeric matrix protein and its binding partners in the cartilage extracellular matrix: Interaction, regulation and role in chondrogenesis. Matrix Biol, 37, 102–111. doi: 10.1016/j.matbio.2014.06.001.
Posey, K.L., Coustry, F., Hecht, J.T. (2018). Cartilage oligomeric matrix protein: COMPopathies and beyond. Matrix Biol, 71–72, 161–173. doi: 10.1016/j.matbio.2018.02.023.
Scully S. P., Lee J. W., Ghert P. M. A., Qi W. The role of the extracellular matrix in chondrocyte regulation. Clin. Orthop. Relat. Res. 2001;391:72–89.
Sabah Ali, Zainab A., Sahar H., Abdul-Kareem, Heba F. Hassan, Rasha M., Shaker Rasha A. Azeez Estimation of Serum Matrix Metalloproteinases-1 Levels in Iraqi Female Patients with Osteoarthritis. Int. J. Med. Res. Health Sci. 2018;7(5): 18-22
Won Gyung Gho, Yuri Choi, Kwang-Ho Park, and Jong-Ki Huh. Expression of collagenases (matrix metalloproteinase-1, 8, 13) and tissue inhibitor of metalloproteinase-1 of retrodiscal tissue in temporomandibular joint disorder patients J. Korean Assoc. Oral Maxillofac Surg 2018. Jun; 44(3):120-126. English doi: 10.5125/jkaoms.2018. 44.3.120
Jarallah, K., Shehab, D., Abdella, N. Al Mohamedy, H., Abraham, M. (2016). Knee Osteoarthritis in Type 2 Diabetes Mellitus Does Insulin Therapy Retard Osteophyte: Formation? Med. Princ. Pract, 25, 12-17 https://doi.org/10.1159/000441418
Sellam, J., Berenbaum, F. (2013). Is osteoarthritis a metabolic disease? Joint Bone Spine, 80, 568-573. doi: 0.1016/j.jbspin.2013.09.007.
Robertson, F., Geddes, J., Ridley, D., McLeod, G., Cheng, K. (2012). Patients with type 2 diabetes mellitus have a worse functional outcome post knee arthroplasty: a matched cohort study. Knee, 19, 286-289. doi: 10.1016/j.knee.2011.06.001.
Frey, N., Hugle, T., Jick, S.S., Meier, C.R., Spoendlin, J. (2016). Type II diabetes mellitus and incident osteoarthritis of the hand: apopulation-based case-control analysis. Osteoarthr Cartil, 24(9), 1535–40. doi: 10.1016/j.joca.2016.04.005
Yacishin, R.Ya., Suhorembska M.Ya. (2015). Rol biomarkeriv poshkodzhennya suglobovogo hrashcha v diagnostuci ta likuvanni hvorykh na osteoartroz [ The role of biomarkers of articular cartilage damage in the diagnosis and evaluation of osteoarthritis patients]. Ukrainian Rheumatology Journal, 2(60), 37-41 [in Ukrain]
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