QUALITY ASSESSMENT, SPECIFICS OF ORGANIZATION AND PROVISION OF MEDICAL CARE TO STROKE PATIENTS ACCORDING TO THE HOSPITAL REGISTER OF VRCPH NAMED AFTER ACADEMICIAN O. I. YUSHCHENKO OF VRC AND VCCH EMS FOR THE PERIOD 2017-2019

Currently, one of the most important tasks is to improve the quality of medical services, which becomes possible in retrospective register analysis of medical and organizational technologies, which include algorithms for providing medical care, continuity of medical institutions, protocols for diagnosis and treatment of diseases. The stroke register was created on the basis of medical documentation of hospitals, which are the most typical for the Podillia region of Ukraine. Statistical processing of the results was performed using the licensed statistical package "Statistica 5.5" using parametric evaluation methods. Significant differences in the organization of the medicaldiagnostic process and approaches to treatment have been established between the two medical institutions of Vinnytsia in the dynamics of time. There was a positive trend in the time of stroke treatment, the use of drugs with a high degree of evidence and the coverage of patients with specialized, multidisciplinary care in a stroke. KEYWORDS

In Ukraine, there is a question of establishing stroke centers and departments in both large cities and regional centers to provide highly qualified, specialized care to patients with ACA with the involvement of multidisciplinary teams consisting of specially trained medical staff [3]. Early discharge with subsequent accompaniment (supervision) of the patient in the context of multidisciplinary team care shows good results in patients, significantly reduces the time spent in the stroke unit and in the hospital in general [4,5]. The establishment of these units in our country is the most effective strategy for providing care to patients with ACA. They are effective and cost-effective for the future, as they are more effective in reducing mortality and disability [6].
Treatment of the acute period of stroke includes basic therapy and prevention of somatic complications. Given the high mortality rate during the first month and the next 12 months after stroke, it is necessary to begin prevention of recurrent stroke in parallel with the provision of emergency specialized medical care to patients with ACA [7,8]. The main principles of secondary prevention are the correction of risk factors and drug therapy. The strategy of individualized secondary stroke prevention is developed in the first day of the patient's stay in the hospital. It includes the use of statins, antihypertensive, antithrombotic drugs, correction of carbohydrate metabolism disorders, if necessarysurgical treatments [9,10].
The purpose of the researchto study and compare the organization and level of medical care for stroke patients according to the registers of hospitals in Vinnytsia during 2017-2019.
Material and methods of research. Data on stroke cases were obtained on the basis of medical documentation of medical institutions that are most typical for the Podillia region of Ukraine (Vinnytsia, most of Khmelnytsky, part of Ternopil, as well as small adjacent areas of Zhytomyr and Cherkasy regions). Data collection and processing was performed by a certified neurologist.
We conducted a retrospective analysis of the results of medical histories of patients hospitalized for emergency appointments to the stroke unit of the Municipal Non-Profit Enterprise «Vinnytsia Regional Clinical Psychoneurological Hospital named after Academician O. I. Yushchenko of Vinnytsia Regional Council» (VRCPNH) or Vinnytsia City Clinical Hospital of Emergency Medical Services (VCCHEMS) for the period 2017-2019 with a diagnosis of ACA (Table  1). After inpatient treatment, a RES-Q report form was completed on a case-by-case basis -a special report form in an international program developed by the European Stroke Society (ESO) ESO-EAST initiative. Since 2017, the hospitals we surveyed have been participating in this program.  Hospitals  VRCPNH  VCCHEMS  men  women  men  women   General   2017  307  209  351  335  2018  312  187  310  306  10 months of 2019  287  175  182  163   Ischemic  stroke   2017  269  184  308  296  2018  267  166  276  282  10 months of 2019  248  152  162  153   Hemorrhagic  stroke   2017  37  25  42  39  2018  45  21  34  24  10 months of 2019  39  23  20  10 Data on the treatment were recorded: the use of certain groups of drugs (antihypertensive, antithrombolytic, statins), recanalization intervention, hematoma surgery. The quality indicators of the organization of the medical-diagnostic process were also considered: door-to-needle time, duration of treatment, hospitalization to the stroke unit.
Statistical processing of the survey results was performed using the statistical package "Statistica 5.5" (licensed № AXXR910A374605FA) using parametric evaluation methods.
Results and discussion. When comparing the percentage of patients who were hospitalized for stroke, VRCPNH found a significantly (p<0.05-0.001) higher value in patients with ischemic stroke (2017 -76.9 % in men in general and 74.7 % with ischemic stroke; 70.3 % in women in general and 69.0 % with ischemic stroke; in 2018 -97. 8  In VRCPNH, the percentage of patients who were hospitalized in the stroke unit in the dynamics of 2017-2019 significantly (p<0.05-0.001) increased (2017 -76.9 % in men in general, 74.7 % with ischemic stroke and 91.9 % with hemorrhagic stroke; 70.3 % in women in general, 69.0 % with ischemic stroke and 80.0 % with hemorrhagic stroke; in 2018 -97.8 % in men in general, 97.4 % with ischemic stroke and 100 % with hemorrhagic stroke; 98.9 % in women in general, 98.8 % with ischemic stroke and 100 % with hemorrhagic stroke; in 2019 -97.2 % for men in general and 97.2 % with ischemic stroke; 98.3 % for women in general and 98.7 % with ischemic stroke).
VCCHEMS also significantly increased over time (p<0.01-0.001) the percentage of patients hospitalized for stroke (2017 -57.0 % in men in general, 52.9 % in ischemic stroke; 58.5 % in women in general, 56.4 % in ischemic stroke; in 2018 -74.5% in men in general, 72.5% with ischemic stroke; 76.5 % in women in general, 76.6 % with ischemic stroke; in 2019 -85.7 % in men in general and 85.2 % with ischemic stroke; 87.7 % in women in general and 86.9 % with ischemic stroke).
There were no significant differences in the intake of vitamin K antagonist by patients between medical institutions and in the dynamics of time.
When comparing the percentage of patients receiving antiplatelet agents, VRCPNH in 2017-2019 found a significantly (p<0.05-0.001) lower value (2017 -68.7 % in men in general, 77.3 % with ischemic stroke; 66.5 % in women in general, 75.0 % with ischemic stroke; in 2018 -69.9 % in men in general, 81.3 % with ischemic stroke; 66.8 % in women in general, 74.7 % with ischemic stroke; in 2019 -61.7 % in men in general and 71.4 % in ischemic stroke; 53.7 % in women in general and 60.5 % in ischemic stroke) compared to VCCHEMS (2017 -78.6 % in men in general, 85.7 % in ischemic stroke; 77.0 % in women in general, 84.5 % with ischemic stroke; 2018 -83.5 % in men in general, 92.8 % with ischemic stroke; 83.7 % in women in general, 89.7 % with ischemic stroke; in 2019 -80.2 % in men in general and 88.9 % with ischemic stroke; 82.8 % in women in general and 86.9 % in ischemic stroke).
In VRCPNH, the percentage of patients receiving antiplatelet agents decreased significantly (p<0.05-0.01) over time (2017 -68.7 % in men in general, 77.3 % in ischemic stroke; 66.5 % in women in general, 75.0 % with ischemic stroke; in 2018 -69.9 % in men in general, 81.3 % with ischemic stroke; 66.8 % in women in general, 74.7 % with ischemic stroke; in 2019 -61.7 % in men in general and 71.4 % with ischemic stroke; 53.7 % in women in general and 60.5 % with ischemic stroke).
In VCCHEMS, the percentage of patients receiving antiplatelet agents increased significantly over time (p<0.05-0.01) (2017 -78.6 % in men in general, 85.7 % with ischemic stroke; 77.0 % in women in general; in 2018 -83.5 % in men in general, 92.8 % with ischemic stroke; 83.7% in women in general).
When comparing the percentage of patients receiving dabigatran, VRCPNH in 2017-2019 found a significantly (p<0.05-0.001) higher value (2017 -8.8 % in men in general, 10.0 % with ischemic stroke; 5.7 % in women in general, 6.5 % with ischemic stroke; in 2018 -7.7 % in men in general, 9.0 % with ischemic stroke; 11.8 % in women in general, 13.3 % with ischemic stroke; in 2019 -9.4 % in men in general and 10.9 % in ischemic stroke; 16.6 % in women in general and 19.1 % with ischemic stroke) compared to VCCHEMS (2017 -0.9 % in men in general, 1.0 % with ischemic stroke' 0.6 % in women in general, 0.7 % with ischemic stroke' 2018 -0.3 % in men in general, 0.4 % with ischemic stroke' 0.7 % in women in general, 0.7 % with ischemic stroke' in 2019 -2.7 % in men in general and 3.1 % with ischemic stroke' 3.7 % in women in general and 3.9% in ischemic stroke).
In VRCPNH, the percentage of patients receiving dabigatran increased significantly over time (p<0.05-0.01) (2017 -8.8 % in men in general, 10.0 % in ischemic stroke; 5.7 % in women in general, 6.5 % with ischemic stroke; in 2018 -7.7 % in men in general, 9.0 % with ischemic stroke; 11.8 % in women in general, 13.3 % with ischemic stroke; in 2019 -9.4 % in men in general and 10.9 % with ischemic stroke; 16.6 % in women in general and 19.1 % with ischemic stroke).
In VCCHEMS, the percentage of patients receiving dabigatran increased significantly (p<0.05-0.01) over time (2018 -0.3 % in men in general, 0.4 % in ischemic stroke; 0.7 % in women in general and 0.7 % in ischemic stroke; 2019 -2.7 % for men in general, 3.1 % with ischemic stroke; 3.7 % for women in general and 3.9 % with ischemic stroke).
When comparing the percentage of patients receiving other antithrombotic drugs, VRCPNH in 2019 found a significantly higher value (p<0.01-0.001) (2019 -4.5 % in men in general, 5.2 % with ischemic stroke; 6.3 % in women in general, 7.2 % with ischemic stroke) compared to VCCHEMS (2019 -0% for men in general, 0 % with ischemic stroke; 0 % for women in general, 0 % with ischemic stroke).
In It is impossible to compare the average door-to-needle time between the two institutions and in the dynamics of VCCHEMS due to the lack of data in the medical histories of the latter (no recanalization procedure was performed).
In There were no significant differences in the performance of surgical treatment of hematoma between medical institutions and in the dynamics of time.
The implementation of the program to combat ischemic stroke, which introduced the method of thrombolytic reperfusion therapy, has allowed in recent years to achieve significant success in the treatment and rehabilitation of patients [11,12,13]. The method is based on the concept of ischemic penumbra, which prevents or minimizes the development of irreversible damage to the substance of the brain [14,15]. However, the time parameter ("door-to-needle time") can be a problematic aspect of the success and efficiency of this procedure. This indicator, along with the duration of treatment, the fact of hospitalization for stroke, in the analysis of the hospital register allows us to judge the organization of care for stroke patients and its impact on the consequences of the disease.
Conclusions. Analysis of the dynamics of treatment duration for the period 2017-2019 shows its decrease in VCCHEMS and increase in VRCPNH. The rate of hospitalization in the stroke unit for both hospitals in 2019 compared to previous years has increased. A study of the duration of door-toneedle time in VRCPNH shows its increase in 2019 compared to 2017 and 2018. There is an increase in the percentage of patients prescribed antithrombolytic drugs with a high degree of evidence and safety (rivaroxaban and dabigatran). The percentage of patients taking antihypertensive drugs and statins has increased, which may indicate both adherence to uniform treatment protocols and the fact that the percentage of patients with hypercholesterolemia and hypertension is increasing over time.