ACTOPROTECTOR ACTIVITY OF 4-R-(IDENEAMINO)- 5-R-4Н-1,2,4-TRIAZOLE-3-THIOLS

  • Hlazunova T. V. Ukraine, Zaporizhzhia, Zaporizhzhia State Medical University
  • Panasenko O. I. prof., Ukraine, Zaporizhzhia, Zaporizhzhia State Medical University
  • Knysh Ye. H. prof., Ukraine, Zaporizhzhia, Zaporizhzhia State Medical University
Keywords: actoprotector activity, 1,2,4-triazole derivatives, structure-activity

Abstract

In this study, actoprotector activity of 1,2,4-triazole derivatives is described. The biological activity of synthetic 4-R-(ideneamino)-5-R-4Н-1,2,4-triazole-3- thiols was analyzed. The forced swim test with a weight load of 10% of the test animal’s body weight was applied. According to the obtained results, compounds that contained NH4+ and CuSO4 substituents were among the most active, potency of which was close to that of the reference drug Riboxin. Introduction of propylamine, isopropylamine and piperazine groups into the molecule decreases the actoprotector activity. Compounds containing monoethanolamine, diethylamine, ethylamine, and magnesium sulfate moieties almost did not exhibit actoprotector activity.

References

Ganapolskiy, V. P. (2008). Razrabotka i izucheniye novykh meteo-adaptagenov [Research and development of new meteo-adaptogens]. Dissertation Abstract, HAC RF 14.00.25. S.M. Kirov Military Medical Academy, St.-Petersburg, Russian Federation.

Mashkovskiy, M. D. (2002). Lekarstvennyye sredstva [Pharmaceutical products] (Vols. 1-2). S. B. Divov (Ed.). Moscow, Russian Federation: Novaya Volna.

Pruhlo, Ye. S., Safonov, A. A., Panasenko, O. I., & Knysh, Ye. H. (2013). Aktoprotektorna aktyvnist pokhidnykh N-R-3-alkiltio-5-R1-4H-1,2,4-triazol-4-aminiv [Actoprotector activity of N-R-3-alkylthio-5-R1-4H-1,2,4-triazole-4- amine derivatives]. Current issues in pharmacy and medicine: Science and practice, 3(13), 99-101.

Safonov, A. A. (2016). Aktoprotektorna aktyvnist 4-((R-iden)amino)-5-(tiofen-2-ilmetyl)-4H-1,2,4-tryazol- 3-tioliv [Actoprotector activity of 4-((R-idene)amino)-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazol-3-thiol derivatives]. Ukrainian Biopharmaceutical Journal, 2(43), 32-34.

Kravchenko, T. V. (2018). The search for new 4-amino-5-methyl-4H-1,2,4-triasole-3-thion derivatives with diuretic activity. Zaporozhye Medical Journal, 20(3), 421-424.

Bihdan, O. A., Parchenko, V. V., Panasenko, O. I., & Knysh, Ye. H. (2016). Farmakolohichni aspekty zastosuvannia furanpokhidnykh 1,2,4-triazol-3-tioliv [Pharmacological aspects of application of 1,2,4-triazole-3- thiol furan derivatives]. Current issues in pharmacy and medicine: Science and practice, 3(22), 98-102.

Pruhlo, Ye. S., Hotsulia, A. S., Panasenko, O. I., & Knysh, Ye. H. (2013). Anksiolitychna aktyvnist solei 2-((5- ((1,3-dymetyl-2,6-diokso-2,3-dyhidro-1N-puryn-7(6N)-il)metyl-4-R-4H-1,2,4-triazol-3-il)tio)atsetatnykh kyslot [Anxiolytic activity of 2-((5-((1,3-dimethyl-2,6-dioxo-2,3-dihydro-1N-purin-7(6N)-yl)methyl-4-R-4H-1,2,4- triazol-3-yl)thio)acetate salts]. Pharmacology and Drug Toxicology, 3(34), 23-27.

Bobkov, Yu. G., Vinogradov, V. I., Katkov, V. F., Losev, S. S., & Smirnov, A. V. (1984). Farmakologicheskaya korrektsiya utomleniya [Pharmacological correction of fatigue]. Moscow, Russian Federation: Meditsina.

Knysh, Ye. H. (1987). Sintez, fiziko-khimicheskiye i biologicheskiye svoystva N- i S-zameshchennykh 1,2,4- triazola [Synthesis, physical, chemical, and biological properties of N- and S-substituted 1,2,4-triazoles] (Doctoral dissertation). Zaporizhzhia State Medical University, Zaporizhzhia, Ukraine.

Stefanov, O. B. (Ed.). (2001). Doklinichni doslidzhennia likarskykh zasobiv: Metodychni rekomendatsii [Pre-clinical research of pharmaceuticals: Methodological recommendations]. Kyiv, Ukraine: Avitsena.

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Published
2019-11-30
Citations
How to Cite
Hlazunova T. V., Panasenko O. I., & Knysh Ye. H. (2019). ACTOPROTECTOR ACTIVITY OF 4-R-(IDENEAMINO)- 5-R-4Н-1,2,4-TRIAZOLE-3-THIOLS. Science Review, (9(26), 23-26. https://doi.org/10.31435/rsglobal_sr/30112019/6817
Section
Chemistry