РАСПРОСТРАНЕННОСТЬ КИШЕЧНЫХ ПАРАЗИТОЗОВ У ВИЧ-ПОЗИТИВНЫХ ПАЦИЕНТОВ
Abstract
A cross-sectional study among people living with HIV (PLHIV), who are naive and who are on antiretroviral treatment (ART) was conducted in Kyiv, Ukraine from January 2017 to June 2019. In 200 samples of feces from PLHIV were detection intestinal parasites and helminthes. Also in all patients was measure of CD4 T cells by flow cytometry technique and the viral load of HIV (HIV VL) by reverse transcription and polymerase chain reaction, sensitivity of test – 40 copies HIV RNA / ml. The study shows high prevalence of intestinal parasitic in population of PLHIV – 30,0%. The most prevalent parasites were Cryptosporidium (10,5%), Ascaris lumbricoides (1,5%), G. lamblia (0,5%). Opportunistic protozoans (B. Hominis) were found in 15.5% of PLHIV. Among PLHIV with intestinal parasites severe immunosuppression (< 200 CD4 cells/ml) were more common (66.7%) than among PLHIV without intestinal parasites (45.7%); patients with undetectable HIV VL (35.0%), patients receiving ART for more than 6 months (28.3%) were less common (55.7% and 54.3% respectively). In all cases P value was less than 0.05. Our data show that detection even opportunistic intestinal protozoans in PLHIV can be used as a marker of immune suppression and HIV replication activity, and confirms the importance of parasitological surveillance in this group of patients.
References
Framm S.R. Soave R. Agents of diarrhea. Med Clin North Am. 1997; 81:427–447.
Taye B., Desta K., Ejigu S., Dori G.U. The magnitude and risk factors of intestinal parasitic infection in relation to Human Immunodeficiency Virus infection and immune status, at ALERT Hospital, Addis Ababa, Ethiopia. Parasitol Int. 2014; 63(3): 550-556.
Roka M., Goñi P., Rubio E., Clavel A. Intestinal parasites in HIV-seropositive patients in the Continental Region of Equatorial Guinea: its relation with socio-demographic, health and immune systems factors / Trans R. Soc. Trop. Med. Hyg. 2013; 107(8): 502-510.
Akinbo F.O., Okaka C.E., Omoregie R. Prevalence of intestinal parasites in relation to CD4 counts and anaemia among HIV-infected patients in Benin City, Edo State, Nigeria Tanzan. J. Health Res. 2011; 13(1): 8-13.
Shimelis T., Tassachew Ya., Lambiyo T. Cryptosporidium and other intestinal parasitic infections among HIV patients in southern Ethiopia: significance of improved HIV-related care. Parasit Vectors. 2016;.9:.270-277.
Wang ZD, Liu Q, Liu HH, Li S, Zhang L, Zhao YK, Zhu XQ. Prevalence of Cryptosporidium, microsporidia and Isospora infection in HIV-infected people: a global systematic review and meta-analysis. Parasit Vectors. 2018 Jan 9;11(1):28.
Taye B., Desta K., Ejigu S., Dori G.U. The magnitude and risk factors of intestinal parasitic infection in relation to Human Immunodeficiency Virus infection and immune status, at ALERT Hospital, Addis Ababa, Ethiopia // Parasitol Int. 2014; 63(3):550-600.
Missaye A, Dagnew M, Alemu A, Alemu A. Prevalence of intestinal parasites and associated risk factors among HIV/AIDS patients with pre-ART and on-ART attending dessie hospital ART clinic, Northeast Ethiopia. AIDS Res Ther. 2013;10(1): 7-15.
Teklemariam Z., Abate D., Mitiku Н., Dessie Ya. Prevalence of Intestinal Parasitic Infection among HIV Positive Persons Who Are Naive and on Antiretroviral Treatment in Hiwot Fana Specialized University Hospital, Eastern Ethiopia // ISRN AIDS. 2013. http://dx.doi.org/10.1155/2013/324329
Masoumi-As H, Khanaliha K, Bokharaei-Salim F, Esteghamati A, Kalantari S, Hosseinyrad M. Enteric Opportunistic Infection and the Impact of Antiretroviral Therapy among HIV/AIDS Patients from Tehran, Iran. J Public Health. 2019 Apr;48(4):730-739.
Nsagha D., Njunda A., Assob N. Intestinal parasitic infections in relation to CD4+ Tcell counts and diarrhea in HIV/AIDS patients with or without antiretroviral therapy in Cameroon. BMC Infectious Diseases. 2016; 16(9): 1-10.
Склад для обробки проб досліджуваного матеріалу при проведенні досліджень біологічних матеріалів: патент, Україна No 114976; від 28.08.2017 р. заявл.17.03.2016; опубл.28.08.2017. Бюл.No16.
WHO. Interim WHO clinical staging of HVI/AIDS and HIV/AIDS case definitions for surveillance: African Region. World Health Organization; 2005.
Silva C.V., Ferreira M.S., Borges A.S., Costa-Cruz J.M. Intestinal parasitic infections in HIV/AIDS patients: experience at a teaching hospital in central Brazil // Scand J Infect Dis. 2005; 37(3): 211-215.
Assefa S, Erko B, Medhin G, Assefa Z, Shimelis T. Intestinal parasitic infections in relation to HIV/AIDS status, diarrhea and CD4 T-cell count. BMC Infect Dis. 2009;9:155.
Getaneh A, Medhin G, Shimelis T. Cryptosporidium and Strongyloides stercoralis infections among people with and without HIV infection and efficiency of diagnostic methods for Strongyloides in Yirgalem Hospital, southern Ethiopia. BMC Res Notes. 2010;3:90.
Gebrewahid T, Gebrekirstos G, Teweldemedhin M, Gebreyesus H, Awala A, Tadla K. Intestinal parasitosis in relation to CD4 count and anemia among ART initiated patients in St. Mary Aksum general hospital, Tigray, Ethiopia. BMC Infect Dis. 2019 Apr 27;19(1):350.
Zorbozan O, Quliyeva G, Tunalı V, Özbilgin A, Turgay N, Gökengin AD. Intestinal Protozoa in Hiv-Infected Patients: A Retrospective Analysis. Turkiye Parazitol Derg. 2018 Sep;42(3):187-190.
Шагінян В.Р., Данько О.П., Сопіль Г.В., Антоняк С.М., Дяченко О.П. Інвазованість кишковими паразитами ВІЛ-позитивних осіб. Профілактична медицина. 2018; 1(30):91-97.
Барлетт Д., Галлант Д. Фам П. Клинические аспекты ВИЧ-инфекции. 2009-2010. М.: Р.Валент, 2010. 490с.
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