IMMUNOPATHOGENETIC FEATURES OF MONONUCLEOSIS IN CHILDREN WITH VARIOUS MICROBIAL FLORA OF THE RHINOPHARYNX
Abstract
One of the most common childhood diseases is infectious mononucleosis (IM), which Epstein-Barr virus (EBV) is a causative factor. According to WHO statistics, more than 5 million children die every year from the indicated infectious pathology and its consequences in the world. Streptococcus pyogenes, Streptococcus pneumoniae and other Streptococcus, Enterococcus, Lactobacillus Actinomices, Neisseria, Actinomyces, Clostridium, Pseudomonas, Staphylococus epidermidis, Staphylococus aureus are most often detected in the oral cavity and nasopharynx. In the available literature there are practically no works that would consider the effect of microbial flora of the mucous membrane of the rhinopharynx on the formation of the immune response of children with IM.
References
Abbott RJ, Quinn LL, Leese AM, Scholes HM, Pachnio A, Rickinson AB. CD8+ T cell responses to lytic EBV infection: late antigen specificities as subdominant components of the total response. J Immunol.2013;191:5398–5409. doi: 10.4049/jimmunol.1301629.
Ali AS, Al-Shraim M, Al-Hakami AM, Jones IM. Epstein- Barr Virus: Clinical and Epidemiological Revisits and Genetic Basis of Oncogenesis. Open Virol J. 2015 Nov 3. 9:7-28. [Medline].
Bobruk S. V. The degree of indicators level violation of local immunity in children with infectious mononucleosis. Journal of Education, Health and Sport 2017. №3. С. 576-585
Cunha BA, Petelin A, George S. Fever of unknown origin (FUO) in an elderly adult due to Epstein-Barr virus (EBV) presenting as "typhoidal mononucleosis," mimicking a lymphoma.Heart Lung. 2013 Jan-Feb. 42(1):79-81. [Medline].
Engelmann I, Nasser H, Belmiloudi S, et al. Clinically severe Epstein-Barr virus encephalitis with mild cerebrospinal fluid abnormalities in an immunocompetent adolescent: a case report. Diagn Microbiol Infect Dis. 2013 Jun. 76(2):232-4. [Medline].
Rickinson AB, Fox CP. Epstein-barr virus and infectious mononucleosis: what students can teach us. J Infect Dis. 2013 Jan. 207(1):6-8. [Medline].
Rostgaard K, Wohlfahrt J, Hjalgrim H. A genetic basis for infectious mononucleosis: evidence from a family study of hospitalized cases in Denmark. Clin Infect Dis. 2014 Jun. 58(12):1684-9. [Medline].
Tso K.K., Yip K.Y., Mak C.K., Chung G.T., Lee S.D., Cheung S.T., To K.F., Lo K.W. Complete genomic sequence of Epstein-Barr virus in nasopharyngeal carcinoma cell line C666-1. Infect. Agent. Cancer.2013;8(1):29. doi: 10.1186/1750-9378-8-29.
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